Lumb, Jean-Philip - McGill University - Department of Chemistry

个人简介

Bio | J.P. obtained his B.A. from Cornell University, where he was introduced to research by working with Bruce Ganem and Geoff Coates. In 2003, he moved to the University of California, Berkeley to pursue a Ph.D. with Dirk Trauner. As a graduate student, he worked on the biomimetic total synthesis of natural products that capitalized on complex reaction cascades triggered by oxidation. In 2008, he moved to Stanford University to pursue postdoctoral studies with Professor Barry Trost. There he developed methodologies based on palladium and copper catalysis, and also worked on the synthesis of the tricholomenyns and the complex macrolide amphidinolide N. J.P.’s training encompasses the themes of bio-inspired synthesis and catalysis, which form the cornerstones of his independent research career. In 2011, he moved to the Department of Chemistry at McGill University, where he was awarded tenure in 2017 and a Fessenden Professorship in 2018. Honors and Awards | 2019 Keith Fagnou Award (CSC) | 2018 Fessenden Professorship (McGill University) | 2016 G2C2 Young Researcher Award (York University, UK) | 2014 Thieme Chemistry Journal Young Investigator Award | 2008 Ruth L. Kirschstein Postdoctoral Fellowship (NIH) | 2006 ACS Organic Division Predoctoral Fellowship | 2002 Merck Index Award (Cornell University) Appointments Associate Professor McGill University | Department of Chemistry 2017 - present Assistant Professor McGill University | Department of Chemistry 2011 - 2017 Postdoctoral Fellow Stanford University | Department of Chemistry 2008 - 2011 Education Ph.D. Chemistry University of California, Berkeley | CA, USA 2003-2008 B.A. Chemistry | B.A. French Literature 1998-2002 Cornell University | New York, USA

研究领域

PIGMENTATION NATURAL PRODUCTS METAL ACTIVATION AEROBIC CATALYSIS

近期论文

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“A para- to meta-isomerization of phenols” Edelmann, S.; Lumb, J.-P. Nat. Chem. 2024, doi: 10.1038/s41557-024-01512-1. ‘‘Mechanisms for radical reactions initiating from N-hydroxyphthalimide esters’’ Azpilcueta-Nicolas, C. R.; Lumb, J.-P. Beilstein J. Org. Chem. 2024, doi: 10.3762/bjoc.20.35 ‘‘Mimicking Non-Canonical Radical Cyclizations in the Synthesis of Dibenzocyclooctadiene Natural Products’’ Carroll-Pöhls, M.; Lumb, J.-P. ChemCatChem 2024, doi: 10.1002/cctc.202301290 “Indole-5,6-quinones display hallmark properties of eumelanin” Wang, X.; Kinziabulatova, L.; Bortoli, M.; Manickoth, A.; Barilla, M.A.; Huang, H.; Blancafort, L.; Kohler, B.; Lumb, J.-P. Nat. Chem. 2023, doi.10.1038/s41557-023-01175-4. “Dearomatization of Biaryls through Polarity Mismatched Radical Spirocyclization” Azpilcueta-Nicolas, C. R.; Meng, D.; Edelmann, S.; Lumb, J.-P. Angew. Chem. Int. Ed. 2023, 62, e202215422. “A Bioinspired Synthesis of 1,4-Benzothiazines by Selective Addition of Sulfur Nucleophiles to ortho-Quinones” Halloran, M. W.; Li, E.; Esguerra, K. V. N.; Lumb, J.-P. J. Org. Chem. 2023, 88, 2561-2569. “Mimicking Oxidative Radical Cyclizations of Lignan Biosynthesis Using Redox-Neutral Photocatalysis" Huang, Z.; Lumb, J.-P. Nat. Chem 2021, 13, 24-32. “Total Synthesis of (S)-Cularine via Nucleophilic Substitution on a Catechol” Huang, Z.; Ji, X.; Lumb, J.-P. Org. Lett. 2021, 23, 236-241. "Regioselective Synthesis of Polyfunctional Arenes by a 4-Component Catellani Reaction" Wang, J.; Qin C.; Lumb, J.-P.; Luan, X. Chem 2020, 6, 2097-2109. “Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization" Ji, X.; Huang, Z.; Lumb, J.-P. J. Org. Chem. 2020, 85, 1062-1072. "Total Synthesis of (S,S)-Tetramethylmagnolamine via Aerobic Desymmetrization" Huang, Z.; Ji, X.; Lumb, J.-P. Org. Lett. 2019, 21, 9194-9197. “Ex Vivo Expansion of Skeletal Muscle Stem Cells with a Novel Small Compound Inhibitor of eIF2α Dephosphorylation” Lean, G.; Halloran, M. W.; Marescal, O.; Jamet, S.; Lumb J.-P.; Crist, C. Regen. Med. Front. 2019,1:e190003. “Catalytic Aerobic Cross-Dehydrogenative Coupling of Phenols and Catechols” Xu, W.; Huang, Z.; Xiang, J.; Lumb, J.-P. ACS Catal. 2019, 9, 3800-3810. “Phenol-Directed C–H Functionalization” Huang, Z.; Lumb, J.-P. ACS Catal. 2019, 9, 521-555. "Cu(III)-Mediated Aerobic Oxidations" Esguerra, K. V. N.; Lumb, J.-P. Synthesis 2019, 51, 334-358. “Recent Applications of Diazirines in Chemical Proteomics" Halloran, M. W.; Lumb, J.-P. Chem. Eur. J. 2019, 25, 4885-4898. “A Bioinspired Synthesis of Polyfunctional Indoles" Huang, Z.; Kwon, O.; Huang, H.; Fadli, A.; Marat, X.; Moreau, M.; Lumb, J.-P. Angew. Chem. Int. Ed. 2018, 57, 11963-11967. “Selectivity in the Aerobic Dearomatization of Phenols: Total Synthesis of Dehydronornuciferine by Chemo- and Regioselective Oxidation" Esguerra, K. V. N.; Lumb, J.-P. Angew. Chem. Int. Ed. 2018, 57, 1514-1518. "Catalytic Aerobic Oxidation of Halogenated Phenols" Esguerra, K. V. N.; Fall, Y.; Lumb, J.-P. Inorg. Chim. Acta. 2018, 481, 197-200. "Stopping Aerobic Oxidation in Its Tracks: Chemoselective Synthesis of Benzaldehydes from Methylarenes" Lumb, J.-P. Angew. Chem. Int. Ed. 2017, 56, 9276-9277. “A Bioinspired Catalytic Aerobic Functionalization of Phenols: Regioselective Construction of Aromatic C–N and C–O Bonds” Esguerra, K. V. N.; Lumb, J.-P. ACS Catalysis, 2017, 7, 3477-3482. "Synthesis of ortho-Azophenols by Formal Dehydrogenative Coupling of Phenols and Hydrazines or Hydrazides" Esguerra, K. V. N.; Lumb, J.-P. Chem. Eur. J. 2017, 23, 8596-8600. See the Inside Front Cover. "A Chlorine-Free Protocol for Processing Germanium" Glavinović, M.; Krause, M.; Baines, K.; Friščić, T.; Lumb, J.-P. Sci. Adv. 2017, 3, e1700149. “Development of 3,5-di-tert-Butylphenol as a Model Substrate for Biomimetic Aerobic Copper Catalysis” Kwon, O,; Esguerra, K. V. N.; Glazerman, M.; Petitjean, L.; Xu, Y.; Ottenwaelder, X.; Lumb, J.-P. Synlett, 2017, 28, 1548-1553. “A Unified Synthesis of 1,2-Oxy Amino Arenes via a Bio-Inspired Phenol / Amine Coupling” Esguerra, K.V.N.; Xu, W.; Lumb, J.-P. Chem 2017, 2, 533–549. “Second-Order Biomimicry: In Situ Oxidative Self-Processing Converts Copper(I)/Diamine Precursor into a Highly Active Aerobic Oxidation Catalyst” McCann, S.; Lumb, J.-P.; Arndtsen, B.; Stahl, S. ACS Cent. Sci. 2017, 3, 314-321.