个人简介

Postgraduate Training, Bioinformatics (Ruprecht-Karls-University, Heidelberg, Germany, 2003); Ph.D., Biochemistry (University of Witten/Herdecke, Germany, 2000); M.Sc., Chemistry (Heinrich-Heine University, Düsseldorf, Germany, 1995), B.Sc., Chemistry (Heinrich-Heine University, Düsseldorf, Germany, 1992)

研究领域

Novel translation factors, Molecular dynamics of translation, Kinetics of translation, Antibiotic (mode of action), In vitro translation, assay development

Structural and Functional dynamics of protein biosynthesis; the study of protein biosynthesis using a purified reconstituted E. coli translation system; kinetics and structural dynamics of elongation factors; functional roles of ribosomal proteins.

近期论文

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Dahl L. D., Wieden H.-J., Rodnina M. V., Knudsen C. R. (2006) The importance of P-loop and domain movements in EF-Tu for guanine nucleotide exchange.J. Biol. Chem. 281,21139-21146. Buskiewicz I., Peske F., Wieden H.-J., Gryczynski I., Rodnina M. V., Wintermeyer W. (2005) Conformations of the Signal Recognition Particle Protein Ffh from Escherichia coli as Determined by FRET. J Mol Biol. 351,417-430. Rodnina M.V., Gromadski K.B., Kothe U., Wieden H.-J. (2005) Recognition and selection of tRNA in translation. FEBS Lett. 579,938-942. Kothe U., Wieden H.-J., Mohr D., Rodnina M.V. (2004) Interaction of helix D of elongation factor Tu with helices 4 and 5 of protein L7/12 on the ribosome. J Mol Biol. 336(5):1011-1021. Daviter T, Wieden, H.-J., and Rodnina M. V. (2003) Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome. J. Mol. Biol. 32,689-699. Gu, S.-Q., Peske, F., Wieden, H.-J., Rodnina, M.V., and Wintermeyer, W. (2003) The signal recognition particle binds to protein L23 at the peptide exit of the E. coli ribosome. RNA 9, 566- 573. Juranek, S., Wieden, H.-J, and Lipps, H. J. (2003) De novo cytosine methylation in the differentiating macronucleus of the stichotrichous ciliate Stylonychia lemnae. Nuc. Acids Res. 31, 1387-1391. Stark, H., Rodnina, M.V., Wieden, H.-J., Zemlin, F., Wintermeyer, W., and van Heel, M. (2002) Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon recognition complex. Nat. Struct. Biol. 9, 849-854. Schirmer, J., Wieden, H.-J., Rodnina, M. V., and Aktories, K. (2002) Inactivation of the elongation factor Tu by mosquitocidal toxin catalyzed mono-ADP-ribosylation. Appl. Environ. Microbiol. 68, 4894-4899. Wieden, H.-J., Gromadski, K.B., Rodnin, D. N., and Rodnina, M. V. (2002) Mechanism of EF-Ts- catalzed nucleotide exchange in EF-Tu: Contribution of contacts at the guanine base. J. Biol. Chem. 277, 6032-6036. Gromadski, K. B., Wieden, H.-J., and Rodnina, M. V. (2002) Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu. Biochemistry 41, 162-169. Knudsen, C., Wieden, H.-J., and Rodnina, M. V. (2001) Importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome. J. Biol. Chem. 276, 22183-22190. Wieden, H.-J., Wintermeyer, W. and Rodnina, M. V. (2001) A common structural motif in elongation factor Ts and ribosomal protein L7/12 may be involved in the interaction with elongation factor Tu. J. Mol. Evol. 52, 129-136. Stark, H., Rodnina, M.V., Wieden, H.-J., van Heel, M., and Wintermeyer, W. (2000) Large-scale movement of elongation factor G and extensive conformational changes of the ribosome during translocation. Cell 100, 301-309. Rodnina, M. V., Stark, H., Savelsbergh, A., Wieden, H.-J., Mohr, D., Matassova, N. B., Peske, F., Daviter, T., Gualerzi, C. O., and Wintermeyer, W. (2000) GTPase mechanisms and functions of translation factors on the ribosome. Biol. Chem. 381, 377-387.