HUANG, CAROL - University of Calgary - Department of Biochemistry & Molecular Biology

个人简介

M.D. (Doctor of Medicine) Ph.D. (Doctor of Philosophy)

研究领域

Our lab is interested in understanding the molecular mechanisms that regulate beta cell mass and function, using pregnancy as the model. We have found that intact prolactin receptor signaling is required for normal glucose homeostasis and beta cell mass expansion during pregnancy. We will now examine 1) whether beta-cell neogenesis occurs during pregnancy, 2) what are the signalling pathways required for the increase in beta-cell mass during pregnancy, and 3) whether pregnancy hormones can improve glucose homeostasis in animal models of type 1 and type 2 diabetes, or the outcomes of islet transplantation. Another area of research is to delineate whether adipokines, hormones secreted by adipocyte, which affect whole body insulin sensitivity, also regulates pancreatic beta-cell mass and function. We also has clinical collaborations examining the relationship between adipokine, obesity, and risk of cardiovascular diseases in children with diabetes.

近期论文

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Hyslop C, Tsai S, Shrivastava V, Santamaria P, and Huang C. Prolactin as an adjunct for type 1 diabetes immunotherapy. Endocrinology 2015, (Epub ahead of print) Rawn S, Huang C, Hughes M, Shaykhutdinov R, Vogel HJ, and Cross JC. Pregnancy hyperglycemia in prolactin receptor mutant, but not prolactin mutant, mice and feeding-responsive regulation of placental lactogens genes implies placental control of maternal glucose homeostasis. Biology of Reproduction 2015, August 12; pii: biolreprod. 115. 132431. Toselli C, Hughes M, Hyslop C, Natale DR, Santamaria P, and Huang C. Contribution of a non-β-cell source to β-cell mass during pregnancy. PLOS ONE 2014, Jun 18; 9 (6):e100398 Huang C. Wild type offspring of heterozygous prolactin receptor null female mice have maladaptive beta-cell responses during pregnancy. Journal of Physiology 2013, Mar 1; 591 (Pt5): 1325-38. Ho J, Huang C, Nettel-Aguirre A, and Pacaud D. Insulin Detemir in a twice daily insulin regimen versus a three times daily insulin regimen in the treatment of type 1 diabetes in children: A pilot randomized controlled trial. International Journal of Pediatric Endocrinology 2011, Nov (1): 15. Hughes E and Huang C. Participation of Akt, menin and p21 in pregnancy-induced b-cell proliferation. Endocrinology 2011, Mar, 152 (3): 847-855. Martinez-Soto T, Pacaud D, Stephure D, Trussell R, and Huang C. Treatment of symptomatic osteoporosis in children: A comparison of two pamidronate dosage regimens. Journal of Pediatric Endocrinology and Metabolism 2011, June, 24:271-274. (Senior author)