个人简介

B.Sc. (Cell Biology, Hons) University of Saskatchewan, 1972 Ph.D. (Cell Biology) University of Toronto, 1976 NSERC Post-doctorate (Cancer Biology) University of British Columbia, 1977-79 Sabbatical (Head & Neck Cancer) Johns Hopkins University, 1994-95 Sabbatical (Proteomics Genomic Instability) Karolinska Institute 2005

研究领域

Identification of Molecular Alterations Predicting Cancer Development

Visualization for detection of cancers Development of new optical devices and computer imaging platforms to predict progression for oral premalignant lesions: A key barrier to the management of premalignant disease is the lack of tools that can guide decision to biopsy. One of Dr. Rosin's key research projects focuses on developing and validating tissue optical tools that can be used to facilitate the visualization of changes in the oral mucosa that require further assessment by biopsy. A parallel development involves the training of high resolution computerized microscopy systems to identify subtle alterations in the cells of cancers and premalignant disease obtained with such visualization tools. Supported by NIH/NIDCR. Biomarkers for carcinogenesis The identification of novel genes and chromosomal regions that regulate normal oral epithelial cell behavior and that are altered in early premalignant lesions: Identifying biomarkers for risk prediction for early premalignant lesions better guides the clinician in identifying changes to the tissue that are associated with a high likelihood of oral cancer development 5-10 years prior to its occurrence. This allows for early intervention in the disease. We are identifying and assessing such markers within a large ongoing longitudinal study of ~700 patients. Supported by NIH/NIDCR. Community outreach for oral cancer prevention Knowledge transfer to community dentists: Technology developed within the BC Oral Cancer Prevention Program for the purpose of early oral cancer detection is now being transferred into community dental practices. This process is ongoing in BC with several cohorts of community dentists now evaluating new technology on patients during regular hygiene recall exams. The data being generated in these studies is being published within key dental journals to guide the uptake and dissemination of new technology. Supported by BC Cancer Foundation High-risk underserved populations: This project is assessing the oral cancer-related needs of high-risk communities, identifying facilitators and barriers to oral cancer control. We have identified 4 groups as a focus: South Asian immigrants, the Vancouver Downtown Eastside (DTES), Aboriginal communities, and those geographically distant from cancer control services in rural and remote regions of BC. These groups represent vulnerable communities comprised of individuals with low socioeconomic status, different ethnic backgrounds, or residing in different geographic regions where risk factors, barriers to accessing services, and disease incidence are much higher. Supported by CIHR and the BC Cancer Foundation

近期论文

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Auluck, A., Hislop, G., Poh, C., Zhang, L., and Rosin, M.P. Areca nut and betel quid chewing among south Asian immigrants to western countries and its implications for oral cancer screening. Rural Remote Health. 2009 Apr-Jun;9(2):1118 (2009) PMID:19445556. Poh, C.F., MacAulay, C.E., Zhang, L., and Rosin, M.P. Tracing the "at-risk" oral mucosa field with autofluorescence: Steps toward clinical impact. Can Prev Res. 2009 May;2(5):401-4 (2009) PMID: 19401533. Tsui, I.F.L., Rosin, M.P., Zhang, L., Ng, R.T., and Lam, W. Multiple aberrations of chromosome 3p detected in oral premalignant lesions. Cancer Prev Res (Phila Pa). 2008 Nov;1(6):424-9 (2008) PMID: 19138989. Auluck, A., Rosin, M.P., and Hislop, G. Oral cancer awareness among immigrant Indo-Canadian community of Vancouver, BC. Rural Remote Health. 2008 Apr-Jun;8(2):1004 (2008) PMID:18473667. Poh, C.F., Hislop, G., Currie, B., Lee, R., Sikorski, S., Zed, C., Zhang, L., Macaulay, C., and Rosin, M.P. Oral cancer screening in a high-risk underserved community--Vancouver downtown eastside. J Health Care Poor Underserved. 18(4):767-78 (2007) PMID:17982206. Rosin, M.P., Poh, C.F., Guillard, M., Williams, P.M., Zhang, L., and MacaUlay, C. Visualization and other emerging technologies as change makers for oral cancer prevention. Ann N Y Acad Sci. 1098:167-83 (2007) PMID:17332080. Poh, C.F., Zhang, L., Anderson, D.W., Durham, J.S., Williams, P.M., Priddy, R.W., Berean, K.W., Ng, S., Tseng, O.L., MacAulay, C., and Rosin, M.P. Fluorescence visualization detection of field alterations in tumor margins of oral cancer patients. Clin Cancer Res. 12(22):6716-22 (2006) PMID:17121891 Zhang, L., Williams, M., Poh, C.F., Laronde, D., Epstein, J.B., Durham, S., Nakamura, H., Berean, K., Hovan, A., Le, N.D., Hislop, G., Priddy, R., Hay, J., Lam, W.L., and Rosin, M.P. Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome. Cancer Res. 65(17):8017-21 (2005) Rosin, M.P., Cheng, X., Poh, C., Lam, W.L., Huang, Y., Lovas, J., Berean, K., Epstein, J.B., Priddy, R., Le, N.D., and Zhang, L. Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res. 6(2):357-62 (2000) PMID:10690511. Biggar, H., Poh, C.F., Rosin, M., and Williams, P.M. Voices from the community--the voice of an oral cancer patient. J Can Dent Assoc. 2008 Apr;74(3):237-8 (2008) PMID:18387263. British Columbia Oral Cancer Prevention Program, BC Cancer Agency, College of Dental Surgeons of British Columbia. Guideline for the early detection of oral cancer in British Columbia 2008. J Can Dent Assoc. 2008 Apr;74(3):245 (2008) PMID:18401902. Link to article Guillaud, M., Zhang, L., Poh, C., Rosin, M.P., and MacAulay, C. Potential use of quantitative tissue phenotype to predict malignant risk for oral premalignant lesions. Cancer Res. 2008 May 1;68(9):3099-107 (2008) PMID:18451134. Laronde, D.M., Bottorff, J.L., Hislop, T.G., Poh, C.Y., Currie, B., Williams, P.M., and Rosin, M.P. Voices from the community--experiences from the dental office: Initiating oral cancer screening. J Can Dent Assoc. 2008 Apr;74(3):239-41 (2008) PMID:18387264. Laronde, D.M., Hislop, T.G., Elwood, J.M., and Rosin, M.P. Oral cancer: Just the facts. J Can Dent Assoc. 2008 Apr;74(3):269-72 (2008) PMID:18387267. Musa, Z., Johnston, K., Peacock, S., Rosin, M.P., and Elwood, J.M. Why should dentists screen for oral cancer? J Can Dent Assoc. 2008 Apr;74(3):243-4 (2008) PMID:18387265. Poh, C.F., Ng, S., Berean, K.W., Williams, P.M., Rosin, M.P., and Zhang, L. Biopsy and histopathologic diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc. 2008 Apr;74(3):283-8 (2008) PMID:18387269. Rosin, M.P., Poh, C.F., Elwood, J.M., Williams, P.M., Gallagher, R., MacAulay, C., Lam, W.W., Auluck, A., Zhang, L., and Hislop, T.G. New hope for an oral cancer solution: Together we can make a difference. J Can Dent Assoc. 2008 Apr;74(3):261-6 (2008) PMID:18387266. Williams, P.M., Poh, C.F., Hovan, A.J., Ng, S., and Rosin, M.P. Evaluation of a suspicious oral mucosal lesion. J Can Dent Assoc. 2008 Apr;74(3):275-80 (2008) PMID:18387268.