Thompson, Roger - University of Calgary - Department of Cell Biology and Anatomy

个人简介

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)

研究领域

Dr. Thompson's lab is focussed on understanding the mechanisms of neuronal death during neurodegenerative diseases and the fundamentals of synaptic plasticity. They currently focus on a novel mechanism of signalling by the NMDA receptor, its so-called metabotropic role. Additionally, the lab uses state of the art electrophysiology, imaging, and molecular biology techniques to elucidate the diverse neuronal and synaptic roles played by an ion channel, pannexin-1 in cell death and plasticity.

近期论文

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Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity.Weilinger NL, Lohman AW, Rakai BD, Ma EM, Bialecki J, Maslieieva V, Rilea T, Bandet MV, Ikuta NT, Scott L, Colicos MA, Teskey GC,Winship IR, Thompson RJ.Nat Neurosci. 2016 Feb 8. doi: 10.1038/nn.4236. [Epub ahead of print] A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus.Maslieieva V, Thompson RJ.Channels (Austin). 2014;8(2):131-41. doi: 10.4161/chan.27653. Epub 2014 Jan 13. Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases.Weilinger NL, Tang PL, Thompson RJ.J Neurosci. 2012 Sep 5;32(36):12579-88. doi: 10.1523/JNEUROSCI.1267-12.2012. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.Thompson RJ, Jackson MF, Olah ME, Rungta RL, Hines DJ, Beazely MA, MacDonald JF, MacVicar BA.Science. 2008 Dec 5;322(5907):1555-9. doi: 10.1126/science.1165209. Ischemia opens neuronal gap junction hemichannels.Thompson RJ, Zhou N, MacVicar BA. Science. 2006 May 12;312(5775):924-7.