个人简介

Maitrise (University of Nancy, France, 1994) Ph.D. (University of Nancy, France, 1998) Postdoctoral fellow (University of Montreal, 1998-2000) Charge de recherche (Research senior, CNRS, Nancy, 2001-2003)

研究领域

Chemical Biology Synthesis/Catalysis

Whether it deals with life sciences, materials, or other areas of high impact, molecular discovery remains a long and tedious process. In practice, developing a new anticancer drug, a new catalysts for asymmetric transformation or a new methodology for green polysaccharides synthesis currently takes years. Our approach is to integrate advanced organic synthesis and computer science to significantly improve the molecular discovery rate. In this context, the Moitessier group is active in the following areas: Organic Chemistry, medicinal chemistry and asymmetric synthesis: Development of organic synthesis methodologies for the preparation of constrained proline mimetics. Application to the preparation of asymmetric catalysts and anticancer drugs. Directing Protecting Groups: a novel concept for green and regioselective transformations of amines and alcohols. Computer science: Development of predictive software such as a docking program FITTED (predicting drug binding mode and potency), IMPACTS (predicting the sites of metabolism of drugs by liver enzymes P450s), and the complete drug discivery platform FORECASTER. Development of ACE (a virtual screening techniques in the field of asymmetric catalyst design) Integrated organic/computational chemistry Computer-aided design and synthesis of biologically relevant compounds. Computer-aided design and synthesis of novel asymmetric catalysts.

近期论文

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Therrien E., Weill N., Tomberg A., Corbeil C.R., Lee D., Moitessier N. Docking Ligands into Flexible and Solvated Macromolecules. 7. Impact of Protein Flexibility and Water Molecules on Docking-based Virtual Screening Accuracy. "Journal of Chemical Information and Modeling" (2014), 54 (11), 3198–3210 Pottel J., Therrien E., Gleason J.L., Moitessier N. Docking Ligands into Flexible and Solvated Macromolecules. 6. Development and Application to the Docking of HDACs and other Zinc Metalloenzymes Inhibitors "Journal of Chemical Information and Modeling" (2014), 54, 1, 254-265 Castor, K. J., Liu, Z., Fakhoury, J., Hancock, M. A., Mittermaier, A., Moitessier, N. and Sleiman, H. F. A Platinum(II) Phenylphenanthroimidazole with an Extended Side-Chain Exhibits Slow Dissociation from a c-Kit G-Quadruplex Motif. "Chemistry - A European Journal" (2013), 52, 19, 17836–17845 Campagna-Slater V., Therrien E., Weill N., Moitessier N. Methods for Docking Small Molecules to Macromolecules: A User's Perspective. 2. Applications. "Current Pharmaceutical Design" (2013), 1873-4286 Weill N., Therrien E., Campagna-Slater V., Moitessier N. Methods for Docking Small Molecules to Macromolecules: A User's Perspective. 1. The Theory. "Current Pharmaceutical Design" (2013) Bezanson, M., Pottel, J., Bilbeisi, R., Toumieux, S., Cueto, M., Moitessier, N., Stereo- and Regioselective Synthesis of Polysubstituted Chiral 1,4-Oxazepanes "J. Org. Chem." (2013), 78, 3, 872–885 Campagna-Slater V., Pottel J., Therrien E., Cantin L.-D., Moitessier N. Development of a computational tool to rival experts in the prediction of sites of metabolism of xenobiotics by P450s "Journal of Chemical Information and Modeling" (2012), 52, 9, 2471-2483 De Cesco S., Deslandes S., Therrien E., Levan D., Cueto M., Schmidt R., Cantin L.-D., Mittermaier A., Juillerat-Jeanneret L., Moitessier N. Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells "Journal of Medicinal Chemistry" (2012), 55, 14, 6306-6315 Therrien E., Englebienne P., Arrowsmith A.G., Mendoza-Sanchez R., Corbeil C.R., Weill N., Campagna-Slater V., Moitessier N. Integrating medicinal chemistry, organic/combinatorial chemistry, and computational chemistry for the discovery of selective estrogen receptor modulatorswith FORECASTER, a novel platform for drug discovery "Journal of Chemical Information and Modeling" (2012), 52, 1, 210-224 Castor K.J., Mancini J., Fakhoury J., Weill N., Kieltyka R., Englebienne P., Avakyan N., Mittermaier A., Autexier C., Moitessier N., Sleiman H.F. Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes "ChemMedChem" (2012), 7, 1, 85-94 Lawandi J., Rocheleau S., Moitessier N. Directing/protecting groups mediate highly regioselective glycosylation of monoprotected acceptors "Tetrahedron" (2011), 67, 43, 8411-8420 Weill N., Corbeil C.R., De Schutter J.W., Moitessier N. Toward a computational tool predicting the stereochemical outcome of asymmetric reactions: Development of the molecular mechanics-based program ACE and application to asymmetric epoxidation reactions "Journal of Computational Chemistry" (2011), 32, 13, 2878-2889 Lamblin M., Spingarn R., Wang T.-T., Burger M.C., Dabbas B., Moitessier N., White J.H., Gleason J.L. An o -aminoanilide analogue of 1α,25-dihydroxyvitamin D-3 functions as a strong vitamin D receptor antagonist "Journal of Medicinal Chemistry" (2010), 53, 20, 7461-7465 Huot M., Moitessier N. Expedient synthesis of novel bicyclic peptidomimetic scaffolds "Tetrahedron Letters" (2010), 51, 21, 2820-2823 Lawandi J., Gerber-Lemaire S., Juillerat-Jeanneret L., Moitessier N. Inhibitors of prolyl oligopeptidases for the therapy of human diseases: Defining diseases and inhibitors "Journal of Medicinal Chemistry" (2010), 53, 9, 3423-3438 Corbeil C.R., Moitessier N. Theory and application of medium to high throughput prediction method techniques for asymmetric catalyst design "Journal of Molecular Catalysis A: Chemical" (2010), 324, 1-2, 146-155 Kieltyka R., Englebienne P., Moitessier N., Sleiman H. Quantifying interactions between G-quadruplex DNA and transition-metal complexes. "Methods in molecular biology (Clifton (2010), N.J.)", 608, -223 Corbeil C.R., Therrien E., Moitessier N. Modeling reality for optimal docking of small molecules to biological targets "Current Computer-Aided Drug Design" (2009), 5, 4, 241-263 Englebienne P., Moitessier N. Docking ligands into flexible and solvated macromolecules. 5. Force-field-based prediction of binding affinities of ligands to proteins "Journal of Chemical Information and Modeling" (2009), 49, 11, 2564-2571 Lawandi J., Toumieux S., Seyer V., Campbell P., Thielges S., Juillerat-Jeanneret L., Moitessier N. Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors "Journal of Medicinal Chemistry" (2009), 52, 21, 6672-6684