个人简介

BSc, Trent University PhD, Simon Fraser University

研究领域

Cellular, Developmental and Molecular Biology

I am interested in the physiological and genetic mechanisms underlying phenotypic variation within species, i.e., variation in whole-organism traits such as size, fecundity and behaviour. My previous work examined quantitative trait loci (QTL) affecting growth in mice, i.e., regions of the genome that contribute to continuous variation rather than major mutations that cause serious abnormalities. In this work, we identified pregnancy-associated plasma protein A2 (PAPP-A2) as the gene responsible for one particular body size QTL. My current work focuses on the roles of PAPP-A2 and related proteins in skeletal and placental development. For more information, please see my Lab Page.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Amiri, N. and Christians, J.K. 2015 PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice. Growth Hormone & IGF Research Chin, E.H., and Christians, J.K. 2015 When are sex-specific effects really sex-specific? Journal of Developmental Origins of Health and Disease 6: 438–442 Christians, J.K. and Beristain, A.G. 2015 ADAM12 and PAPP-A: candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts Cell Adhesion & Migration Christians, J.K., Bath, A.K., and Amiri, N. 2015 Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity Growth Hormone & IGF Research 25:232-239 Christians, J.K., King, A.Y., Rogowska, M.D., and Hessels, S.M. 2015 Pappa2 deletion in mice affects male but not female fertility Reproductive Biology and Endocrinology 13:109 Christians, JK; King, AY; Rogowska, MD 2015 Lack of Functional Pregnancy-Associated Plasma Protein-A2 (PAPP-A2) Does Not Affect Female Fertility or Fecundity in Mice REPROD SCI 22: 226A-226A Fronstin, R.B., Christians, J.K., and Williams T.D. 2015 Experimental reduction of hematocrit affects reproductive performance in European starlings, Sturnus vulgaris. Functional Ecology Crosley, EJ; Durland, U; Seethram, K; MacRae, S; Gruslin, A; Christians, JK 2014 First-Trimester Levels of PregnancyAssociated Plasma Protein A2 ( PAPP-A2) in the Maternal Circulation Are Elevated in Pregnancies That Subsequently Develop Preeclampsia Reprod. Sci. 21: 754-760 Erin J Crosley, Caroline E Dunk, Alexander G Beristain and Julian K Christians 2014 IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells Reproductive Biology and Endocrinology 12:123 Christians JK, de Zwaan DR, Fung SHY 2013 Pregnancy Associated Plasma Protein A2 (PAPP-A2) Affects Bone Size and Shape and Contributes to Natural Variation in Postnatal Growth in Mice. PLoS ONE 8(2): e56260 Crosley, EJ; Elliot, MG; Christians, JK; Crespi, BJ 2013 Placental invasion, preeclampsia risk and adaptive molecular evolution at the origin of the great apes: Evidence from genome-wide analyses Placenta 34: 127-132 Christians, JK; Cheema, MS; Vergara, IA; Watt, CA; Pinto, LJ; Chen, NS; Moore, MM 2011 Quantitative Trait Locus (QTL) Mapping Reveals a Role for Unstudied Genes in Aspergillus Virulence PLoS One 6 Gorman, KF; Christians, JK; Parent, J; Ahmadi, R; Weigel, D; Dreyer, C; Breden, F 2011 A major QTL controls susceptibility to spinal curvature in the curveback guppy BMC Genet. 12 Wagner, PK; Otomo, A; Christians, JK 2011 Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo) Reprod. Biol. Endocrinol. 9: - Christians, JK; Gruslin, A 2010 Altered levels of insulin-like growth factor binding protein proteases in preeclampsia and intrauterine growth restriction Prenat. Diagn. 30: 815-820 Wagner, PK; Christians, JK 2010 Altered placental expression of PAPPA2 does not affect birth weight in mice Reprod. Biol. Endocrinol. 8: - Christians, JK; Watt, CA 2009 Mononucleotide repeats represent an important source of polymorphic microsatellite markers in Aspergillus nidulans MOLECULAR ECOLOGY RESOURCES 9: 572-578 Wang, J; Qiu, Q; Haider, M; Bell, M; Gruslin, A; Christians, JK 2009 Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse JOURNAL OF ENDOCRINOLOGY 202: 337-345 Hodgson, ZG; Meddle, SL; Christians, JK; Sperry, TS; Healy, SD 2008 Influence of sex steroid hormones on spatial memory in a songbird J COMP PHYSIOL A 194: 963-969 Christians, JK; Senger, LK 2007 Fine mapping dissects pleiotropic growth quantitative trait locus into linked loci MAMMALIAN GENOME 18: 240-245