个人简介

Ph.D. - University of Washington, Seattle, WA Postdoctoral Fellow & Research Scientist - Institute for Systems Biology, Seattle, WA

研究领域

Proteomics and Bioanalytical Chemistry

Our research is interdisciplinary. We develop and utilize liquid-chromatography and mass-spectrometry based proteomics tools to study cell-surface N-glycoproteins which play important roles in stem-cell development. Through various model systems, we want to understand how extra-cellular microenvironment influences stem-cell function and behavior through these proteins and their N-glycosylation pattern. Lab members are formed from a group of pasionated and highly motivated graduate and undergraduate students coming from different disciplines including chemistry, biochemistry, molecular and cellular biology, engineering and computer science.

近期论文

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Method Comparison for Analyzing Wound Healing RatesPrabhpreet K. Dhillon, Xinyin Li, Jurgen T. Sanes, Oluwafemi S. Akintola, Bingyun Sun*Biochemistry and Cell Biology, 2016, 10.1139/bcb-2016-0163 Membrane Gene Ontology Bias in Sequencing and Microarray Obtained by Housekeeping-Gene AnalysisZhang, Y.; Akintola,S. O.; Liu, J. K.; and Sun, B.*GENE, 2016, 575 (2 Pt2), 559-566 Detection Bias in Microarray and Sequencing Transcriptomic Analysis Identified by Housekeeping GenesZhang, Y.; Akintola,S. O.; Liu, J. K.; and Sun, B.*Data In Brief, 2015, 6, 121-123 Do Housekeeping Genes Exist?Zhang, Y.; Li, D.; and Sun, B.*PLOS ONE, 2015, 10(5), e0123691. doi: 10.1371/journal.pone.0123691 Proteomics and Glycoproteomics of Pluripotent Stem-Cell Surface ProteinsSun, B.*Proteomics, 2015, 15(5-6), 1152-1163 Sodium Dodecyl Sulfate Polyacrylamide Gel Eletrophoresis for Direct Quantitation of Protein AdsorptionLee, G.; Wu, K.; Nguyen, T. and Sun, B.*Analytical Biochemistry, 2014, 465C, 102-104 Protein-Centric N-GlycoProteomics Analysis of Membrane and Plasma Membrane ProteinsSun, B.* and Hood, L.Journal of Proteome Research, 2014, 13(6), 2705-2714. Glycopeptide Capture for Cell Surface ProteomicsLee, G. and Sun, B.*JoVE, 2014, 87, doi: 10.3791/51349. Glycocapture-Assisted Global Quantitative Proteomics (gagQP) Reveals Multiorgan Responses in Blood ToxicoproteomeSun, B.*; Ranish, J.A.; Utleg, A.G.; Hu, Z.; Keller, A.; Qin, S., Lorang, C.; Gray, L.; Brightman, A.; Lee, D.; Alexander, V.M.; Moritz, R.L.; Hood, L.*Journal of Proteome Research, 2013, 12 (5), 2034–2044.Highlighted in Genome Science, Proteomonitor, the noted publication. N-glycoproteome of E14.Tg2a mouse embryonic stem cellsSun, B.*; Ma, L.; Yan, X.; Lee, D.; Alexander, V.; Hohmann, L. J.; Lorang, C.; Chandrasena, L.; Tian, Q.; Hood, L.*PLOS ONE, 2013, 8(2): e55722. doi: 10.1371/journal.pone.0055722. Highlighted in Science Daily, “Discovering Cell Surface Proteins' Behavior”; Proteomonitor: “SFU Team Profiles N-Glycoproteome of Mouse Stem Cells, IDs Membrane Protein Glycosylation Pattern”;ACCN, the Canadian Chemical News: “Glycan capture technique sheds light on cell surface proteins” and by LC & GC chromatography online:“How do cells talk?” Molecular Profiling of Stem CellsLi, M.; Sun, B.; Hood, L.; Tian, Q.*Clinica Chimica Acta, 2007, 378, 24-32. Shotgun Glycopeptide-Capture Approach Coupled with Mass Spectrometry for Comprehensive GlycoproteomicsSun, B.; Ranish, J. A.; Utleg, A. G.; White, J. T.; Yan, X.; Lin, B; Hood, L.*Mol. Cell. Proteomics, 2007, 6, 141-149. Highlighted in Journal of Proteome Research, “Isolating the glycoproteome from the bottom up”, 2007, 6, 17-19, doi: 10.1021/pr0707051; by Functional Glycomics, “One pot, one shot”, 2007, February 08, doi:10.1038/fg.2007.7 Layered Polyelectrolyte-Silica Coating for NanocapsulesSun, B.; Mutch, S.; Lorenz, R.; Chiu, D. T.*Langmuir, 2005, 21, 10763-10769. Determination of the Encapsulation Efficiency of Individual Vesicles Using Single-Vesicle Photolysis and Confocal Single-Molecule DetectionSun, B. and Chiu, D. T.*Anal. Chem., 2005, 77, 2770-2776. Fast Initiation of Chemical Reactions with Laser-Induced Breakdown of a Nanoscale Partition Sun, B.; Lim, S. D.; Kuo, J. S.; Kuyper, C. L.; Chiu, D. T.*Langmuir, 2004, 20, 9437-9440. Synthesis, Loading, and Application of Individual Nanocapsules for Probing Single-Cell SignalingSun, B.; and Chiu, D. T.*Langmuir, 2004, 20, 4614-4620. Spatially and Temporally Resolved Delivery of Stimuli to Single CellsSun, B.; and Chiu, D. T.*J. Am. Chem. Soc. 2003, 125, 3702-3703. Functional mapping of cell surface proteins with localized stimulation of single cellsSun, B.; and Chiu, D. T.*The Proceedings of SPIE, 2003, 5222 (Nanocrystals and Organic and Hybrid Nanomaterials), 118-125. Kinetic studies on the oxidation of cytochrome b(5) Phe35 mutants with cytochrome c, plastocyanin and inorganic complexesYao, P.; Wang, Y. H.; Sun, B.; Xie, Y.; Hirota, S.; Yamauchi, O.; Huang, Z. X.*J. Biol. Inorg. Chem. 2002, 7, 375-383.