个人简介

B.Sc. - University of Hong Kong M.Sc. & Ph.D. - University of Toronto

研究领域

Bioanalytical Chemistry

Bioanalytical Chemistry Single-cell assay, nanomaterial-based DNA assays, chemical analysis of herbal compounds. We are interested in carrying out various chemical and biochemical analysis which are enhanced by the use of modern analytical techniques and microfluidic nanotechnology. In particular, we are interested in: Single-cell drug assays. DNA/RNA hybridization for biospecies identification. Chemical separations for nutritional, pharmaceutical and environmental applications. Our research goals are: To enhance various chemical and biochemical analysis by using nanomaterials so that analysis can be achieved more efficiently and effectively.

近期论文

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Khamenehfar, Avid; Gandhi, Maher; Chen, Yuchun; Hogge, Donna; Li, Paul, "Dielectrophoretic Microfluidic Chip Enables Single-Cell Measurements for Multidrug Resistance in Heterogeneous Acute Myeloid Leukemia Patient Samples", Anal. Chem. 2016, 88, 5680-5688. Sedighi, Abootaleb; Qiu, Shuang; Wong , Michael ; Li, Paul, "Dip-in indicators for visual differentiation of fuel mixtures based on wettability of fluoroalkylchlorosilane-coated inverse opal films", ACS Applied Materials & Interfaces, 2015, 7, 28387-28392. Abootaleb Sedighi, Vicki Whitehall, Paul C.H. Li, “Enhanced destabilization of mismatched DNA using gold nanoparticles offers specificity without compromising sensitivity for nucleic acid analyses”, Nano Research, 2015, 8, 3922-3933. Avid Khamenehfar,T.V.Beischlag,P.Russel,P.Ling,C.Nelson,and P.C.H.Li , “Label-free Isolation of a Prostate Cancer Cell among Blood Cells and the Single-Cell Measurement of Drug Accumulation Using an Integrated Microfluidic Chip”, Biomicrofluidics, 2015, 9, 064104, 1-18. Paul C.H. Li, Abootaleb Sedighi, Lin Wang eds. Microarray Technology and its Applications in Methods in Molecular Biology Series, Springer, 2016. Somewhere Fiel, Hua Yang, Paul Schaffer, Samuel Weng, James Inkster, Michael Wong, Paul C.H. Li, "Magnetic Droplet Microfluidics as a platform for the concentration of [18F]Fluoride and Radiosynthesis of Sulfonyl [18F]Fluoride", ACS Applied Materials & Interfaces, 2015, 7, 12923-12929. Yue Sun,Yuanyuan Li, Jiajian Zeng, Qixian Lu, Paul C.H. Li, “Microchip electrophoretic separation and fluorescence detection of chelerythrine and sanguinarine in medicinal plants”, Talanta, 2015, 142, 90–96. Abootaleb Sedighi, Paul C. H. Li, Idah C. Pekcevik, and Byron D. Gates, “A Proposed Mechanism of the Influence of Gold Nanoparticles on DNA Hybridization”, ACS Nano, 2014, 8, 6765-6777. Avid Khamenehfar, Chung Ping Leon Wan, Paul C. H. Li, Kevin Letchford, Helen M. Burt, “Same-single-cell analysis using the microfluidic biochip to reveal drug accumulation enhancement by an amphiphilic diblock copolymer drug formulation”, Anal, Bioanal, Chem. 2014, 406, 7071-7083. X.J. Li, Paul C.H. Li, “Cytosolic Calcium Measurement for Single-Cell Drug Efficacy and Cardiotoxicity Evaluations using Microfluidic Biochips”, Can. J Pure & Appl. Sci, 2014, 8, 2663-2669. F. Shen, X.J. Li, P. C. H. Li, “Study of flow behaviors on single-cell manipulation and shear stress reduction in microfluidic chips using CFD simulations”, Biomicrofluidics, 2014, 8, 014109, 1-12. Linda Uhr, Yuchun Chen, Daniel Sit and Paul C. H. Li "Ginsenosides in Commercial Ginseng Products Analyzed by Liquid Chromatography-tandem mass spectrometry," ISRN Anal. Chem. 2014, 486842, 1-8. Abootaleb Sedighi and Paul C.H. Li. Kras Gene codon 12 mutation detection enabled by Gold Nanoparticles conducted in a NanoBioArray chip. Anal. Biochem. 2014, 448, 58-64. Abootaleb Sedighi and Paul C.H. Li, “Challenges and future trends in DNA microarray analysis”, in Fundamentals of Advanced Omics Technologies, Elsevier’s Comprehensive Analytical Series, C. Simo, A. Cifuentes, V. Garcia-Fanas eds., Elsevier, 2014, 25-46. Abootaleb Sedighi, Lin Wang and Paul C.H. Li, “2D Nanofluidic Bioarray for Nucleic Acid Analysis” in Nanopatterning and Nanoscale Devices for Biological Applications, Taylor & Francis, K. Iniewski and S. Selimovic eds. 2013, 183-205. Yuchun Chen, Avid Khamenehfar, Paul C.H. Li, “Microfluidic same single cell analysis” in 2nd Edition of Encyclopedia of Microfluidics and Nanofluidics, Dongqing Li ed. Sprin