个人简介

B.Sc. (Hons), University of Waterloo (1996) Ph.D., University of British Columbia (2002) NSERC Postdoctoral Fellow, University of Cambridge (2002-2004)

研究领域

Natural Product Chemistry

Natural Product Chemistry total synthesis, method development, J-based configuration/conformation analysis, structure activity relationship studies The primary focus of our research program is the development of novel synthetic transformations and their subsequent application in the stereocontrolled synthesis of natural products with potentially useful biological activity. A certain corollary of these pursuits involves studies directed at probing the relationship between structure and/or conformation and biological function. Examples of natural products currently targeted by our group include the latrunculins (e.g. latrunculin A) microfilament-disrupting agents that have been highlighted as potential lead compounds for cancer therapy; chimonanthine, an alkaloid that has attracted attention as a potential modulator of pain; and eleutherobin, a soft-coral derived diterpene glycoside with antimitotic activity similar to that of taxol.

近期论文

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Michael Meanwell, Matthew B. Nodwell, Rainer E. Martin, Robert Britton ‘A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N-Fluorobenzenesulfonimide’ Angewandte Chemie, International Edition, 2016, 55 (42), 13244-13248. 56. Huimin Zhai, Michael Hrabar, Regine Gries, Gerhard Gries,Robert Britton ' ‘Total Synthesis, Stereochemical Assignment, and Field-Testing of the Sex Pheromone of the Strepsipteran Xenos peckii’.Chemistry: A European Journal, 2016, 22 (18), 6190-6193. 55. Milan Bergeron-Brlek, Jake Goodwin-Tindall, Nevena Cekic, Christian Roth, Wesley F. Zandberg, Xiaoyang Shan, Vimal Varghese, Sherry Chan, Gideon J. Davies, David J. Vocadlo, Robert Britton 'A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors' Angewandte Chemie, International Edition, 2015, 54 (51), 15429-15433. 54. Shira D. Halperin, Daniel Kwon, Michael Holmes, Erik L. Regalado, Louis-Charles Campeau, Daniel A. DiRocco, Robert Britton 'Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib' Org Lett, 2015, 17 (21), 5200-5203. 53. Stanley Chang, Soo Hur, Robert Britton 'Total Synthesis and Configurational Assignment of Ascospiroketal A'' Chemistry - A European Journal, 2015, 21 (46), 16646-16653. 52. Michael Hrabar, Huimin Zhai, Regine Gries, Paul W. Schaefer, Jason Draper, Robert Britton, Gerhard Gries '(7E,11E)-3,5,9,11-Tetramethyltridecadienal: Sex Pheromone of the Strepsipteran Xenos peckii' Journal of Chemical Ecology, 2015, 41 (8), 732-739. 51. Michael Holmes, Daniel Kwon, Matthew Taron, Robert Britton 'Total Synthesis of Amphirionin-4' Org Lett, 2015, 17 (15), 3868-3871. 50. Matthew B. Nodwell, Abhimanyu Bagai, Shira D. Halperin, Rainer E. Martin, Henner Knust, Robert Britton 'Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide' Chemical Communications, 2015, 51, 11783-11786. 49. Milan Bergeron-Brlek, Michael Meanwell, Robert Britton 'Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars' Nature Communications, 2015, 6, 6903. 48. Regine Gries, Robert Britton, Michael Holmes, Huimin Zhai, Jason Draper, Gerhard Gries 'Bed Bug Aggregation Pheromone Finally Identified' Angewandte Chemie, International Edition, 2015, 54, 1135. 47. Stanley Chang, Soo Hur, Robert Britton 'Total Synthesis of Ascospiroketal A Through a Ag(I)-Promoted Cyclization Cascade' Angewandte Chemie, International Edition, 2015, 54, 211. 46. Shira D. Halperin, Hope Fan, Stanley Chang, Rainer E. Martin, Robert Britton 'A Convenient Photocatalytic Fluorination of Unactivated C-H Bonds' Angewandte Chemie, International Edition, 2014, 53, 4690. 45. Thibaut Alzieu, Johannes Lehmann, Ajay B. Naidu, Rainer E. Martin, Robert Britton 'Converting Oxazoles Into Imidazoles: New Opportunities for Diversity-oriented Synthesis' Chemical Communications, 2014, 50, 1867. 44. Zena Qadoumi, James Senior, Milan Bergeron-Brlek, Robert Britton 'Direct Access to Iminosugars through an Interrupted Kondrat'eva Reaction' Synlett, 2013, 24, 2427. 43. Michael T. Holmes, Robert Britton 'Total Synthesis and Structural Revision of Laurefurenynes A and B' Chemistry - A European Journal, 2013, 19, 12649. 42. Vijay Dhand, Stanley Chang, Robert Britton 'Total Synthesis of the Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B)' Journal of Organic Chemistry, 2013, 78, 8208. 41. Milan Bergeron-Brlek, Timothy Teoh, Robert Britton 'A Tandem Organocatalytic a-Chlorination-Aldol Reaction That Proceeds with Dynamic Kinetic Resolution: A Powerful Tool for Carbohydrate Synthesis' Organic Letters, 2013, 15, 3554. 40. Johannes Lehmann, Thibaut Alzieu, Rainer E. Martin, Robert Britton 'The Kondrat'eva Reaction in Flow: Direct Access to Annulated Pyridines' Organic Letters, 2013, 15, 3550. 39. Stanley Chang, Saheena Desai, Daniel B. Leznoff, Nabyl Merbouh, Robert Britton 'A Short, Gram-Scale Synthesis of 2,5-Disubstituted Furans' European Journal of Organic Chemistry, 2013, 3219. 38. Vijay Dhand, Jason A. Draper, Jarod Moore, Robert Britton 'A Short, Organocatalytic Formal Synthesis of (-)-Swainsonine and Related Alkaloids' Organic Letters, 2013, 15, 1914.