个人简介

M.D. (University of Toronto) M.Sc. Sci Neurlogiques (Université de Montréal) Ph.D. Physiology (University of London)

研究领域

Amyotrophic lateral sclerosis, protein kinase, neurological disease, neuron death, motoneuron

The Brain Research Lab applies neurophysiological and cell biological methods to better understand nervous system function and dysfunction. Current projects include: characterization of a cation current in neurons in health and disease, evaluation of the roles of protein and lipid kinases in a cell culture model of excitotoxicity, and determination of the role of protein kinases in an animal model of motoneuron disease.

近期论文

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Hasham MI, Pelech SL and Krieger C (1997). Glutamate-mediated activation of protein kinase C in hippocampal neurons. Neurosci. Lett. 228: 115-118. Wagey R, Krieger C, and Shaw CA (1997). Abnormal dephosphorylation effect of NMDA receptor regulation in ALS spinal cord. Neurobiology of Disease. Lanius RA, Wagey R, Sahl B, Beattie BL, Feldman H, Pelech SL, and Krieger C (1997). Protein kinase C activity and protein levels in Alzheimer's disease. Brain Res. Hasham MI, Pelech SL, Koide HB and Krieger C (1997). Activation of protein kinase C by intracellular free calcium in the motoneuron cell line NSC-19. Biochem. Biophys. Acta 1360: 177-191. Yoo, ASJ, McLarnon, JG, Xu L, Lee YB, Krieger C, and Kim SU (1996). Effects of phorbol ester on intracellular Ca2+ and membrane currents in cultured human microglia. Neurosci. Lett. 218: 37-40. Dore S, Krieger C, Kar S, and Quirion R (1996). Distribution and levels of insulin-like growth factor (IGF-1 and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients. Mol. Brain Res. 41: 128-133. Krieger C, Lanius RA, Pelech SL, and Shaw CA (1996). Amyotrophic lateral sclerosis: the involvement of intracellular CA2+ and protein kinase C. Trends in Pharmacol. Sci. 17: 114-120.