个人简介

B.Sc. & Ph.D. - Simon Fraser University Postdoctoral Fellow - University of Toronto Postdoctoral Fellow - University of Utah

研究领域

Bioorganic Chemistry

Bio-Organic Chemistry molecular recognition, binding protein, pheromone, olfaction, enzyme, monooxygenase Pheromone olfaction in the gypsy moth. The pheromone olfactory system in moths is one of the most sensitive detectors in nature. We are interested in studying proteins from the olfactory system that interact with the pheromone. This molecular interaction ultimately leads to odour discrimination and to the exquisite sensitivity of the olfactory system. In particular, we address the molecular recognition of stereochemical features of signal chemicals. In the long term, we are interested in designing pheromone mimics that will specifically interfere with pheromone olfaction. Such compounds could be used in pest control. Cytochrome P450 in synthesis. Cytochromes P450 are pigmented proteins that participate in many important metabolic processes, most of which involve oxidation of an organic substrate by dioxygen from air. Some cytochromes P450 catalyze the insertion of oxygen-containing groups into inert hydrocarbon structures, a reaction that is potentially very useful in laboratory synthesis. We are interested in the alteration of bacterial cytochromes P450, such that the new enzymes can be used with synthetically relevant non-natural substrates.

近期论文

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Y. Gong, E. Plettner, Effects of Aromatic Compounds on Antennal Responses and on the Pheromone-Binding Proteins of the Gypsy Moth (Lymantria dispar),Chem. Senses201136, 291-300. B. Prasad, A. R. Lewis, E. Plettner, Enrichment of H217O from Tap Water, Characterization of the Enriched Water and Properties of Several 17O-Labeled Compounds,Anal. Chem.,2011,83, 231–239. B. Prasad, A. Rojubally, E. Plettner, Identification of camphoroxidation and reduction products in Pseudomonas putida. New activity of the cytochrome P450cam system.,J. Chem. Ecol.,2011,37, 657–667. Y. Gong, H. Tang, C. Bohne, E. Plettner. , Binding Conformation and Kinetics of Two Pheromone-Binding Proteins from the Gypsy Moth, L. dispar with Biological and Non-Biological Ligands. Biochemistry,2010,49, 793-801. H. Chen, Y. Gong, R. M. Gries, E. Plettner. , Synthesis and biological activity of conformationally restricted gypsy moth pheromone mimics.,Bioorganic& Medicinal Chemistry,2010,18, 2920-2929. E. Plettner and R. M. Gries., Agonists and antagonists of antennal responses of gypsy moth (Lymantria dispar) to the pheromone (+)-disparlure and other odorants.,J. Agric. and Food Chem.,2010,58, 3708-3719. Y. Akhtar, Y. Yu, M. B. Isman and E. Plettner. , Dialkoxybenzene and Dialkoxy-Allylbenzene Feeding and Oviposition Deterrents against the Cabbage Looper, Trichoplusia ni: Potential Insect Behavior Control Agents. ,J. Agric. and Food Chem.,2010,58, 4983–4991. C. Dussaubat, A. Maisonnasse, C. Alaux, S. Tchamitchan, J.-L. Brunet, E. Plettner, L. P. Belzunces, Y. Le Conte., Nosema spp. Infection Alters Pheromone Production in Honey Bees (Apis mellifera).,J. Chem. Ecol.,2010,36, 522–525. A. Maisonnasse, C. Alaux, D. Beslay, D. Crauser, C. Gines, E. Plettner, Y. Le Conte. , New insights into honey bee (Apis mellifera) pheromone communication. Is the queen mandibular pheromone alone in colony regulation?,Frontiers in Zoology,2010,7, 18-25. Y. Gong, T. C. S. Pace, C. Castillo, C. Bohne, M. A. O’Neill, E. Plettner., Ligand-Interaction Kinetics of the Pheromone-Binding Protein from the Gypsy Moth, L. dispar: Insights into the Mechanism of Binding and Release. ,Chemistry & Biology,2009,16, 162-172. H. Chen, S. Nagabandi, S. Smith, J. M. Goodman, E. Plettner., A route to optically pure 5-(2’-hydroxyethyl)cyclopent-2-en-1-ol and its absolute configuration by Mosher esters. ,Tetrahedron Asymmetry,2009,20, 449-456. A. Maisonnasse, J.-C. Lenoir, G. Costagliola, D. Beslay, F. Choteau, D. Crauser, J.-M. Becard, E. Plettner and Y. Le Conte., A scientific note on E-β-ocimene, a new volatile primer pheromone that inhibits worker ovary development in honey bees. ,Apidologie,2009,40, 562–564. P. M. Paduraru,R. Nair, R. T. W. Popoff, R. Gries, G. Gries, E. Plettner., Synthesis of Substituted Alkoxy Benzene Minilibraries, for the Discovery of New Insect Olfaction of Gustation Inhibitors,J. Combin. Chem.,2008,10, 123-134. A. Rojubally, S.-H. Cheng, C. Foreman, J. Huang, G. R. Agnes, E. Plettner., Linking of Cytochrome P450cam and Putidaredoxin by a Coordination Bridge.,Biocatalysis and Biotransformation,2007,25, 301-317. Y. Akhtar, M. B. Isman, P. M. Paduraru, S. Nagabandi, R. Nair, E. Plettner. , Screening of Dialkoxy Benzenes and Disubstituted Cyclopentene Derivatives against a Noctuid Caterpillar Trichoplusia ni, for the Discovery of New Feeding and Oviposition Deterrents,J. Agric. Food Chem.,2007,55, 10323 -10330. Yves Le Conte, Jean-Marc Bécard, Guy Costagliola, Gérard de Vaublanc, Mohammed El Maataoui, Didier Crauser, Erika Plettner and Keith Slessor., Source of primer and releaser pheromone in the honey bee larvae (Apis mellifera L.),Naturwissenschaften,2006,93, 237-241. N. S. Honson, E. Plettner. , Structure and Reactivity of Disulfide Bridges in Insect Pheromone Binding Proteins. ,Naturwissenschaften,2006,93, 267-277. K. W. Wanner, D. A. Theilmann, M. B. Isman, Q. Feng, E. Plettner., Developmental expression patterns of four chemosensory protein genes from the Eastern spruce budworm, Chorsitoneura fumiferana.,Insect Mol. Biol.,2005,14, 289-300. N. S. Honson, Y. Gong, E. Plettner. , Structure and Function of Insect Odorant and Pheromone-Binding Proteins (OBPs and PBPs) and Chemosensory-Specific Proteins (CSPs).,Recent Advances in Phytochemistry,2005,39, 268-277. E. Plettner, A. Mohle, M. T. Mwangi, J. Griscti, B. O. Patrick, R. Nair, R. J. Batchelor and F. Einstein., 2-Chlorobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2-Chlorobicyclo[2.2.1]heptane-2-carboxamide as Precursors of Bicyclo[2.2.1]hept-5-en-2-one and Bicyclo [2.2.1]heptan-2-one. Resolution, Absolute Configuration and Hydrogen-bonding Properties.,Tetrahedron Asymmetry,2005,16, 2754-2763. J. A. H. Inkster, L. Jacquet, I. Ling, N. S. Honson, R. Gries, E. Plettner., Synthesis of disparlure analogs, using resolution on microcrystalline cellulose triacetate I. ,Tetrahedron Asymmetry,2005,16, 3773-3784