研究领域
My work focuses on two inter-related areas of developmental neurobiology: 1) pattern formation within the developing central nervous system of the vertebrate embryo and 2) the ontogeny of distinct neuronal systems. More specifically, I am interested in defining the cellular and molecular mechanisms involved in setting up positional information along the rostral-caudal and medial-lateral axis within developing mes/metencephalic derivatives. In addition, I have recently begun to investigate the molecular cues involved in the differentiation of specific neuronal cell types and establishment of neuronal circuitry within the developing cranial sensory system. I use the chick embryo as a model system in which to explore both of these issues and utilize a multidisciplinary approach which combines techniques in molecular biology, electroporation and retroviral-mediated gene transfer, microsurgery, cell and tissue culture, anterograde labelling, as well as immunohistochemistry.
近期论文
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An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TM, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJ, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJ, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF; UK10K Consortium.; University of Washington Center for Mendelian Genomics., Stewart F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA.Nat Cell Biol. 2015 Aug;17(8):1074-87. doi: 10.1038/ncb3201.
Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C.Gene Expr Patterns. 2014 Jan;14(1):42-54. doi: 10.1016/j.gep.2013.10.003.
Ascl1 participates in Cajal-Retzius cell development in the neocortex.Dixit R, Zimmer C, Waclaw RR, Mattar P, Shaker T, Kovach C, Logan C, Campbell K, Guillemot F, Schuurmans C.Cereb Cortex. 2011 Nov;21(11):2599-611. doi: 10.1093/cercor/bhr046.
Micro-computed tomography-based phenotypic approaches in embryology: procedural artifacts on assessments of embryonic craniofacial growth and development.Schmidt EJ, Parsons TE, Jamniczky HA, Gitelman J, Trpkov C, Boughner JC, Logan CC, Sensen CW, Hallgrímsson B.BMC Dev Biol. 2010 Feb 17;10:18. doi: 10.1186/1471-213X-10-18.
Fast interactive integration of cross-sectional image datasets and surface data for morphometric analysis.Meruvia-Pastor O, Soh J, Xiao M, Schmidt E, Logan C, Boughner JC, Jones N, Osborn D, Santiago J, Gittleman J, Hallgrímsson B, Sensen CW.Stud Health Technol Inform. 2009;142:183-8.
Gene transfer in avian embryos using replication-competent retroviruses.Logan C, Francis-West P.Methods Mol Biol. 2008;461:363-76. doi: 10.1007/978-1-60327-483-8_26. Review. No abstract available.
Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalon.Langevin LM, Mattar P, Scardigli R, Roussigné M, Logan C, Blader P, Schuurmans C.Dev Dyn. 2007 May;236(5):1273-86.
Isolation and characterization of the leucine-rich proteoglycan nyctalopin gene (cNyx) from chick.Bech-Hansen NT, Cockfield J, Liu D, Logan CC.Mamm Genome. 2005 Oct;16(10):815-24.
Ltrk is differentially expressed in developing and adult neurons of the Lymnaea central nervous system.Bulloch AG, Diep CQ, Logan CC, Bulloch ES, Robbins SM, Hislop J, Sossin WS.J Comp Neurol. 2005 Jul 4;487(3):240-54.
Electroporation of proviral RCAS DNA alters gene expression in the embryonic chick hindbrain.Hermann PM, Logan CC.Biotechniques. 2003 Nov;35(5):942-6, 948-9.
Onset of Tlx-3 expression in the chick cerebellar cortex correlates with the morphological development of fissures and delineates a posterior transverse boundary.Logan C, Millar C, Bharadia V, Rouleau K.J Comp Neurol. 2002 Jun 24;448(2):138-49.
Gene transfer in avian embryos using replication-competent retroviruses.Logan C, Francis-West P.Methods Mol Biol. 1999;97:539-51. No abstract available.
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