个人简介

UMASS Amherst (Prof. Robert Lenz) BioMacromolecules 1986-1988 Polytechnic University (Prof. Mark Green) Chemistry Ph.D. 1986 SUNY Albany Chemistry B.S. 1979

研究领域

Biotechnology/Materials

iocatalysis encompasses a wide platform of chemistries that afford opportunities for innovative new products and processes. Hallmarks of biocatalysts are their ability to operate under mild conditions, with impressive selectivity, on a diverse range of natural and non-natural substrates. Rapid advances in biotechnology continues to decrease the time and resources required to engineer organisms to produce desired products in high titers as well as to engineer enzymes with increased thermal stability, efficiency and specificity. Our group works with collaborators to apply existing, or develop new, biocatalytic methods that solve short or long term chemistry challenges. With sufficient focus on structure-property relationships of natural and biobased materials, they can become next-generation replacements for a wide array of currently used non-sustainable petroleum-derived materials. While most attention is focused on biomass for transportation fuels, less is paid to biomass as a source for organic chemicals including polymeric materials. This is true even though biomass-derived carbon can realistically replace most or possibly all nonfuel chemical uses, which comprise ~13% of the crude oil consumed by the U.S. today. Our program explores a wide range of opportunities for use in biobased replacements such as biobased and degradable polymers, biosurfactants, biofibers for commposite reinforcement and advanced materials opportunities such as in photovoltaic materials for energy harvesting; composite materials used, for example, in wind-blade turbines for wind energy harvesting, epoxies for circuit boards and much more.

近期论文

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Ganesh, Manoj; Nachman, Jonathan; Mao, Zhantong; Lyons, Alan; Rafailovich, Miriam; Gross, Richard A. “Patterned Enzymatic Degradation of Poly(ε-​caprolactone) by High-​Affinity Microcontact Printing and Polymer Pen Lithography” Biomacromolecules 14(8), 2470-2476 (2013). Xie, Wenchun; Teraoka, Iwao; Gross, Richard A. “Reversed phase ion-pairing chromatography of an oligolysine mixture in different mobile phases: Effort of searching critical chromatography conditions” Journal of Chromatography A 1304, 127-132 (2013). Celli, Annamaria; Marchese, Paola; Sullalti, Simone; Cai, Jiali; Gross, Richard A. “Aliphatic/aromatic copolyesters containing biobased ω-hydroxyfatty acids: Synthesis and structure-property relationships” Polymer, 54(15), 3774-3783 (2013). Peng, Yifeng; Decatur, John; Meier, Michael A. R. and Gross, Richard A. “Ring-Opening Metathesis Polymerization of a Naturally Derived Macrocyclic Glycolipid, Macromolecules, 46(9), 3293-3300 (2013). Qin, Xu; Wenchun, Xie; Tian, Sai; Yuan, Han; Yu, Zheng; Butterfoss, Glenn L.; Khuong, Anne C.; Gross, Richard A. “Enzyme-Triggered Hydrogelation via Self-Assembly of Alternating Peptides”, Chem. Commun., 49(42), 4839 – 4841 (2013). Zhang, Yu-Rong; Spinella, Stephen; Xie, Wenchun; Cai, Jiali; Yang, Yixin; Wang, Yu-Zhong; Gross, Richard A. “Polymeric triglyceride analogs prepared by enzyme-catalyzed condensation polymerization” European Polymer Journal, 49(4), 793-803 (2013). Zhu, Jianhui; Cai, Jiali; Xie, Wenchun; Chen, Pin-Hsuan; Gazzano, Massimo; Scandola, Mariastella; Gross, Richard A. “Poly(butylene 2,5-furan dicarboxylate), a Biobased Alternative to PBT: Synthesis, Physical Properties, and Crystal Structure” Macromolecules 46(3), 796-804 (2013). Qin, Xu; Khuong, Anne C.; Yu, Zheng; Du, Wenzhe; Decatur, John; Gross, Richard A. “Simplifying alternating peptide synthesis by protease-catalyzed dipeptide oligomerization” Chemical Communications 49(4), 385-387 (2013). Bhangale, Atul S.; Beers, Kathryn L.; Gross, Richard A.; “Enzyme-catalyzed polymerizations of end-functionalized polymers in a microreactor” Macromolecules 45:7000−7008 (2012) Ganesh, Manoj; Gross, Richard A. Enzymatic biomaterial degradation: Flow conditions & relative humidity, Polymer, 53:3454-3461 (2012) Viswanathan, Kodandaraman; Schofield, Mark H.; Teraoka, Iwao; Gross, Richard A. Surprising metal binding properties of phytochelatin-like peptides prepared by protease-catalysis, Green Chemistry, 14, 1020–1029 (2012). Baker, Peter James; Poultney, Christopher; Liu, Zhiqiang; Gross, Richard; Montclare, Jin Kim Identification and comparison of cutinases for synthetic polyester degradation, Appl Microbiol Biotechnol 93:229–240 (2012). Liu, Chen; Liu, Fei; Cai, Jiali; Xie, Wenchun; Long, Timothy E.; Turner, S. Richard; Lyons, Alan; Gross, Richard A. Polymers from Fatty Acids: Poly(ω-hydroxyl tetradecanoic acid) Synthesis and Physico-Mechanical Studies Biomacromolecules, 12(9), 3291-3298 (2011). Qin, Xu; Xie, Wenchun; Su, Qi; Du, Wenzhe; Gross, Richard A. Protease-catalyzed oligomerization of L-lysine ethyl ester in aqueous solution, ACS Catalysis, 1(9), 1022-1034 (2011). Liu, Jie; Jiang, Zhaozhong; Zhang, Shengmin; Liu, Chen; Gross, Richard A.; Kyriakides, Themis R.; Saltzman, W. Mark, Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters Biomaterials, 32(27), 6646-6654 (2011). Kundu, Santanu; Bhangale, Atul S.; Wallace, William E.; Flynn, Kathleen M.; Guttman, Charles M.; Gross, Richard A.; Beers, Kathryn L. “Continuous Flow Enzyme-Catalyzed Polymerization in a Microreactor” Journal of the American Chemical Society 133(15), 6006-6011 (2011) Yang, Yixin; Lu, Wenhua; Cai, Jiali; Hou, Yu; Ouyang, Suyang; Xie, Wenchun; Gross, Richard A. “Poly(oleic diacid-co-glycerol): comparison of polymer structure resulting from chemical and lipase catalysis” Macromolecules, 44(7), 1977-1985 (2011). Lu, Wen-Hua; Ness, Jon E.; Xie, Wen-Chun; Zhang, Xiao-Yan; Minshull, Jeremy; Gross, Richard A. “Biosynthesis of Monomers for Plastics from Renewable Oils” Journal of the American Chemical Society, 132(43), 15451-15455 (2010). Gualandi, Chiara; White, Lisa J.; Chen, Liu; Gross, Richard A.; Shakesheff, Kevin M.; Howdle, Steven M.; Scandola, Mariastella “Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester” Acta Biomaterialia, 6(1), 130-136 (2010). Focarete, Maria Letizia; Gualandi, Chiara; Scandola, Mariastella; Govoni, Marco; Giordano, Emanuele; Foroni, Laura; Valente, Sabrina; Pasquinelli, Gianandrea; Gao, Wei; Gross, Richard A. “Electrospun scaffolds of a polyhydroxyalkanoate consisting of ω-hydroxylpentadecanoate repeat units: fabrication and in vitro biocompatibility studies” Journal of Biomaterials Science, Polymer Edition, 21(10), 1283-1296 (2010). Viswanathan, Kodandaraman; Omorebokhae, Ruth; Li, Geng; Gross, Richard A. “Protease-Catalyzed Oligomerization of Hydrophobic Amino Acid Ethyl Esters in Homogeneous Reaction Media Using L-Phenylalanine as a Model System” Biomacromolecules, 11(8), 2152-2160 (2010). Gross, Richard A.; Ganesh, Manoj; Lu, Wenhua “Enzyme-catalysis breathes new life into polyester condensation polymerizations” Trends in Biotechnology, 28(8), 435-443 (2010). Viswanathan, Kodandaraman; Li, Geng; Gross, Richard A. “Protease catalyzed in situ C-terminal modification of oligoglutamate” Macromolecules, 43(12), 5245-5255(2010). Feder, David; Gross, Richard A. “Exploring Chain Length Selectivity in HiC-Catalyzed Polycondensation Reactions” Biomacromolecules, 11(3), 690-697 (2010). Liu, Z.; Gosser, Y.; Baker, P.J.; Ravee, Y.; Lu, Z.; Alemu, G.; Li, H.; Butterfoss, G.L. Kong, X.-P. Gross, R.A.; Montclare, J.K. “Structural and Functional Studies of Aspergillus oryzae Cutinase: Enhanced Thermostability and Hydrolytic Activity of Synthetic Ester and Polyester Degradation” J. Am. Chem. Soc., 131 (43), pp 15711–15716 (2009) Ganesh, M.; Dave, R.N.; L’Amoreaux, W.; Gross, R.A. “Embedded Enzymatic Biomaterial Degradation” Macromolecules, 42 (18), pp 6836–6839 (2009). Ronkvist, A.M.; Lu, W.; Feder, D.; Gross, R.A. “Cutinase-Catalyzed Deacetylation of Poly(vinyl acetate)” Macromolecules, 2009, 42 (16), 6086–6097 (2009) Ronkvist, A.M.; Xie, W.; Lu, W.; Gross, R.A. “Cutinase-Catalyzed Hydrolysis of Poly(ethylene terephthalate)” Macromolecules, 2009, 42 (14), pp 5128–5138 Sleiman J.N., Kohlhoff S.A., Roblin P.A., Wallner S., Gross R., Hammerschlag M.R., Bluth M.H. “Sophorolipids as Antimicrobials” Ann. Clin. Lab Sci 39(1) 60-63. Chen, B., Pernodet, N., Rafailovich, M.H., Bakhtina, A. and Gross, R.A. Protein immobilization on epoxy-activated thin polymer films: Effect of surface wettability and enzyme loading Langmuir 24 (23): 13457-13464(2008). Zini, E., Gazzano, M., Scandola, M., Wallner, S.R. and Gross, R. A. Glycolipid biomaterials: Solid-state properties of a poly(sophorolipid). Macromolecules 42(20): 7463-7468 (2008). Li, G., Raman, V.K., Xie, W.C. and Gross R.A. Protease-catalyzed co-oligomerizations of L-leucine ethyl ester with L-glutamic acid diethyl ester: Sequence and chain length distributions. Macromolecules 41 (19): 7003-7012 (2008). Fu, S.L., Wallner, S.R., Bowne, W.B., Hagler, M.D., Zenilman, M.E., Gross, R.A. and Bluth, M.H. Sophorolipids and their derivatives are lethal against human pancreatic cancer cells. Journal of Surgical Research 148 (1): 77-82 (2008). Chen, B., Hu, J., Miller, E.M., Xie, W.H., Cai, M.M. and Gross, R.A. Candida antarctica lipase B chemically immobilized on epoxy-activated micro- and nanobeads: Catalysts for polyester synthesis. Biomacromolecules 9: 463-471(2008). Dodds, D. R. and Gross, R. A. Chemicals from biomass. Science 318 (5854): 1250-1251 (2007). Hardin, R., Pierre, J., Schulze, R., Mueller, C. M., Fu, S. L., Wallner, S. R., Stanek, A., Shah, V., Gross, R. A., Weedon, J., Nowakowski, M., Zenilman, M. E. and Bluth, M. H. Sophorolipids improve sepsis survival: Effects of dosing and derivatives. Journal of Surgical Research 142 (2): 314-319 (2007). Fu, S. L., Mueller, C., Lin, Y. Y., Viterbo, D., Pierre, J., Shah, V., Gross, R., Schulze, R. and Zenilman, M. Sophorolipid treatment decreases LIPS induced inflammatory responses and NO production in macrophages. Journal of the American College of Surgeons 205 (3): S44-S44 (2007). Kulshrestha, A. S., Gao, W., Fu, H. Y. and Gross, R. A. Synthesis and characterization of branched polymers from lipase-catalyzed trimethylolpropane copolymerizations. Biomacromolecules 8 (6): 1794-1801 (2007). Chen, B., Miller, M. E. and Gross, R. A. Effects of porous polystyrene resin parameters on Candida antarctica Lipase B adsorption, distribution, and polyester synthesis activity. Langmuir 23 (11): 6467-6474 (2007). Li, G., Vaidya, A., Viswanathan, K., Cui, J.R., Xie, W.C., Gao, W. and Gross, R.A. Rapid regioselective oligomerization of L-glutamic acid diethyl ester catalyzed by papain, Macromolecules 39 (23): 7915-7921 (2006) Bluth, M.H., Kandil, E., Mueller, C.M., Shah, V., Lin, Y.Y., Zhang, H., Dresner, L., Lempert, L., Nowakowski, M., Gross, R.A., Schulze, R. and Zenilman, M.E. Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis. Critical Care Medicine 34 (1): 188-195 (2006) Mueller, C.M., Viterbo, D., Murray, P.J., Shah, V., Gross, R.A., Schulze, R., Zenilman, M.E. and Bluth, M.H. Sophorolipid treatment decreases inflammatory cytokine expression in an in vitro model of experimental sepsis. Faseb Journal 20 (4): A204-A204 Part 1, (2006). Shah V, Doncel GF, Seyoum T, Eaton KM, Zalenskaya I, Hagver R, Azim A, Gross R. Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities. Antimicrob Agents Chemother; 149; 1-8 (2005). Sahoo, B.; Brandstadt, K. F.; Lane, T. H.; Gross, R. A. “Sweet Silicones": Biocatalytic Reactions to Form Organosilicon Carbohydrate Macromers Org. Lett.; 7(18); 3857-3860 (2005). Loos, K.; Kennedy, S. B.; Eidelman, N.; Tai, Y.; Zharnikov, M.; Amis, E. J.; Ulman, A.; Gross, R. A. Combinatorial Approach To Study Enzyme/Surface Interactions Langmuir; 21(12); 5237-5241 (2005). Kulshrestha, A. S.; Gao, W.; Gross, R.A. “Glycerol Copolyesters: Control of Branching and Molecular Weight Using a Lipase Catalyst”, Macromolecules, (2005); 38(8); 3193-3204 Zhang, L., Somasundaran, P., Singh, S. K., Felse, A. P., Gross, R.A. Synthesis and interfacial properties of sophorolipid derivatives Colloids and Surfaces A: Physicochem.Eng. Aspects; 240; 75-82 (2004) Zhou, S., Xu, Chang.., Wang, J., Gao, W., Akhverdiyeva., Shah, V., Gross, R. A. Supramolecular Assembles of a Naturally Derived Sopholipid. Langmuir; 20; 7926-7932 (2004) Mei, Y., Kumar, A, Gao, W, Gross, R.A., Kennedy, S.B., Washburn, N.R., Amis, E,.J., Elliot, John T. Biocompatibility of sorbitol-containing polyesters. Part 1: Synthesis, surface analysis and cell response in vitro; Biomaterials; 25; 4195-4201 (2004) Singh, S,K, Felse, A. P., Nunez, A., Foglia, T.A. and Gross, R.A. Regioselective Enzyme-Catalyzed Synthesis of Sophorolipid Esters, Amides and Multifunctional Monomers. J. Org. Chem.; 68; 5466-5477 (2003) Kumar, A.; Kulshrestha, A. S.; Gao, W.; Gross, R. A.; Versatile Route to Polyol Polyesters by Lipase Catalysis Macromolecules; 36(22); 8219-8221 (2003). Mei, Y.; Miller, L.; Gao, W.; Gross, R. A.; Imaging the Distribution and Secondary Structure of Immobilized Enzymes Using Infrared Microspectroscopy Biomacromolecules; 4(1); 70-74 (2003). Dyal, A., Loos, Katja., Noto, M., Chang, S.W., Spagnoli, C., Shafi, Kurikka V.P.M., Ulman, A., Cowman,M.,Gross. R.A. Activity of Candida rugosa Lipase Immobilized on g-Fe2O3 Magnetic Nanoparticles J. Am. Chem. Soc.; 125; 1684-1685 (2003). Mei, Y, Kumar, A, Gross; R.A., “Kinetics and Mechanism of Candida antarctica Lipase B Catalyzed Solution Polymerization of ε-Caprolactone”, Macromolecules; 36(15); 5530-5536 (2003). Gross, R. A., Kalra, B; “Biodegradable Polymers for the Environment”, Science, 297, 803-806 (2002). R. Kumar and R.A. Gross, “Biocatalytic Route to Well-Defined Macromers Built around a Sugar Core, J. Am. Chem. Soc., 124(9) (2002). V Guilmanov, A Ballistreri, G Impallomeni, R.A. Gross, “Oxygen Transfer Rate and Sophorose Lipid Production by Candida bombicola”, Biotechnol. and Bioeng; 77(5), 489-494 (2002) R. A. Gross, A Kumar, B Kalra, "In-vitro Enzyme Catalyzed Polymer Synthesis", Chemical Reviews, 101(7), 2097-2124 (2001). J.W. Lee, F. Dang, W.G. Yeomans, A.L. Allen, R.A. Gross, D.L. Kaplan, “Acetobacter xylinium ATCC 10245: Production of Chitosan-Cellulose and Chitin-Cellulose Exopolymers, Applied and Environmental Microbiology, 67(9), 3970-3975 (2001). A Kumar, R.A Gross, “Lipase-Catalyzed Transesterification: New Synthetic Routes To Copolyesters”, J. Am. Chem. Soc.; 122; 11767-11770 (2000).