个人简介

Canada Research Chair in DNA Nanoscience, Tier I (2013-present) Member, Editorial Advisory Board, Journal of the American Chemical Society (2010-pres.) Member, Editorial Advisory Board, Bioconjugate Chemistry (2014-pres.) Member, Editorial Advisory Board, ChemBiochem (2010) Swiss Chemical Society Lectureship, 2013 E. Gordon Young Lectureship, Chemical Institute of Canada, Toronto, 2012 Strem Award for Pure or Applied Inorganic Chemistry, Canadian Society for Chemistry, 2009 William Dawson Scholar Award, McGill University (2009-2013) Fellow, Canadian Institute of Advanced Research, Nanoelectronics Program (2009-2012) NSERC Discovery Accelerator Supplement 2008-2011) Leo Yaffe Award for excellence in teaching, McGill University, Faculty of Science, 2005 Principal’s Prize for Excellence in Teaching, McGill University, Assistant Professor Category, 2003 Research Corporation (USA), Cottrell Scholar Award for excellence in research and teaching (2002) Member, NSERC CREATE Bionanomachines Member, Centre for Self-Assembled Chemical Structures (CSACS) Member, CIHR Drug Design Training Program (DDTP) Member, Pharmaqam, Quebec

研究领域

Chemical Biology Materials Chemistry Synthesis/Catalysis

Our research group studies the interaction of small organic and inorganic molecules with DNA. We use this approach to design new DNA diagnostic tools, antitumor therapeutics, and higher-order DNA structures. A second active area in our group is the synthesis of advanced materials, using small molecules and polymers as building blocks. We are specifically interested in designing biomimetic materials, which can undergo self-assembly using non-covalent interactions, such as hydrogen bonding, van der Waals interactions, or weak metal coordination. Our projects lie at the interface between synthetic chemistry, biological chemistry and materials science. They provide students with extensive training in small molecule synthesis, DNA and polymer chemistry, as well as molecular recognition and drug design.

近期论文

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Temporal Control of DNA Sequence Patterns: Designer DNA Templates for Scaffolds and Nanostructures. G. Hamblin, J. Rahbani, H. Sleiman, Nature Commun., 2015, accepted. Stepwise growth of surface-grafted DNA nanotubes visualized at the single molecule level. A. Hariri, G. D. Hamblin, H. F. Sleiman* and G. Cosa*. Nature Chem. 2015, doi:10.1038/nchem.2184 Modulation of Charge Transport Across Double-Stranded DNA by the Site-Specific Incorporation of Copper Bis-Phenanthroline Complexes. Philippe Dauphin-Ducharme , Fiora Rosati , Andrea Greschner , A. Dowine De Bruijn , Danielle Salvatore , Violeta Toader , Kai Lin Lau , Janine Mauzeroll*, and Hanadi Sleiman*. Langmuir, 2015, 31 , 1850–1854 Precision Polymers and 3D DNA Nanostructures: Emergent Assemblies from New Parameter Space. C. J. Serpell, T. G. W. Edwardson, P. Chidchob, K. M. M. Carneiro. J. Am. Chem. Soc. 2014, 136, 15767–15774 Dynamic behavior of DNA cages anchored on spherically supported lipid bilayers. Conway JW, Madwar C, Edwardson TG, McLaughlin CK, Fahkoury J, Lennox RB, Sleiman HF.J Am Chem Soc. 2014 , 136 (37), pp 12987–12997 Controlled Growth of DNA Structures From Repeating Units Using the Vernier Mechanism. Greschner AA, Bujold KE, Sleiman HF. Biomacromolecules. 2014, 15, 3002-8 Mechatronic DNA devices driven by a G-quadruplex-binding platinum ligand. Huang YC, Castor KJ, Sleiman HF, Sen D. Bioorg Med Chem. 2014 , 22, 4376-83 An efficient and modular route to sequence-defined polymers appended to DNA. Edwardson TG, Carneiro KM, Serpell CJ, Sleiman HF. Angew Chem Int Ed Engl. 2014, 53, 4567-71, “Very Important Paper”, Angewandte Front Cover Development and characterization of gene silencing DNA cages. Fakhoury JJ, McLaughlin CK, Edwardson TW, Conway JW, Sleiman HF. Biomacromolecules. 2014, 15, pp 276–282 Gold nanoparticle 3D-DNA building blocks: high purity preparation and use for modular access to nanoparticle assemblies. Lau KL, Hamblin GD, Sleiman HF. Small. 2014, 10, 660-666.