Kovalchuk, Olga - University of Lethbridge - Department of Biological Sciences

研究领域

Role of epigenetic dysregulation in carcinogenesis Epigenetic regulation of the cancer treatment responses Radiation epigenetics and role of epigenetic changes in genome stability and carcinogenesis Radiation-induced oncogenic signaling Radiation-induced DNA damage, repair and recombination

近期论文

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L. Luzhna , A. Golubov , I. Pogribny and O. Kovalchuk. Molecular mechanisms of radiation resistance in doxorubicin-resistant breast adenocarcinoma cells. DNA Repair , in revision. O. Kovalchuk , F. Zemp , J. Filkowski , J.S. Dickey, G. Jenkins-Baker , S. A. Marino, D .J. Brenner, W.M. Bonner, O.A. Sedelnikova. microRNAome changes in bystander 3D human tissue models suggest priming of apoptosis. Carcinogenesis , submitted . I. Koturbash , F. Zemp , B. Kolb and O. Kovalchuk . Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal lobe in a mouse model. Mutation Research , submitted. I.P. Pogribny, J. Filkowski , V.P. Tryndyak, S.I. Shpyleva and O. Kovalchuk . Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. International Journal of Cancer , in press. L.Luzhna and O.Kovalchuk . Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis. Biochem Biophys Res Commun, in press. J.Filkowski, Y. Ilnytsky, T. Bagnyukova, I. Koturbash, I. Pogribny and O. Kovalchuk. Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression. Carcinogenesis , in press. I. Koturbash, F. J. Zemp, I. Pogribny and O. Kovalchuk. Small molecules with big effects:The role of the microRNAome in cancer and carcinogenesis. Mutation Research , in press. I. Koturbash , J. Thomas, O. Kovalchuk , I. Kovalchuk. Heat-killed bacteria induce genome instability in the gut and in distant spleen and liver tissues. Cell Cycle 2009; 8: 1935-9 S. Ilnytskyy , I. Koturbash and O. Kovalchuk. Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner. Environmental and Molecular Mutagenesis 2009; 50:105-13. Editor's choice paper. J. Tamminga , P. Kathiria , I. Koturbash , O. Kovalchuk . DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle 2008 7:3731-3766. Editor's choice paper. Y. Ilnytskyy , F.J. Zemp , I. Koturbash , O. Kovalchuk Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun . 377:41-45. O. Kovalchuk , J. Filkowski , J. Meservy , Y.Ilnytskyy , V. Tryndyak, V. Chekhun and I. Pogribny. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Molecular Cancer Therapeutics 7: 2152-2159. I. Koturbash , K. Kutanzi, R. Rodriguez-Juarez, D. Kogosov and O. Kovalchuk . Distinct epigenetic manifestations of the in vivo radiation-induced bystander effects in male and female mice. Mutation Research 642: 28-36. I.Koturbash , F.J. Zemp , K. Kutanzi , L. Luzhna , J. Loree , B. Kolb and O. Kovalchuk. Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle 7: 1658-67. J .Tamminga, I. Koturbash , M. Baker , K. Kutanzi , P. Kathiria , I. Pogribny, R. Sutherland and O. Kovalchuk . Paternal cranial exposure induces distant bystander damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle 7: 1238-45. COVER PAGE PICTURE. C. Yauk, A. Polyzos, A. Rowan-Carroll, C.M. Somers, R.W. Godschalk, F J. Van Schooten, M.L. Berndt, I.P. Progribny, I. Koturbash , A. Williams, G.R. Douglas, O. Kovalchuk . Germline Mutations, DNA Damage and Global Hypermethylation in Mice Exposed to Particulate Air Pollution in an Urban/Industrial Location. Proceedings of the National Academy of Sciences of the USA 105:605-10 I. Koturbash , J. Loree , K. Kutanzi , C. Koganow , I. Pogribny, and O. Kovalchuk . In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage and altered cellular proliferation and apoptosis in shielded spleen. International Journal of Radiation Oncology*Biology*Physics 70: 554-62 . O. Kovalchuk . Epigenetic research sheds new light on the nature of interactions between organisms and their environment. Environmental and Molecular Mutagenesis 49:1-3. O. Kovalchuk , J.E. Baulch. Epigenetic changes and non-targeted radiation effects – is there a link? Environmental and Molecular Mutagenesis 49:16-25 C.L. Yauk, A.Polyzos, A.Rowan-Carroll, I. Kortubash , A. Williams, O. Kovalchuk . Tandem repeat mutation, global DNA methylation and regulation of DNA methyltransferases in cultured mouse embryonic stem cells chronically exposed to chemicals with different modes of action. Environmental and Molecular Mutagenesis 49:26-35.