DONG, TAO - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

2011-2013 Harvard Medical School, Banting postdoctoral fellow, Advisor: Dr. John Mekalanos 2004-2010 McMaster University, PhD, Advisor: Dr. Herb Schellhorn

研究领域

Dr. Dong is interested in the molecular adaptation mechanisms by which bacteria survive in stress environment and interact with competing species. Bacteria have developed complex regulatory networks that control gene expression to respond to different environmental stimuli from the host and the environment. Dr. Dong will use cutting-edge genomic tools such as Tn-seq, ChIP-seq, and RNA-seq to characterize key regulators and cognate targets that are important for adaptation under specific environment. Bacteria often exist in complex communities in nature. An important adaptation strategy in a polymicrobial environment is to attack competing species for invasion or self-defense through delivery of toxic molecules. Dr. Dong will work on the Type Six Secretion System (T6SS) that has been found in many human pathogens including Vibrio cholerae, Pseudomonas aeruginosa, and Salmonella species. T6SS is a bacteriophage-like nanomachine that injects antibacterial or anti-eukaryotic effectors to target cells through direct contact. Dr. Dong is interested in characterizing T6SS-dependent effectors and their contribution to fitness and interaction with eukaryotic and prokaryotic competitors.

近期论文

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Ho BT, Dong T, Mekalanos JJ (2013) A view to a kill: the bacterial type 6 secretion system. Cell Host & Microbe, accepted Dong T, Ho BT, Yoder-Himes DR, and Mekalanos JJ (2013) Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae. Proc Natl Acad Sci U S A 110:2623-2628 Dong T, Mekalanos JJ (2012) Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Res 40:7766-7775 Chiang SM, Dong T, Edge TA, Schellhorn HE (2011). Phenotypic diversity caused by differential RpoS activity among environmental Escherichia coli isolates. Applied and Environmental Microbiology 77:7915-23 Dong T, Yu R, Schellhorn HE (2011) Antagonistic regulation of motility and transcriptome expression by RpoN and RpoS in Escherichia coli. Molecular Microbiology 79:375-386 Dong T, Schellhorn HE (2010) Role of RpoS in virulence of pathogens. Infection and Immunity 78:887-897 Dong T, Schellhorn HE (2009) Global effect of RpoS on gene expression in pathogenic Escherichia coli O157:H7 strain EDL933. BMC Genomics 10:349 Dong T, Chiang SM, Joyce C, Yu R, Schellhorn HE (2009) Polymorphism and selection of rpoS in pathogenic Escherichia coli. BMC Microbiology 9:118 Dong T, Coombes BK, Schellhorn HE (2009) Role of RpoS in the virulence of Citrobacter rodentium. Infection and Immunity 77:501-507 Dong T, Schellhorn HE (2009) Control of RpoS in global gene expression of Escherichia coli in minimal media. Molecular Genetics and Genomics 281:19-33 Dong T, Kirchhof MG, Schellhorn HE (2008) RpoS regulation of gene expression during exponential growth of Escherichia coli K12. Molecular Genetics and Genomics 279: 267-277