SHI, YAN - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

M.D. (Doctor of Medicine) Ph.D. (Doctor of Philosophy)

研究领域

Cell Signalling and Structure

近期论文

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Oskouie FG, Shameli A, Yang A, Desrosiers MD, Mucsi AD, M.R.Blackburn, Yang Y , Santamaria P, and Y.Shi. 2011 High levels of adenosine deaminase on dendritic cells promote autoreactive T cell activation and diabetes in NOD mice. J Immunol 2011. Accepted In press. Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, Ward SM, Seamone ME, Vilaysane A, Mucsi AD, Fong Y, Prenner E, Ling CC, Tschopp J, Muruve DA, Amrein MW, Y.Shi. Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat Med. 2011 Apr;17(4):479-87. ( Preview in Nature medicine) Ping Wang, Wenwen Xu, Björn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom Mann, Yan Shi, Paul Kubes & Dianqing Wu 2010 Important Roles of PIP5K1C in Neutrophil Recruitment Immunity, 33(3): 340-350 Shi, Y. 2010 Caught red-handed: uric acid is an agent of inflammation. J Clin Invest.120(6):1809-11 Yang, A., A. D. Mucsi, M. D. Desrosiers, J. F. Chen, J. B. Schnermann, M. R. Blackburn, and Y. Shi. 2010. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40:449-459. Shi, Y., A. D. Mucsi, and G. Ng. 2010. Monosodium urate crystals in inflammation and immunity. Immunol Rev 233:203-217. Kanevets, U., K. Sharma, K. Dresser, and Y. Shi. 2009. A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity. J Immunol 182:1912-1918. Kanevets, U., K. Sharma, K. Dresser, and Y. Shi. 2009. A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity. J Immunol 182:1912-1918. Yang, A., A. D. Mucsi, M. D. Desrosiers, J. F. Chen, J. B. Schnermann, M. R. Blackburn, and Y. Shi. 2010. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40:449-459. Yang, A., A. D. Mucsi, M. D. Desrosiers, J. F. Chen, J. B. Schnermann, M. R. Blackburn, and Y. Shi. 2010. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40:449-459. Y. Shi and M.D. Desrosiers 2008. Recent Developments in Immunology: Adenosine receptor 1 and adenosine deaminase in the regulation of dendritic cells. Editor: Jim Xiang p265-27. Transworld Research Network Ng, G., K. Sharma, S. M. Ward, M. D. Desrosiers, L. A. Stephens, W. M. Schoel, T. Li, C. A. Lowell, C. C. Ling, M. W. Amrein, and Y. Shi. 2008. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and syk kinase activation in dendritic cells. Immunity 29:807-818 . ( Preview in Immunity ; Editor's Choice in Science ). Ueno, A., J. Wang, L. Cheng, J. S. Im, Y. Shi, S. A. Porcelli, and Y. Yang. 2008. Enhanced early expansion and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese diabetic mice. J Immunol 181:6789-6796 . Wang, J., S. Cho, A. Ueno, L. Cheng, B. Y. Xu, M. D. Desrosiers, Y. Shi, and Y. Yang. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181:2438-2445 . Desrosiers, M. D., K. M. Cembrola, M. J. Fakir, L. A. Stephens, F. M. Jama, A. Shameli, W. Z. Mehal, P. Santamaria, and Y. Shi. 2007. Adenosine deamination sustains dendritic cell activation in inflammation. J Immunol 179:1884-1892 . Chen, C. J., Y. Shi, A. Hearn, K. Fitzgerald, D. Golenbock, G. Reed, S. Akira, and K. L. Rock. 2006. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116:2262-2271. Shi, Y., S. A. Galusha, and K. L. Rock. 2006. Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model. J Immunol 176:3905-3908 . Rock, K. L., A. Hearn, C. J. Chen, and Y. Shi. 2005. Natural endogenous adjuvants. Springer Semin Immunopathol 26:231-246. Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516-521 . Shi, Y., and K. L. Rock. 2002. Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens. Eur J Immunol 32:155-162.