Chik, John - Mount Royal University - Department of Chemistry and Physics

个人简介

PhD, Princeton University B.Sc. University of Toronto

研究领域

Dr. John Chik's interest in questions that lie at the intersection of biology, chemistry and physics was planted when, as a graduate student at Princeton University, he became fascinated by how living organisms exploit adenosine triphosphate hydrolysis as an energy source for mechanical processes such as muscle contraction. His current research focus deals with elucidating how the “crowded” environment within living cells affect enzyme function. Enzymes are the molecular “machines” that facilitate life-enabling chemical reactions. Much of our current insights into how these amazing molecules operate has been gained through experiments conducted under highly dilute solution conditions very different from their native environments. Dr. Chik and his students has been using neutral solutes to simulated the crowded intracellular milieu and interpreting their data through using a combination of Michaelis-Menten kinetics and osmotic stress. Finally, Dr. Chik is very interested in exploring and improving the role of laboratory and other forms of experiential instruction in science education such as community service learning. He has implemented a novel laboratory pedagogy, referred to as REAL labs (REAL - Real Experience and Learning) in his two third-year biochemistry classes, BCEM 3201 and BCEM 3202

近期论文

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MacDonald, J.A., Ulke-Lemee, A., Butler, E.I., Ishida, H., Chappellaz, M., Chik, J.K., & Vogel, H.J. (2012, April 3). The intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding. Biochemistry, 51(13), 2694-2705. Chik, J.K. (2012). In. (R. Bissessur, G.R. Loppnow, N.J. Mosey, J. Carran, & J.K. Chik, Eds.), Chemistry, Student Activity, Chemical Reactivity (pp.443-456). Scarborough: Nelson. (Status: In Print). Chik, J.K., Schriemer, D.C., Childs, S.J., & McGhee, J.D. (2011). Proteome of the Caenorhabditis elegans Oocyte. Journal of Proteome Research, 10(2300), 2305. Bennet, M., Chik, J.K., Slysz, G.W., Luchko, T., Tuszynski, J., Sackett, D.L., & Schriemer, D.C. (2009). Structural mass spectrometry of the αβ-tubulin dimer supports a revised model of microtubule assembly. Biochemistry, 48, 4858-4870. Huzil, J.T., Chik, J.K., Slysz, G.W., Freedman, H., Tuszynski, J., Taylor, R.E., Sackett, D.L., & Schriemer, D.C. (2008). Discovery of the peloruside binding site on microtubules and a unique mechanism of microtubule stabilization. Journal of Molecular Biology, 378, 1016-1030 (In Print). Chik, J.K., Vande Graaf, J.L., & Schriemer, D.C. (2006). Quantitating the statistical distribution of deuterium incorporation extends the utility of H/D exchange MS data. Analytical Chemistry, 78, 207-214 (In Print). Chik, J.K., Mizrahi, S., Chi, S., Parsegian, V.A., & Rau, D.C. (2005). Hydration forces underlie the exclusion of salts and neutral polar solutes from hydroxypropylcellulose. Journal of Physical Chemistry B, 109, 9111-9118 (In Print). Lovelace, J., Narayan, K., Chik, J.K., Bellamy, H.D., Snell, E.H., Lindberg, U., Schutt, C.E., & Borgstahl, G.E.O. (2004). Three dimensional imaging of reflections from a modulated semi-crystalline state of profilin:actin. Journal of Applied Crystallography, 37, 327-330 (In Print). Chik, J.K., & Schriemer, D.C. (2003). Hydrogen/deuterium exchange mass spectrometry of actin in various biochemical contexts. Journal of Molecular Biology, 334, 373-385 (In Print). Cheng, Y., Prud'homme, R.K., Chik, J.K., & Rau, D.C. (2002). Measurement of forces between galactomannan polymer chains: Effect of hydrogen bonding. Macromolecules, 35, 10155-10161 (In Print). Chik, J.K., & Parsegian, V.A. (2001). The entropically favored osmotic 'compression' of sickle cell hemoglobin gels. Biopolymers, 59, 120-124 (In Print). Chik, J.K., Lindberg, U., & Schutt, C.E. (1996). An open-state of bovine profilin:ÃŸ-actin at 2.65Ã… resolution. Journal of Molecular Biology, 263, 607-623