个人简介

M.D. (Doctor of Medicine)

研究领域

Cell Signalling and Structure

The research focus in my laboratory has been in three areas: 1) Metabolomics in human diseases in Critical Care. We continue to study serum metabolomics in sepsis, lung injury and head injury. 2) Gene regulation in sepsis. We have examined gene regulation in macrophages in sepsis with a focus on the alternative complement cascade Factor B and have examined IGF-I gene regulation in lungs with an interest in acute and chronic lung fibroproliferation. 3) Clinical/Translational studies on sepsis. We have participated in a number of sepsis clinical studies. To this end, I have created a Critical Care Tissue bank to conduct translational research on clinically important problems in the ICU and have also created a wet lab within the ICU to manage samples. My laboratory is particularly interested in conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.

近期论文

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Lalu M.M. ; McIntyre, L.; Pugliese, C.; Fergusson, D.; Winston, B.W.; Marshall, J.C.; Granton, J.; Stewart D.J.; and the Canadian Critical Care Trials Group. Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): a systematic review of clinical trials. PLoS One. 2012;7(10):e47559. Deirdre Church, Ingrid Slaba, Brent Winstonand Robert Lindsay. Burn Wound Infections. In The Prokaryotes:The Prokaryotic Biology and Symbiotic Associations, 4th Edition. Eugene Rosenberg Editor. (Published 2013 on line: www.springerreference.com). Beata Mickiewicz, Hans J Vogel, Hector R Wong, and Brent W. Winston. Metabolic profiling of serum samples by 1H NMR spectroscopy as a novel approach for early prognostic evaluation of pediatric septic shock and its mortality. Am. J. Respir. Crit. Care Med. rccm.201209-1726OCFirst published online March 7, 2013 as doi:10.1164/rccm.201209-1726OC Beata Mickiewicz; Gavin E. Duggan; Brent W. Winston; Christopher Doig; Paul Kubes; Hans J. Vogel for the Alberta Sepsis Network (ASN). Metabolic profiling of serum samples by 1H NMR spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med. First published online Dec 23, 2013. [Epub ahead of print]. Print version, CCM, 2014, 42(5):1140-1149. Mohammad M. Banoei, Sarah J. Donnelly, Beata Mickiewicz, Aalim Weljie, Hans J. Vogel and Brent W. Winston. Metabolomics in critical care medicine, a new approach to biomarker discovery. Clinical and Investigative Medicine, 37(6), 2014, E363-376. Graciela Andonegui, Peter M. Krein, Connie Mowat, Ron Brisebois, Christopher Doig, Francis Green, Caroline Léger and Brent W. Winston. Enhanced production of IGF-I in the lungs of fibroproliferative ARDS patients. Physiol Rep, 2(11), 2014, e12197, doi: 10.14814/phy2.12197. Beata Mickiewicz, Patrick Tam, Craig N. Jenne, Caroline Leger, Josee Wong, Brent W. Winston, Christopher Doig, Paul Kubes and Hans J. Vogel for the Alberta Sepsis Network (ASN). Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit. Critical Care 2015, 19 :11 (15 January 2015). doi:10.1186/s13054-014-0729-0. Mehdi Mirsaeidi, Mohammad Mehdi Banoei, Caleb K. Nienow, Taimur Abassi, Anoushirvan Hakim, Dean Schraufnagel, Brent W. Winston, Nadera Sweiss, Robert Baughman, Joe G.N. Garcia, Roberto Machado. Plasma metabolomics profile in fibrosing pulmonary sarcoidosis. Accepted for publication in Sarcoidosis, 2015. Mehdi Mirsaeidi, Mehdi Mohammad Banoei, Brent W. Winston, Dean E. Schraufnagel. Metabolomics: Applications and Promise in Mycobacterial Disease. Ann Am Thorac Soc. 2015 Jul 21. [Epub ahead of print]. Beata Mickiewicz, Graham Thompson, Jaime Blackwood, Craig N Jenne, Brent W Winston, Hans J Vogel, and Ari R Joffe for the Alberta Sepsis Network. Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis. Crit Care. 2015 Sep 9;19:320. doi: 10.1186/s13054-015-1026-2. A A Mourad, M M Banoei, S J Donnelly, and B W Winston. Predicting the mortality of pneumonia-induced direct lung injury using serum metabolomics. Extended abstract, Journal of Undergraduate Research in Alberta (JURA)­, Vol. 5, 2015. Yipp, BG, Winston, BW. Sepsis without SIRS is still sepsis. Ann Transl Med, 2015. doi: 10.3978/ j.issn.2305-5839.2015.11.13.