个人简介

PhD : University of Nottingham, UK 2007 MSc : Sardar Patel University, India 2002 BSc : Sardar Patel University, India 2000

研究领域

Cell Biology, Biochemistry, Biophysics

Host Protein - Viral RNA Interactions Viruses require host machinery to replicate. Although our immune system has several layers of defense mechanisms, often viral infection results in hijacking host cell machinery. A variety of host proteins recognize viral RNA molecules as a part of an innate immune system. On the other hand, often viral RNA recognize and employ host proteins to facilitate their replication and propagation. The main focus of our group is to understand, in fine detail, how viral components recognize DEAD-box helicases (e.g. DDX1, DDX3 and DDX5) and develop novel inhibitors that interfere with host-viral component interactions, resulting in inhibition of viral replication using a multidisciplinary approach. Role of Focal Adhesion Proteins in Diseases Our laboratory is also interested in investigating the role Zyxin and WTIP proteins that are primarily located at the focal adhesions but also able to travel to the nucleus. Zyxin is linked with cancer whereas WTIP plays a crucial role in maintaining normal activity of podocytes in kidney and acts as a transcription regulator. Our goal is to study how they mediate the transfer of signals from outside cell to inside, to understand their nuclear functions and to investigate their role in diseases such as cancer.

近期论文

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Reuten R.*, Patel, T. R.*, McDougall, M.*, Rama, N., Nikodemus, D., Gibert, B., Delcros, J., Prein, C., Meier, M., Metzger, S., Zhou, Z., Kaltenberg, J., McKee, K. K., Bald, T., Tüting, T., Zigrino, P., Djonov, V., Bloch, W, Clausen-Schaumann, H., Poschl, E., Yurchenco, P. D., Ehrba, M., Mehlen, P., Stetefeld, J. and Koch, M. Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes. Nature Communications (in press) Krahn, N., Spearman, M, Meier, M., Spearman, M., Dorion-Thibaudeau, J., McDougall, M., Patel, T. R., De Crescenzo, G., Durocher, Y., Stetefeld, J. and Butler, M. Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity. European Journal of Pharmaceutical Sciences (2016) 96, 428-439 Stetefeld, J., McKenna, S. A. and Patel, T. R.# Dynamic light scattering: A practical guide and applications in biomedical sciences. Biophysical Reviews (2016), 1-19 Gillis, R. B., Adams, G. G., Besong, T. M., Machová, E., Ebringerová, A., Rowe, A. J., Harding, S. E. and Patel, T. R.# Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans. European Biophysics Journal (2016), 1-11 Sarhan, A. R., Patel, T. R., Tomlinson, M. G., Hellberg, C., Heath, J. K., Cunningham, D. L. and Hotchin N. A. LAR protein tyrosine phosphatase regulates focal adhesions through CDK1. Journal of Cell Sciences (2016) 29, 175-185 Sarhan, A. R., Patel, T. R., Creese, A. J., Tomlinson, M. G., Hellberg, C., Heath, J. K., Hotchin N. A. and Cunningham, D. L. Regulation of platelet derived growth factor signalling by Leukocyte common antigen-related (LAR) protein tyrosine phosphatase: a quantitative phosphoproteomics study. Molecular and Cellular Proteomics (2016) 15, 1823-1836 Reuten, R., Nikodemus, D., Oliveria, M. B., Patel, T. R., Brachvogel, B., Breloy, I., Stetefeld, J. and Koch, M. Maltose-binding protein (MBP), a secretion-enhancing tag for mammalian protein expression systems. PLoS One (2016) 1, e0152386 Grandin, M., Meier, M., Delcros, J, G., Nikodemus, D., Reuten, R., Patel, T. R., Goldschneider, D., Orriss, G., Krahn, N., Dean, Y., Neves, D., Bernet, A., Depil, S., Schneiders, F., Poole, K., Mehlen, P., Koch, M. and Stetefeld, J. Structural decoding of the Netrin-1/UNC5 interaction and its therapeutical implications in cancers. Cancer Cell (2016) 29, 175-185 Patel, T. R.,# Nikodemus, D., Reuten, R., Besong, T. M., Meier, M., Winzor, D. J., Koch, M. and Stetefeld, J. Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction. Matrix Biology (2016) 49, 93-105 Patel, T. R.#, Winzor, D. J. and Scott, D. J. Analytical ultracentrifugation: A versatile tool for the characterisation of macromolecular complexes in solution. Methods (2016) 95, 55-61