BRAIN, MICHAEL - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

M.D. (Doctor of Medicine)

研究领域

The role of sialylated glycoproteins and glycolpids in hemolysis and in stabilizing the membrane of erythrocytes and cardiomyocytes.with an increased exposure of phosphatidylethanolamine (PE) as detected by increased calcium permeability and increased fluorescent labeling with cinnamycin. These studies will be carried in collaboration with Dr Henk ter Keurs.

近期论文

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Life-threatening hemolytic anemia due to an autoanti-Pr cold agglutinin: evidence that glycophorin A antibodies may induce lipid bilayer exposure and cation permeability independent of agglutination.Brain MC, Ruether B, Valentine K, Brown C, ter Keurs H. Evidence for a mechanosensitive calcium influx into red cells.Brain MC, Pihl C, Robertson L, Brown CB.Blood Cells Mol Dis. 2004 May-Jun;32(3):349-52. Glycophorin A-mediated haemolysis of normal human erythrocytes: evidence for antigen aggregation in the pathogenesis of immune haemolysis.Brain MC, Prevost JM, Pihl CE, Brown CB.Br J Haematol. 2002 Sep;118(3):899-908. Erratum in: Br J Haematol. 2002 Dec;119(3):886..