个人简介

B.Sc., University of Waterloo (1989) Ph.D., University of Alberta (1994)

研究领域

Analytical Chemistry

Analytical Chemistry levitation of droplets and particles, chemical speciation, mass spectrometry, ion sources, biological applications of mass spectrometry, proteomics, atmospheric chemistry, heterogeneous chemistry The Agnes group is continuing to develop the analytical aspects of a novel picoliter sample handling strategy that they introduced as 'Wall-less Sample Preparation' (WaSP). In addition to this aspect of the Agnes group's program of research, there is a strong commitment to apply the WaSP technology to the chemistry of trace components in levitated picoliter droplets/particles. Example applications include heterogeneous and homogeneous reactions on suspended particles that are of relevance to the troposphere, metal-organic chemistry within the environment of a levitated droplet/particle, and investigation of biological compounds at sub-nanomolar concentrations in physiological fluids of relevance to human health and disease.

近期论文

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23. Bogan, M. J.; Bakhoum, S. F. W.; Agnes, G. R. Promotion of alpha-cyano-4-hydroxycinnammic acid and Peptide Co-crystallization within Levitated Droplets with Net Charge, J. Am. Soc. Mass Spectrom., In press. 22. Haddrell, A. E.; Feng, X.; Nassar, R.; Bogan, M. J.; Agnes, G. R. Off-line LDI-TOF-MS Monitoring of Simultaneous Inorganic and Organic Reactions on Particles Levitated in a Laboratory Environment, J. Aerosol Sci., In press. 21. Bogan, M. J.; Agnes, G. R. Electrodynamic charged droplet processing to couple capillary liquid chromatography with offline matrix-assisted laser desorption/ionization mass spectrometry, Rapid Commun. Mass Spectrom., 2004, 18, 2673-2681. 20. Bogan, Michael J.; Agnes, George R.. Wall-less sample preparation of mm-sized sample spots for femtomole detection limits of proteins from liquid based UV-MALDI matrices. J. Am. Soc. Mass Spectrom., 2004, 15(4), 486-495. 19. Haddrell, Allen E.; Agnes, George R.. A class of heterogeneous/multiphase organic reactions studied on droplets/particles levitated in a laboratory environment: aldehyde + 1,8-diaminonaphthalene=imine. Atmospheric Environment, 2004, 38(4), 545-556. 18. Haddrell, Allen E.; Agnes, George R.. Organic Cation Distributions in the Residues of Levitated Droplets with Net Charge: Validity of the Partition Theory for Droplets Produced by an Electrospray. Anal. Chem., 2004, 76(1), 53-61. 17. Bogan, Michael J.; Agnes, George R.. Time-of-flight mass spectrometric analysis of ions produced from adjacent sample spots irradiated simultaneously by a single 337 nm laser. Rapid Commun. Mass Spectrom., 2003, 17(22), 2557-2562. 16. Verge, K. M; Agnes, G. R. Plasticizer contamination from vacuum system O-rings in a quadrupole ion trap mass spectrometer, J. Am. Soc. Mass Spectrom., 2002, 18, 901-905. 15. Bogan, M. J.; Agnes, G. R. MALDI-TOF-MS analysis of droplets prepared in an electrodynamic balance: 'wall-less' sample preparation, Anal. Chem., 2002, 74, 489-496. 14. Bogan, M. J.; Agnes, G. R. Poly(ethylene glycol) doubly and singly cationized by different alkali metal ions: Relative cation affinities and cation-dependent resolution in a quadrupole ion trap mass spectrometer, J. Am. Soc. Mass Spectrom., 2002, 13, 177-186. 13. Feng, X.; Bogan, M. J.; Agnes, G. R. Coulomb fission resolved progeny droplet production from isolated evaporating methanol droplets, Anal. Chem., 2001, 73, 4499-4507. 12. Feng, X.; Bogan, M.; Chuah, E.; Agnes, G. R. Micro-heterogeneous catalysis at the surface of electrodynamically levitated particles, J. Aerosol Sci., 2001, 32, 1147-1159. 11. Xu, J. Q.; Balik, D.; Agnes, G. R. Aerosol static electrification and its effect in inductively coupled plasma spectroscopy, J. Anal. At. Spectrom., 2001, 16, 715-723. 10. Feng, X.; Agnes, G. R. Single Isolated Droplets with Net Charge as a Source of Ions, J. Am. Soc. Mass Spectrom., 2000, 11, 393-399. 9. Xu, Q; Agnes, G. R. Use of laser scatter signals to study the effect of a DC biased mesh screen in a spray chamber on aerosols generated for use in atomic spectrometry, Appl. Spectrosc., 1999, 54(1), 94-98. 8. Wang, H. J.; Agnes, G. R. Kinetically labile equilibrium shifts induced by the electrospray process, Anal. Chem., 1999, 71(19), 4166-4172. 7. Wang, H. J.; Agnes, G. R. Evaluation of electrospray mass spectrometry as a technique for quantitative analysis of kinetically labile solution species, Anal. Chem., 1999, 71(17), 3785-3792. 6. Xu, Q; Agnes, G. R. Influence of droplets with net charge in inductively coupled plasma atomic emission spectroscopy and implications for the easily ionizable element chemical matrix effect, Appl. Spectrosc., 1999, 53(8), 965-973. 5. Agnes, G. R.; Horlick, G. Effect of Operating Parameters on Analyte Signals in Elemental Electrospray Mass Spectrometry, Appl. Spectrosc., 1995, 49(3), 324-334. 4. Agnes, G. R.; Stewart, I. I.; Horlick, G. Elemental Speciation Measurements with Electrospray Mass Spectrometry: An Assessment, Appl. Spectrosc., 1994, 48(11), 1347-1361.