研究领域
Dr. Sensen’s research interests are mainly in the areas of Bioinformatics and Genome Research. Over the years, he has been involved in several large-scale programs, which were funded mainly by Genome Canada, Genome Prairie/Alberta, the Alberta Livestock and Meat Agency and others.
Currently he is involved in several research programs in the area of renewable resources, where his laboratory is analyzing DNA sequences from high-throughput experiments to characterize the transcriptome of fungi, as well as plants. He is also involved in Metagenomics studies of the Albertan Oilsands.
In addition, the Sensen laboratory is studying the use of circulating nucleic acids (CNA), which were isolated from blood samples as markers for chronic diseases. Initially, the laboratory used this method to characterize animals infected with Chronic Wasting Disease (CWD). Now, the method is applied to other chronic diseases, including Bovine Spongiform Encephalopathy (BSE).
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Schneider- Poetsch, H.A.W., Sensen, C., Hanelt, S. (1991) Are Bacterial Sensory Systems Models for Phytochrome Action? Hydrophobic Cluster Analysis of the Phytochrome Module Related to Bacterial Transmitter Modules. Z. Naturforsch. 46c:750-758
Sensen, C. W., Heimann, K., Melkonian, M. (1993) The production of clonal and axenic cultures of microalgae using fluorescence activated cell sorting (FACS). Eur J Phycol 28:93-97 (online)
Wiemann, S., Voss, H., Schwager, C., Rupp, T., Stegemann, J., Zimmermann, J., Grothues, D., Sensen, C., Erfle, H., Hewitt, N., Banrevi, A., Ansorge, W. (1993) Sequencing and Analysis of 51.6 kilobases on the Left Arm of Chromosome XI from Saccharomyces cerevisiae Reveals 23 Open Reading Frames Including the FAS1 Gene. Yeast 9:1343-1348
Voss, H., Wiemann, S. Grothues, D., Sensen, C., Zimmermann, J., Schwager, C., Stegemann, J., Erfle, H., Rupp, T., Ansorge, W. (1993) Automated Low- Redundancy Large- Scale DNA Sequencing by Primer Walking. Biotechniques 15:714-721
Grothues D., Voss H., Stegemann J., Wiemann S., Sensen C., Zimmermann J., Schwager C., Erfle H., Rupp T., Ansorge W. (1993) Separation of up to 1000 bases on a modified A.L.F. DNA sequencer. Nucl. Acids Res. 21:6042-6044 (online)
Dujon B., ..., Sensen C., ... et al. (1994) Complete DNA sequence of yeast chromosome XI. Nature 396:371-378
Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W. (1995) Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX. Yeast 11:61-78
Kranz H.D., Miks D., Siegler M.L., Capesius I., Sensen C.W., Huss V.A.R. (1995) The Origin of Land Plants: Phylogenetic Relationships between Charophytes, Bryophytes, and a Club Moss Inferred from Complete Small Subunit Ribosomal RNA Gene Sequences. J. Mol. Evol. 41:74-84
Gaasterland T., Sensen C. W. (1996) MAGPIE: Using multiple tools for automated genome interpretation. Trends in Genetics 12:76-78
Keeling P.J., Klenk H.P., Singh R.K., Feeley O., Schleper C., Zillig W., Doolittle W.F., Sensen C.W. (1996) Complete Nucleotide Sequence of the Sulfolobus islandicus Multicopy Plasmid pRN1. Plasmid 35:141-144
Charlebois R.L., Gaasterland T., Ragan M.A., Doolittle W.F., Sensen C.W. (1996) The Sulfolobus solfataricus P2 genome project. FEBS Letters 389:88-91
Sensen C.W., Klenk H.P., Singh R. K., Allard G., Chan C.C.-Y., Liu Q., Penny S., Young F., Schenk M., Gaasterland T., Doolittle W.F., Ragan M.A., Charlebois R.L. (1996) Organizational characteristics and information content of an archaeal genome: 156 kbp of contiguous sequence from Sulfolobus solfataricus P2. Mol. Microbiol. 22:175-191
Gaasterland T., Sensen C.W. (1996) Fully automated genome analysis that reflects user needs and preferences - A detailed introduction to the MAGPIE system architecture -. Biochimie 78:302-310
Ragan M.A., Logsdon J.M. Jr., Sensen C.W., Charlebois R.L., Doolittle W.F. (1996) An archaeal homolog of pelota, a meiotic cell division protein in eukaryotes. FEMS Microbiology Letters 144:151- 155
Charlebois R.L., Sensen C.W., Doolittle W.F., Brown J.R. (1997) Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2. J. Bacteriol. 179:4429-4432 (online)
Patwary M.U., Sensen C.W., MacKay R.M., van der Meer J.P. (1998) Nucleotide sequences of small-subunit and internal transcribed spacer regions of nuclear rRNA genes support the autonomy of some genera of the Gelidiales (Rhodophyta). J. Phycol 34:299-305
Sensen C.W., Charlebois R.L., Chow C., Clausen I.G., Curtis B., Doolittle W.F., Duguet M., Erauso G., Gaasterland T., Garrett R.A., Gordon P., Heikamp de Jong I., Jeffries A.C., Kozera C., Medina N., De Moors A., van der Oost J., Phan H., Ragan M.A., Schenk M.E., She Q., Singh R.K., Tolstrup N. (1998) Completing the sequence of the Sulfolobus solfataricus P2 genome. Extremophiles 2:305-312
Keeling P.J., Klenk H.-P., Singh R.K., Schenk M.E., Sensen C.W., Zillig W., Doolittle W.F. (1998) Sulfolobus islandicus plasmids pRN1 and pRN2 share distant but common evolutionary ancestry. Extremophiles 2:391-393
Charlebois R.L., She Q., Sprott D.B., Sensen C.W., Garrett R.A. (1998) Sulfolobus genome: from genomics to biology. Curr. Opin. Microbiol. 1:584-588
Romine M.F., Stilwell, L., Wong K.-K., Thurston S.J., Sisk E.C., Sensen C., Gaasterland T., Frederickson J.K., Saffer. J.D. (1999) Complete Sequence of a 184-Kilobase Catabolic Plasmid from Sphingomonas aromaticivorans Strain F199. J. Bacteriol. 181:1585-1602 (online)
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