个人简介

B.S., physics (Harvey Mudd College) 1970 Ph.D., biophysics (Johns Hopkins University) 1975

研究领域

Neuroprosthetic rehabilitation of movement disorders, diaphragm pacing

Starting in the 1970's, I have pioneered the use of implanted nerve cuff electrodes, initially to investigate properties of peripheral nerves relating to transmission of sensation, proprioception, reflexes, feedback control of movement, neuromuscular plasticity and nerve survival after amputation, and more recently to provide new clinical applications aimed at restoring independence in people affected by movement disorders of central origin. My current research is expanding around clinical testing and anticipated uses of implanted neuroprosthetic devices. A new collaborative project is focused on development of a non-invasive 3D imaging method to visualize the peripheral nerves inside the limbs of people, prior to a scheduled surgery. Another new collaborative project aims to extract electrical energy from natural body movements in order to, for example, automatically recharge batteries in powered implanted or wearable devices, such as neuroprostheses.

近期论文

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Hoffer, J.A., Barú, M., Bedard, S., Calderon, E., Desmoulin, G., Dhawan, P., Jenne, G., Kerr, J., Whittaker, M. and Zwimpfer, T. Initial results with fully implanted NeurostepTM FES system for foot drop. International Functional Electrical Stimulation Soc., 10th Ann. Conf., Montreal, Canada, pp. 53-55, July 2005. Murphy, B., Krieger, C. and Hoffer, J.A. Chronically implanted epineural electrodes for repeated assessment of nerve conduction velocity and compound action potential amplitude in rodents, J. Neurosci. Methods 132:25-33, 2004. Hoffer, J.A. and K. Kallesøe, How to use nerve cuffs to stimulate, record or modulate neural activity. Chapter 5 in Neural Prostheses for Restoration of Sensory and Motor Function, K.A. Moxon and J.K. Chapin, Eds., CRC Press, pp. 139-175, 2001. Hoffer, J.A. and K. Kallesøe, Nerve cuffs for nerve repair and regeneration, Progr. Brain Res. 128:121-134, 2000. Strange, K. and Hoffer, J.A. Gait phase information provided by sensory nerve activity during walking: applicability as state controller feedback for FES . IEEE Trans. Biomed. Engineering 46:797-809, 1999. Strange, K. and Hoffer, J.A. Restoration of use of paralyzed limb muscles using sensory nerve signals for state control of FES-assisted walking. IEEE Trans. Rehab. Engineering 7:289-300, 1999. Eng, J.J. and Hoffer, J.A. Regional variability of stretch reflex amplitude in the cat medial gastrocnemius muscle during a postural task. J. Neurophysiol. 78:1150-1154, 1997. Hoffer, J.A., Stein, R.B., Haugland, M., Sinkjær, T., Durfee, W.K., Schwartz, A.B., Loeb, G.E. and Kantor, C. Neural signals for command control and feedback in functional neuromuscular stimulation: a review. J. Rehab. Res. & Dev. 33:145-157, 1996. Boorman, G.I., Hoffer, J.A., Kallesøe, K., Mah, C. and Viberg, D. A measure of peripheral nerve stimulation efficacy applicable to H-reflex studies. Can. J. Neurol. Sci. 23:264-270, 1996. Haugland, M., J.A. Hoffer and T. Sinkjaer. Skin contact force information in sensory nerve signals recorded by implanted cuff electrodes. IEEE Trans. Rehab. Engng. 2:18-28, 1994. Haugland, M. and J.A. Hoffer. Slip information provided by nerve cuff signals: application in closed-loop control of functional electrical stimulation. IEEE Trans. Rehab. Engng. 2:29-36, 1994. Hoffer, J.A., Caputi, A.A. and Pose, I.E. Activity of muscle proprioceptors in cat posture and locomotion: relation to EMG, tendon force, and the movement of fibres and aponeurotic segments. In: Muscle Afferents and Spinal Control of Movement, L. Jami, E. Pierrot-Deseilligny, D. Zytnicki, editors, IBRO Symposium Series, Pergamon Press, pp. 113-121, 1992. Hoffer, J.A. Techniques to record spinal cord, peripheral nerve and muscle activity in freely moving animals. In Neurophysiological Techniques: Applications to Neural Systems, Neuromethods 15, Eds. A.A. Boulton, G.B. Baker and C.H. Vanderwolf. Humana Press, pp. 65-145, 1990. Hoffer, J.A. Closed-loop, Implanted-sensor, Functional Electrical Stimulation System for Partial Restoration of Motor Functions: United States Patent No. 4,750,499. K. Kallesøe, J.A. Hoffer, K. Strange and I. Valenzuela Implantable Cuff having Improved Closure. United States Patent No. 5,487,756 awarded on January 30, 1996. J.A. Hoffer, Y. Chen, K. Strange and P. Christensen, Nerve Cuff having One or More Isolated Chambers. United States Patent 5,824,027, awarded on October 20, 1998. K. Kallesøe, J.A. Hoffer, K. Strange and I. Valenzuela, Implantable Cuff having Improved Closure, Canada Patent 2,139,097 awarded on Aug. 19, 2003. J.A. Hoffer, Y. Chen, K. Strange and P. Christensen, Nerve Cuff having One or More Isolated Chambers. European Patent No. 1,001,827 awarded on 14 January 2004. J.A. Hoffer, Electrical stimulation method for treating phantom limb pain and/ or for providing sensory feedback arising from a prosthetic limb. International P.C.T. Patent filed July 5, 2000. M. Barú, J.A. Hoffer, E. Calderon, G. Jenne and A. Calderon, Implantable nerve signal sensing and stimulation device and method for treating foot drop and other neurological disorders. International Patent application (PCT number PCT/IB2004/001023) filed April 2, 2004 ; published 14 October 2004. M. Barú, J.A. Hoffer, E. Calderon, G. Jenne and A. Calderon, Implantable nerve signal sensing and stimulation device and method for treating foot drop and other neurological disorders. U.S. Patent application number 20050010265 filed April 2, 2004 ; published 13 January 2005. J.A. Hoffer and G. Jenne, Implantable modular, multi channel connector system for nerve signal sensing and electrical stimulation applications. U.S. Patent application number 20050118887, filed June 3, 2004 , published June 2, 2005.