BOSE, PINAKI - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Dr. Pinaki Bose completed his Ph.D. in basic cancer research with Dr. Karl Riabowol at the University of Calgary, investigating the role of the ING1 tumour suppressor protein in DNA damage signaling and apoptosis. After completing his Ph.D., Pinaki joined the Ohlson Research Initiative (ORI) as a postdoctoral fellow and trained in the molecular epidemiology of head and neck cancers under the supervision of Drs. Joseph Dort and Nigel Brockton. As part of a second postdoctoral fellowship, Pinaki trained at the BC Cancer Agency (BCCA) Genome Sciences Centre in cancer genomics and bioinformatics under one of the leading bioinformaticians in the world, Dr. Steven Jones. Pinaki was also a member of the personalized oncogenomics (POG) program at the BCCA. The POG initiative administers targeted therapies to recurrent/metastatic cancer patients based on their genomic profiles. Dr. Bose currently directs the translational research program at the ORI, a multidisciplinary head and neck cancer research initiative working in close collaboration with surgeons, pathologists, bioinformaticians, statisticians and basic researchers. The Bose lab is investigating the biology of head and neck cancers with particular emphasis on mechanisms regulating lymph node metastasis (LNM). LNM is a potent predictor of worse prognosis in oral cancers, one of the most common cancers of the head and neck region. Towards this end, we are developing genome-wide screens in oral cancer cell lines and animal models to identify regulators of LNM. Another focus in the Bose lab is performing integrative analyses of multidimensional genomic datasets from the Cancer Genome Atlas (TCGA) and the Genomics of drug sensitivity project (Sanger Institute). These analyses help identify aberrant signaling pathways that might serve as therapeutic targets in oral cancers and the drugs that may target these pathways. Such in silico analyses inform experiments in cell lines and orthotopic xenograft models to test the efficacy of candidate drugs and mechanisms underlying drug sensitivity and resistance. Finally, the lack of prognostic and predictive markers in oral cancer limits treatment options in this cancer type. We have assembled tissue microarrays (TMAs) from a cohort of oral cancer patients with matched normal oral cavity squamous epithelium, oral cancer and lymph node metastasis samples. Robust and dynamically updated clinical data for this cohort is available in the ORI database. Both fresh frozen and FFPE issue cores are also available for genomic analyses. Using these resources we are developing prognostic biomarkers and signatures that will better stratify oral cancer patients and inform treatment options to improve disease outcomes.

近期论文

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Terry Fox Research Institute Glioblastoma Consortium (2016). Comparative genomic and genetic analysis of glioblastoma-derived brain tumor-initiating cells and their parent tumors. Neuro Oncology 18(3):350-60 DOI: 10.1093/neuonc/nov143 Bose, P., Pleasance, E. D, Jones, M., Shen, Y., Ch’ng, C., Reisle, C., Schein, J. E., Mungall, A., Moore, R., Ma, Y., Sheffield, B. S., Thomson, T., Lee, C., Yip, S., Marra M. A., Laskin, J., Ho, C., Jones, S. J. M. (2015) Integrative genomic analysis of ghost cell odontogenic carcinoma. 51(9):e71-5. Oral Oncology DOI: 10.1016/j.oraloncology. 06.013 Cusulin, C., Chesnelong, C., Bose, P., Bilenky, M., Kopciuk, K., Chan, J. A., Cairncross, J. G., Jones, S. J. M., Marra, M. A., Luchman, H. A., Weiss, S. (2015) Precursor states of brain tumor initiating cell lines are predictive of survival in xenografts and associated with glioblastoma subtypes. Stem Cell Reports S2213-6711(15)00153-8. DOI: 10.1016/j.stemcr.2015.05.010 Bose, P., Brockton, N. T., Guggisberg, K., Nakoneshny, S., Kornaga, E., Klimowicz, A. C., Tambasco, M., Dort, J. C. Fractal analysis of nuclear histology integrates tumor and microenvironment into a single prognostic factor in OSCC. BMC Cancer 15:409 DOI: 10.1186/s12885-015-1380-0 Dang, M., Lysack, J. T., Wu, T., Matthews, T. W., Chandarana, S. P., Brockton, N. T., Bose, P., Bansal, G., Cheng, H., Mitchell J. R., Dort, J. C. (2015) MRI texture analysis predicts p53 status in head and neck squamous cell carcinoma. AJNR Am J Neuroradiol 36(1):166-70. DOI: 10.3174/ajnr.A4110 Bose, P., Thakur, S., Klimowicz, A. C., Kornaga, E., Nakoneshny, S., Brockton, N. T., Riabowol, K. and Dort, J. C. (2014) Cytoplasmic ING1 expression measured by AQUAnalysis® is an independent prognostic marker in oral squamous cell carcinoma. Oncotarget 5(10):3210-9 Bose, P., Thakur, S., Thallapilly, S., Ahn, B-Y., Kim, S-W., Riabowol, K. (2013) ING1 induces apoptosis through direct effects at the mitochondria. Cell Death and Disease 4:e788. DOI: 10.1038/cddis.2013.321 Klimowicz, A. C., Bose, P., Petrillo, S., Chandarana, S., Wayne Matthews, T., Dort, J. C., Brockton, N. T. (2013) The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma; British Journal of Cancer DOI: 10.1038/bjc.2013.533 Bose, P., Dort, J. C., Brockton, N. T. (2013) Identifying the stromal cell type that contributes to tumor aggressiveness associated with carbonic anhydrase IX. Cell Cycle 12(16): 2535 Bose, P., Brockton, N. T. Dort, J. C. (2013) Head and Neck Cancer: From Structure to Biology. International Journal of Cancer 133(9): 2013-2023 Bose, P.*, Klimowicz, A. C.*, Thakur, S., Brockton, N. T., Dean, M., Nakoneshny, S., Wayne Matthews, T., Dort, J. C. (2012) Basal Ki67 expression in the tumour drives prognosis in oral squamous cell carcinoma. European Journal of Cancer 48(14):2166-2174. *shared first authorship Bose, P., Klimowicz, A. C., Brockton, N. T., Petrillo, S., Wayne Matthews, T., Easaw, J., Magliocco, A., Dort, J. C. (2012) Bax expression measured by AQUAnalysis® is an independent prognostic marker in oral squamous cell carcinoma. BMC Cancer 12(1):332 Brockton, N.T., Klimowicz, A. C., Bose, P., Petrillo, S., Konno, M., Rudmik, L., Dean, M. Nakoneshny, S., Lau, H. Y., Wayne Matthews, T., Magliocco, A., Dort, J. C. (2012) High stromal carbonic anhydrase IX Expression is associated with nodal metastasis and decreased survival in surgically-treated oral cavity squamous cell carcinomas. Oral Oncology 48(7):615-622 Bose, P.*, McIntyre, J.B.*, Klimowicz, A.C., Brockton, N.T., Petrillo, S., Wayne Matthews, T., Easaw, J., Magliocco, A., Dort, J. C. (2012) Highly-Specific and Sensitive Hydrolysis Probe-Based Real-Time PCR Detection of Epidermal Growth Factor Receptor Variant III in Oral Squamous Cell Carcinoma. PLoS ONE 7: e31723. *shared first authorship Jayanthan, A., Bernoux, D., Bose, P., Riabowol, K., Narendran, A. (2011) Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-1 inhibition. Cancer Cell International 11(1):44 DOI: 10.1186/1475-2867-11-44 Bose, P.*, Suzuki, K*, Leong-Quong, R., Fujita, D. J. and Riabowol, K. (2010) REAP: A two minute subcellular fractionation method. BMC Research Notes 3:294 DOI: 10.1186/1756-0500-3-294 *shared first authorship Tamannai, M., Farhangi, S., Truss, M., Sinn, B., Wurm, R., Bose, P., Henze, G., Riabowol, K., von Deimling, A., Tallen, G. The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. Oncology Research 18:469-80 (2010) Han, X., Feng, X., Rattner, J. B., Smith, H., Bose, P., Suzuki, K., Soliman, M. A., Scott, M. S., Burke, B. E., Riabowol, K. (2008) Tethering of the ING1 PHD protein to lamin A is required for ING1 stability and function in apoptosis. Nature Cell Biology 10: 1333-1340 Gordon, P. M. K., Soliman, M. A., Bose, P., Trinh, Q., Sensen, C.W., Riabowol, K. (2008) Interspecies data mining to predict novel protein-protein interactions in human. BMC Genomics 9: 426-440 DOI: 10.1186/1471-2164-9-426 Bose, P., Ganapathy, A., Riabowol, K. Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells. (2010) Epigenetics of Aging pgs. 227-255 Bose, P., Riabowol, K. Replicative senescence and the aging cell cycle. (2008)Trends in Cell Cycle Research pgs. 1-30