个人简介
Ph.D. (Doctor of Philosophy)
研究领域
I am a biochemist with expertise in finding protein-protein interactions using proteomics approach. I also gained electrophysiological training while working at the Cystic Fibrosis Center at the University of North Carolina-Chapel Hill. My primary research interest is;
1. Studying the ubiquitin conjugation of voltage-gated calcium channels such as L-type and T-type channels.
2. Identifying protein partners that regulate this post-translational modification, particularly ubiquitin ligases and proteases.
3. Understanding how neuro-inflammatory interactions lead to neuropathic pain, the output of these studies may result in novel specific therapeutic approaches.
近期论文
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A cell permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain. Garcia-Caballero A, Gadotti VM and Zamponi GW. (in press in Mol Pain)
The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity.
García-Caballero A, Gadotti VM, Stemkowski P, Weiss N, Souza IA, Hodgkinson V, Bladen C, Chen L, Hamid J, Pizzoccaro A, Deage M, François A, Bourinet E, Zamponi GW. Neuron. 2014 Sep 3;83(5):1144-58
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain. Gadotti VM, Caballero AG, Berger ND, Gladding CM, Chen L, Pfeifer TA, Zamponi GW. Mol Pain. 2015 Mar 14;11:12
García-Caballero A, Gadotti VM, Weiss N, Bladen C, Chen L, Souza I,Pizzoccaro A, Deage M, Bourinet E, Zamponi GW, The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 T-type calcium channel activity. 2013 (In Press; Neuron)
Kota P, García-Caballero A, Dang H, Gentzsch M, Stutts MJ, Dokholyan NV. Energetic and structural basis for activation of the epithelial sodium channel by matriptase. Biochemistry. 2012 Apr 3
Watt GB, Ismail NAS, García-Caballero A, Stephen C. Land SC and Wilson SM. Glucocorticoid-induced activation of Epithelial Na+ channels in human airway epithelial cells: effects of inhibiting the kinases PI3K, TORC2 and SGK1. Br J Pharmacol. 2012 Jan 17. 1476-5381.
Altier C, García-Caballero A, Simms B, You H, Chen L, Walcher J, Tedford HW, Hermosilla T and Zamponi GW. The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nature Neuroscience. 2011, 14, 173–180
García-Caballero A, Ishmael SS, Dang Y, Gillie D, Bond SJ, Milgram LS and Stutts JM. Activation of the Epithelial Sodium Channel by the metalloprotease Meprin b subunit. Channels. 2011 Jan 26;5(1)
Rollins MB, García-Caballero A, Stutts JM and Tarran R. SPLUNC1 Expression Reduces Surface Levels of the Epithelial Sodium Channel (ENaC) in Xenopus Laevis Oocytes. Channels. 2010 Jul; 4;4(4).
García-Caballero A, Rasmussen J, Gaillard E, Watson M, Olsen J, Donaldson HS, Stutts JM and Tarran R. SPLUNC1 Regulates Airway Surface Liquid Volume by Protecting ENaC from Proteolytic Cleavage. Proc Natl Acad Sci U S A. 2009 June 18.
García-Caballero A, Dang Y, Hong H and Stutts JM. ENaC proteolytic regulation by channel activating serine protease 2 (CAP2). J. Gen. Physiol. 2008 Nov;132(5):521-35.
Harris, M, García-Caballero A, Stutts JM, Firsov D and Rossier CB. Preferential assembly of α, β and g-ENaC subunits in Xenopus oocyte: role of furin mediated endogenous proteolysis. J Biol Chem. 2008 Mar 21;283(12):7455-63.
Olivares-Reyes JA, Shah BH, Hernandez-Aranda J, García-Caballero A, Farshori MP, Garcia-Sáinz JA and Catt KJ. Agonist-induced interactions between Angiotensin AT1 and Epidermal Growth Factor Receptors. Molecular Pharmacology. 2005, 68(2):356-64
Avendano-Vazquez SE, García-Caballero A and Garcia- Sáinz JA. Phosphorylation and desensitization of the Lysophosphatidic acid receptor LPA 1. Biochemical Journal 2005, 385 (Pt 3): 677-684.
García-Caballero A, Olivares-Reyes JA, Catt KJ and Garcia-Sáinz JA. Angiotensin AT1 receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase C and phosphoinositide-3 kinase. Molecular Pharmacology. 2001, 59(3):576-585.
Garcia-Sáinz JA, García-Caballero A and González-Espinosa C. Angiotensin AT1 receptors in clone 9 rat liver cells: calcium signaling and c-fos expression. European Journal of Pharmacology. 1998, 362: 235-243.
Garcia-Sáinz JA, García-Caballero A and González-Espinosa C. Characterization of the α1-adrenoceptors of cat liver. Predominance of α1A-adrenergic subtype. Life Sciences. 1996, 59:235-242.
Gentzsch M, Dang H, Dang Y, García-Caballero A, Suchindran H, Boucher RC, Stutts MJ. The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel. J Biol Chem. 2010 Aug 13.
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