WISSMANN, ANDREAS - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Andreas Wissmann, Ph.D. Pharmaceutical drug discovery based on the use of model animals; technologies related to medical education. Andreas completed his PhD studies in Erlangen, Germany where his work laid the basis for the Tet-on and Tet-off gene regulation system that has been widely used for inducible eukaryotic gene expression studies. Following a brief stint in Boston, Andreas moved to the University of Calgary for further post-doctoral studies. During his time, Andreas identified the first genetic mutations in Rho-kinase and mapped out the first genetic pathways in which this gene plays a role. Rho-kinase has subsequently been shown to be potentially involved in multiple human pathologies, such as brain injury, hypertension, spinal cord injuries and cancer. In 1998 Andreas moved to San Francisco and joined Axys Pharmaceuticals (which later became Celera Genomics). During his time at Axys Andreas developed a chemical high-throughput whole animal-based screen for compounds that inhibit Rho-kinase pathway activity. These screens led to the identification of multiple new chemical entities (NCE) which were subsequently shown to also have effects in mammalian cells consistent with reduced Rho-kinase pathway activity. In 2001 he co-founded NemaGain Research LLC a company based in Madison, Wisconsin focused on using whole animal models of human disease for pharmaceutical drug discovery. In 2003 Andreas co-founded Calgary-based NemaRx Pharmaceuticals with a similar technology platform. The company worked mostly in the area of identifying chemical enhancers and suppressors of antidepressants (shared mechanisms between SSRIs and tricyclics) coupled with subsequent genetic analysis of such compounds. These studies identified antidepressant-mediated increases in cellular resilience (stress-resistance), possibly mediated through mitochondria, as one of the shared mechanisms of action between SSRIs & tricyclics. Similar studies were conducted for whole animal-based models of excessive growth factor signaling (with a focus on possible new cancer therapeutics). In 2010 Andreas joined a laboratory instrumentation start-up company (Nanalysis Corp; benchtop NMR) and in 2012 he co-founded The Lindsay Project Corp., a medical anatomy & physiology educational software company based on technology that has been developed at the University of Calgary.

近期论文

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Optogenetic stimulation of accumbens shell or shell projections to lateral hypothalamus produce differential effects on the motivation for cocaine.Larson EB, Wissman AM, Loriaux AL, Kourrich S, Self DW.J Neurosci. 2015 Feb 25;35(8):3537-43. doi: 10.1523/JNEUROSCI.1524-14.2015. Seasonal changes in patterns of gene expression in avian song control brain regions.Thompson CK, Meitzen J, Replogle K, Drnevich J, Lent KL, Wissman AM, Farin FM, Bammler TK, Beyer RP, Clayton DF, Perkel DJ, Brenowitz EA.PLoS One. 2012;7(4):e35119. doi: 10.1371/journal.pone.0035119. Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity.Wissman AM, May RM, Woolley CS.Brain Struct Funct. 2012 Apr;217(2):181-90. doi: 10.1007/s00429-011-0353-6. Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats.Sato SM, Wissman AM, McCollum AF, Woolley CS.PLoS One. 2011;6(7):e21783. doi: 10.1371/journal.pone.0021783. Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens.Wissman AM, McCollum AF, Huang GZ, Nikrodhanond AA, Woolley CS.Neuropharmacology. 2011 Jul-Aug;61(1-2):217-27. doi: 10.1016/j.neuropharm.2011.04.002. The role of neurotrophins in the seasonal-like growth of the avian song control system.Wissman AM, Brenowitz EA.J Neurosci. 2009 May 20;29(20):6461-71. doi: 10.1523/JNEUROSCI.0638-09.2009. Seasonal regulation of NMDA receptor NR2B mRNA in the adult canary song system.Singh TD, Heinrich JE, Wissman AM, Brenowitz EA, Nordeen EJ, Nordeen KW.J Neurobiol. 2003 Mar;54(4):593-603. Dehydroepiandrosterone (DHEA) increases territorial song and the size of an associated brain region in a male songbird.Soma KK, Wissman AM, Brenowitz EA, Wingfield JC.Horm Behav. 2002 Mar;41(2):203-12. Hair cell regeneration and recovery of auditory thresholds following aminoglycoside ototoxicity in Bengalese finches.Woolley SM, Wissman AM, Rubel EW.Hear Res. 2001 Mar;153(1-2):181-95.