个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Cell Signalling and Structure

Signal transduction pathways involved in the regulation of excitation-contraction coupling in smooth muscle, particularly of the vasculature. Specific areas of interest include: Ca2+-sensitization of smooth muscle contraction Ca2+-independent phosphorylation of myosin and contraction The molecular basis of myogenic tone in the vasculature (in collaboration with Dr. Bill Cole) Functional interactions between Rho-associated kinase and zipper-interacting protein kinase in vascular smooth muscle cells (in collaboration with Dr. Justin MacDonald)

近期论文

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Castro, M. M., Cena, J., Cho, W. J., Walsh, M. P. and Schultz, R. (2012) Arterioscler. Thromb. Vasc. Biol. 32: 662-668. Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats. Li, J., Jiang J., Yin, H., Wang, L., Tian, R., Li, H., Wang, Z., Li, D., Wang, Y., Gui, Y., Walsh, M. P.and Zheng, X-L. (2012) Hypertension 60: 145-153. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Sutherland, C. and Walsh, M. P. (2012) J. Biol. Chem. 287: 24064-24076. Myosin regulatory light chain diphosphorylation slows relaxation of arterial smooth muscle. Grassie, M. E., Sutherland, C., Ulke-Lemée, A., Chappellaz, M., Kiss, E., Walsh, M. P. and MacDonald, J. A. (2012) J. Biol. Chem. 287: 36356-36369. Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent protein kinase signaling pathways in the regulation of smooth muscle myosin light chain phosphatase. MacDonald, J. A., Moffat, L. D., Al-Ghabkari, A., Sutherland, C. and Walsh, M. P. (2013) Arch. Biochem. Biophys. 535: 84-90. Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle. Moreno-Domínguez, A., Colinas, O., El-Yazbi, A., Walsh, E. J., Hill, M. A., Walsh, M. P. and Cole, W. C. (2013) J. Physiol. 591: 1235-1250. Ca2+ sensitization due to myosin light chain phosphatase inhibition and cytoskeletal reorganization in the myogenic response of skeletal muscle resistance arteries. Yuan, W., Wang, Z., Li, J., Li, D., Liu, D., Bai, G., Walsh, M. P., Gui, Y. and Zheng, X-L. (2013)IUBMB Life 65: 623-632. Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscles by distinct signaling pathways. Mita, M., Tanaka, H., Yanagihara, H., Nakagawa, J., Hishinuma, S., Sutherland, C., Walsh, M. P.and Shoji, M. (2013) J. Smooth Muscle Res. 49: 26-45. Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation. [One of two articles chosen as best article of 2013]. Carlson, D. A., Franke, A. S., Weitzel, D. H., Speer, B. L., Hughes, P. F., Hagerty, L., Fortner, C. N., Veal, J. M., Barta, T. E., Zieba, B. J., Somlyo, A. V., Sutherland, C., Deng, J. T., Walsh, M. P., MacDonald, J. A. and Haystead, T. A. J.(2013) ACS Chem. Biol. 8: 2715-2723. Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. Jamshidiha, M., Ishida, H., Sutherland, C., Gifford, J. L., Walsh, M. P. and Vogel, H. J. (2013) J. Biol. Chem. 288: 32036-32049. Structural analysis of a calmodulin variant from rice: The C-terminal extension of OsCaM61 regulates its calcium binding and enzyme activation properties. Hong, F., Facemyer, K. C., Carter M. S., Jackson, D. R., Haldeman, B. D., Ruana, N., Sutherland, C., Walsh, M. P., Cremo, C. R. and Baker, J. E. (2013) Biochemistry 52: 8489-8500. Kinetics of myosin light chain kinase activation of smooth muscle myosin in an in vitro model system. Walsh, M. P. and Cole, W. C. (2013) J. Cereb. Blood Flow Metab. 33: 1-12. The role of actin filament dynamics in the myogenic response of cerebral resistance arteries. Moreno-Domínguez, A., El-Yazbi, A. F., Zhu, H-L., Colinas, O., Zhong, X. Z., Walsh, E. J., Cole, D. M., Kargacin, G. J., Walsh, M. P. and Cole, W. C. (2014) J. Biol. Chem. 289: 20939-20952. Cytoskeletal reorganization evoked by Rho-associated kinase- and protein kinase C-catalyzed phosphorylation of cofilin and heat shock protein 27, respectively, contributes to myogenic constriction of rat cerebral arteries. Takeya, K., Wang, X., Sutherland, C., Kathol, I., Loutzenhiser, K., Loutzenhiser, R. D. and Walsh, M. P. (2014) J. Smooth Muscle Res. 50: 18-28. The involvement of myosin regulatory light chain diphosphorylation in sustained vasoconstriction under pathophysiological conditions. Takeya, K., Wang, X., Kathol, I., Loutzenhiser, K., Loutzenhiser, R. and Walsh, M. P. (2015)Kidney Int. 87: 370-381. Endothelin-1, but not angiotensin II, induces afferent arteriolar myosin diphosphorylation as a potential contributor to prolonged vasoconstriction. Gui, Y., Shi, Z., Wang, Z., Li, J.-J., Xu, C., Tian, R., Song, X., Walsh, M. P., Li, D., Gao, J. and Zheng, X.-L. (2015) J. Cell. Physiol. 230: 885-895. The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER. Deng, J.-T., Wang, X.-L., Chen, Y.-X., O’Brien, E. R., Gui, Y. and Walsh, M. P. (2015) PLoS ONE10(2): e0116969. doi:10.1371/journal.pone.0116969. The effects of knockdown of Rho-associated kinase 1 and zipper-interacting protein kinase on gene expression and function in cultured human arterial smooth muscle cells. Mills, R. D., Mita, M., Nakagawa, J., Shoji, M., Sutherland, C. and Walsh, M. P. (2015) J. Biol. Chem. 290: 8677-8692. A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle. [Selected Paper of the Week]. Zhou, Y.-X., Shi, Z., Singh, P., Yin, H., Yu, Y.-N., Li, L., Walsh, M. P., Gui, Y. and Zheng, X.-L. (2015) J. Cell. Physiol. 231: 393-402. Potential role of glycogen synthase kinase-3β in regulation of myocardin activity in human vascular smooth muscle cells. Hong, F., Brizendine, R. K., Carter, M. S., Alcala, D. B., Brown, A. E., Chattin, A. M., Haldeman, B. D., Walsh, M. P., Facemyer, K. C., Baker, J. E. and Cremo, C. R. (2015) J. Gen. Physiol. 146:267-280. Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle.