个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Genomics Proteomics and Bioinformatics

(1) big data analysis for interpreting data, generating, prioritizing and testing new hypotheses; (2) developing novel algorithms for modeling of molecular networks and diseases for precision medicine applications; (3) conducting systems biology research by applying both computational and experimental approaches; (4) method development in statistical modeling, machine learning and deep learning.

近期论文

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Shanwu Gao, Chabane Tibiche, Jinfeng Zou, Naif Zaman, Mark Trifiro, Maureen O’Connor-McCourt, and Edwin Wang, Identification and Construction of Combinatory Cancer Hallmark-Based Gene Signature Sets to Predict Recurrence and Chemotherapy Benefit in Stage II Colorectal Cancer, JAMA Oncology, on-line (PDF), Supplemental Material (PDF), 2015 (JAMA, NEJM and Lancet are the 3 top clinical journals), Reuters News, PMID: 26502222 Zaman N. …. Edwin Wang, Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets, Cell Reports (a new Cell sister journal), 5:216-223, 2013, Paper in Cell Press, PMID: 24075989 Li L., Fu C., Tibiche C., Kaneko T., Schiller M., Li S., Wang, Edwin, The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer, Genome Research, 22:1222-30, 2012, Paper in Genome Res, Highlighted in 7th Annual RECOMB Systems Biology, 2011, PMID: 22194470 Li. J., Lenferink, AE., Cantin, C., Purisima EO., O’Connor-McCourt, MD., and Edwin Wang, Identification of high quality cancer prognostic markers and metastasis network modules, Nature Communications, 1:34, 2010, Paper in Nature Communications. GEN's Tech Tips: Protein Biomarker Discovery, 2010. Commentary,NRC Highlights, PMID: 20975711 Cui Q, Ma Y, Jaramillo M, Bari H, Awan A, Yang S, Zhang S, Liu L, Lu M, O'Connor-McCourt M, Purisima EO, Edwin Wang, A map of human cancer signaling, (Nature/EMBO) Molecular Systems Biology, 3:152, 2007, Paper in Molecular Systems Biology (MSB), Highlighted in Genome Technology Magazine (PDF), Highlight Track in 16th International Conference of ISMB, 2008, NRC Highlights PMID:16969338 Cui Q, Yu Z, Purisima EO, Wang Edwin, MicroRNA regulation and cross-species variation of gene expression, Trends Genet., 23:372-375, 2007, PDF, Paper in Cell Press Cui Q, Yu Z, Purisima EO, Wang Edwin, Principles of microRNA regulation of a human cellular signaling network, (Nature/EMBO) Molecular Systems Biology, 2:46, 2006, Paper in Molecular Systems Biology (MSB) PMID:16969338 Edwin Wang*, Purisima E., Network motifs are enriched with transcription factors whose transcripts have short half-lives, Trends Genet. 21:492-495, 2005, PDF, Paper in Cell Press Edwin Wang* et al., Predictive Genomics: A cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data, Seminars in Cancer Biology (Invited review), 2014, PDF, PMID: 24747696 Edwin Wang* et al., Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks, Seminars in Cancer Biology (Invited Review), 23:279-285,2013, PDF, PMID: 23791722 Edwin Wang* et al., Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance, Seminars in Cancer Biology (Invited Review), 23:286-292,2013, PDF, PMID: 23792107 Edwin Wang, A roadmap of cancer systems biology, In Edwin Wang (ed), Cancer Systems Biology, CRC Press, 2010, PDF, Nature Precedings, 2010