YATES, ROBIN - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)

研究领域

Phagocytes are cells named for their ability to engulf or "eat" particulate material via the process of phagocytosis. They function in a diverse array of essential tasks throughout the body, operating at the frontlines to protect the body against invading microbes and also performing numerous housekeeping functions that are necessary for normal growth and maintenance of health. The phagosome is the organelle that is formed within the phagocyte following phagocytosis and is charged with the task of processing the engulfed material appropriately. In primitive phagocytes, such as the amoeba, this organelle serves as the "stomach" of the cell and acts to efficiently and completely digest its contents for cellular nutrition. In phagocytes of higher order organisms, however, the phagosome can be charged to perform a multitude of precise functions, many of which rely on controlled or partial deconstruction of engulfed material. Phagocytes such as macrophages and dendritic cells can adapt the lumenal chemistries within the phagosome to best suit the task at hand. This allows these cells to perform numerous tasks within the body. However, with increased versatility comes increased fallibility which can lead to disease. The Yates lab focuses its research on the lumenal environment within phagosomes in macrophages and dendritic cells. By utilizing techniques in fluorometry, microscopy and molecular biology the group can monitor chemistries within this microenvironment; explore relationships between phagosomal chemistries and dissect pathways that alter phagosomal function. Since phagosomes play key roles in numerous physiologies and pathologies, this fundamental work has the potential to impact a diverse array of biomedical fields from tuberculosis to atherosclerosis and to influence the design of vaccines and drug delivery technologies.

近期论文

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Rybicka, J.M., Balce, D.R., Chaudhuri, S., Allan, E.R.O., and Yates, R.M. (2012). Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. The EMBO Journal. [Early online edition] Balce D.R., Li B., Allan E.R.O., Rybicka J.M., Krohn R.M., and Yates R.M. (2011) Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms. Blood. 118(15):4199-208. [view] Lemmon JC, McFarland RJ, Rybicka JM, Balce DR, McKeown KR, Krohn RM, Matsunaga TO, Yates RM. (2011). In vitro and in vivo transfection of primary phagocytes via microbubble-mediated intraphagosomal sonoporation. J Immunol Methods. 371(1-2):152-8. [view]