Reynolds, John - University of Calgary - Department of Cell Biology and Anatomy

个人简介

Dr. John Reynolds was appointed to his role of Associate Vice-President (Research) in August 2013. Reynolds received his PhD in Immunology at the Australian National University, Canberra, in 1976. He did postdoctoral work at the Institute of Cancer Research in London, UK and in 1979 he became a member of the Basel Institute for Immunology, Switzerland. In 1983 Reynolds joined the University of Calgary as an Assistant Professor in Physiology and Biophysics. During his tenure, Reynolds has served as Head of the Department of Cell Biology and Anatomy (1999-2004) and Associate Dean Basic Research (2005-2013) in the Faculty of Medicine.

研究领域

Reynolds’ research is focused on the development and selection of B-lymphocytes, including mechanisms that allow the survival of those B lymphocytes that recognize foreign antigens and the destruction of B lymphocytes that recognize self-antigens. He has been active in the Canadian Society for Immunology (CSI) since 1983, serving as President and organizer of several annual conferences. His contributions to the CSI were recognized in 2008 by the creation of the John D Reynolds Award, which is an annual award for outstanding contributions to the CSI. He has also served as Chair of the Gastrointestinal Research Group (1989-91) and the Immunology Research Group (1992-1996), and Director of the Flow Cytometry Lab (2002-2014). Reynolds has also been a member of the boards of Research Canada since 2012, plus Innovate Calgary and the ASTech Foundation since 2013. He is Executive Director of Research Services, co-chair of the USER taskforce and CSIG and a member of many committees at the University of Calgary.

近期论文

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Diffusion Tensor Imaging of White Matter in Children Born from Preeclamptic Gestations.Figueiró-Filho EA, Croy BA, Reynolds JN, Dang F, Piro D, Rätsep MT, Forkert ND, Paolozza A, Smith GN, Stroman PW.AJNR Am J Neuroradiol. 2017 Jan 26. doi: 10.3174/ajnr.A5064. [Epub ahead of print] Brain Structural and Vascular Anatomy Is Altered in Offspring of Pre-Eclamptic Pregnancies: A Pilot Study.Rätsep MT, Paolozza A, Hickman AF, Maser B, Kay VR, Mohammad S, Pudwell J, Smith GN, Brien D, Stroman PW, Adams MA, Reynolds JN, Croy BA, Forkert ND.AJNR Am J Neuroradiol. 2016 May;37(5):939-45. doi: 10.3174/ajnr.A4640. When should chest compressions be paused to analyze the cardiac rhythm? A systematic review and meta-analysis.Reynolds JC, Raffay V, Lang E, Morley PT, Nation K.Resuscitation. 2015 Dec;97:38-47. doi: 10.1016/j.resuscitation.2015.09.385. Review. Chronic ethanol exposure increases the non-dominant glucocorticoid, corticosterone, in the near-term pregnant guinea pig.Hewitt AJ, Dobson CC, Brien JF, Wynne-Edwards KE, Reynolds JN.Alcohol. 2014 Aug;48(5):477-81. doi: 10.1016/j.alcohol.2014.06.005. The sheep and cattle Peyer's patch as a site of B-cell development.Yasuda M, Jenne CN, Kennedy LJ, Reynolds JD.Vet Res. 2006 May-Jun;37(3):401-15.Review. Prion diseases and the gastrointestinal tract.Davies GA, Bryant AR, Reynolds JD, Jirik FR, Sharkey KA.Can J Gastroenterol. 2006 Jan;20(1):18-24. Review. Antibody repertoire development in the sheep.Jenne CN, Kennedy LJ, Reynolds JD.Dev Comp Immunol. 2006;30(1-2):165-74. Review. The role of macrophages in the removal of apoptotic B-cells in the sheep ileal Peyer's patch.Bhogal HS, Kennedy LJ, Babic K, Reynolds JD.Dev Comp Immunol. 2004 Jun;28(7-8):843-53. A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation.Jenne CN, Kennedy LJ, McCullagh P, Reynolds JD.J Immunol. 2003 Apr 1;170(7):3739-50. The genesis, tutelage and exodus of B cells in the ileal Peyer's patch of sheep.Reynolds J.Int Rev Immunol. 1997;15(3-4):265-99. B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain.Maybaum TA, Reynolds JD.J Immunol. 1996 Aug 15;157(4):1474-84. Membrane fluidity increases during apoptosis of sheep ileal Peyer's patch B cells.Jourd'heuil D, Aspinall A, Reynolds JD, Meddings JB.Can J Physiol Pharmacol. 1996 Jun;74(6):706-11. Apoptosis of ileal Peyer's patch B cells is increased by glucocorticoids or anti-immunoglobulin antibodies.Motyka B, Bhogal HS, Reynolds JD.Eur J Immunol. 1995 Jul;25(7):1865-71. Rescue of ileal Peyer's patch B cells from apoptosis is associated with the induction of Bcl-2 expression.Motyka B, Reynolds JD.Immunology. 1995 Mar;84(3):383-7. Agents that activate protein kinase C rescue sheep ileal Peyer's patch B cells from apoptosis.Motyka B, Griebel PJ, Reynolds JD.Eur J Immunol. 1993 Jun;23(6):1314-21. Characterization of B-cell phenotypic changes during ileal and jejunal Peyer's patch development in sheep.Griebel PJ, Kennedy L, Graham T, Davis WC, Reynolds JD.Immunology. 1992 Dec;77(4):564-70. T-cell receptor-gamma delta association with lymphocyte populations in sheep intestinal mucosa.Gyorffy EJ, Glogauer M, Kennedy L, Reynolds JD.Immunology. 1992 Sep;77(1):25-30. An analysis of the growth and differentiation of B cells isolated from follicles of the ileal Peyer's patch of sheep.Griebel PJ, Davis WC, Reynolds JD.Immunology. 1992 Apr;75(4):601-7. Capsaicin effects on non-neuronal plasma membranes.Meddings JB, Hogaboam CM, Tran K, Reynolds JD, Wallace JL.Biochim Biophys Acta. 1991 Nov 18;1070(1):43-50. Negative signaling by surface IgM on B cells isolated from ileal Peyer's patch follicles of sheep.Griebel PJ, Davis WC, Reynolds JD.Eur J Immunol. 1991 Sep;21(9):2281-4.