个人简介

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)

研究领域

Cell Signalling and Structure Genomics Proteomics and Bioinformatics Molecular Biology and Disease

The Riabowol Laboratory studies the mechanisms that are critical for enforcing the state of cellular senescence in normal human cells to determine how these mechanisms are eluded during the process of cancer cell immortalization. We examine the roles of tumour suppressors and transcription factors in these processes and we discovered a novel tumour suppressor we called ING1 for INhibitor of Growth that is intimately involved in cell aging and immortalization. The ING gene family encodes a family of proteins produced by alternative splicing that contain PHD domains and these proteins regulate apoptosis through their ability to transduce phospholipid-mediated stress signals resulting from DNA damage. The ING proteins are also regulators of histone acetyltransferases (HATs) and histone deacetylases (HDACs) that regulate chromatin structure and gene expression and a number of knockout models in different experimental systems are being developed to examine the contribution of ING proteins to cell development and aging.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Boyko, A and Riabowol, K. Defining the minimal peptide sequence of the ING1b tumor suppressor capable of efficiently inducing apoptosis. In press, Cell Death & Disease News & Views (2015). Boyko, A and Riabowol, K. Defining the minimal peptide sequence of the ING1b tumor suppressor capable of efficiently inducing apoptosis. In press, Cell Death Discovery (2015). Rajarajacholan, UK and Riabowol, K. Aging with ING: A Comparative Study of Different Forms of Stress Induced Premature Senescence. Oncotarget Online ISSN: 1949-2553 (2015). Thakur, S., Nabbi, A., Klimowicz, A., Riabowol, K. Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival. Molecular Cancer 14:164 (2015). Nabbi, A. and Riabowol, K. Isolation of Nuclei from Cells in Vitro. in Subcellular Fractionation: a Laboratory Manual, Cold Spring Harbor Laboratory press, Cold Spring Harbor, NY pp211-219 (2015). Nabbi, A., Almami, A., Thakur, S., Suzuki, K, Boland, D., Bismar, T., Riabowol, K. ING3 protein expression in normal human tissues suggests roles in growth and self-renewal. European Journal of Cell Biology 94:214-222 (2015). Tran, UM., Rajarajacholan, U., Soh, J., Kim, T-S., Thalippilly, S., Sensen, CW. and Riabowol, K. LincRNA-p21 acts as a mediator of ING1b-induced apoptosis. Cell Death & Disease 6:e1668 (2015). Thakur, S., Singla, A., Tran, U., Chen, J., Yang, Y, Jirik, F., Magliocco, A., Klimowicz, A., Riabowol, K. Reduced ING1 levels in brfeast cancer promotes metastasis. Oncotarget 5: 4244-4256 (2014). Bose, P., Thakur, SS., Brockton, NT., Klimowicz, AC., Kornaga, E., Nakoneshny, SC., Riabowol, KT., Dort, JC. Tumor cell apoptosis mediated by cytoplasmic ING1 is associated with improved survival in oral squamous cell carcinoma patients. Oncotarget 5: 3210-3219 (2014). Satpathy, S., Guérillon, C., Kim, T-S., Bigot, N., Thakur, S., Bonni, S., Riabowol, K. and Pedeux, R. PIAS4-dependent SUMOylation of ING1 contributes to ING1-mediated gene repression.Carcinogenesis 35: 2214-2223 (2014). Tallen, G. and Riabowol, K. Keep-ING balance: Tumor suppression by epigenetic regulation.FEBS Letters 588: 2728-2742 (2014). Gardner, M., Bann, D., Wiley, L., Cooper, R., Hardy, R., Nitsch, D., Martin-Ruiz, C., Shiels, P., Aihie Sayer, A., Barbieri, M., Claus Bischoff, Angela Brooks-Wilson, Richard Cawthon, Wei Chen, Cyrus Cooper, Kaare Christensen, Tim De Meyer, Ian Deary, Geoff Der, Ana Diez Roux, Annette Fitzpatrick, Christine Garcia, Anjum Hajat, Julius Halaschek-Wiener, Sarah Harris, Steven Hunt, Carol Jagger, Robert Kaplan, Masayuki Kimura, Peter Lansdorp, Changyong Li, Toyoki Maeda, Massimo Mangino, Tim Nawrot, Peter Nilsson, Katarina Nordfjall, Karl Riabowol, Tony Robertson, Goran Roos, Jan Staessen, Tim Spector, Brad Unryn, Pim van der Harst, Jean Woo, Chao Xing, Mohammad Yadegarfar, Jae Yong Park, Neal Young, Diana Kuh, Thomas von Zglinicki, Yoav Ben-Shlomo and the Halcyon study team. Gender and telomere length: systematic review and meta-analysis. Exp. Gerontology 51:15-27 (2014). Bose, P., Thakur, S., Thalappilly, S., Ahn, B-Y., Satpathy, S., Feng, X., Suzuki, K., Kim, S-W. andRiabowol, K. ING1 induces apoptosis through direct effects at the mitochondria. Cell Death & Disease Oct 3;4:e837. doi: 10.1038/cddis.2013.398 (2013). Yu, L., Thakur, S., Leong-Quong, R.Y.Y., Suzuki, K., Pang, A., Bjorge, JD, Riabowol, K. and Fujita,DJ. Src regulates the activity of the ING1 tumor suppressor. PLoS One 8(4):e60943 (2013). Rajarajacholan, U., Thalappilly, S. and Riabowol, K. The ING1a tumour suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. PLoS Biology11(3):e1001502 (2013). This report was featured in the Research Highlights section of Nature Reviews Cancer: 28 March, 2013 | doi:10.1038/nrc3511(http://www.nature.com/nrc/journal/v13/n5/full/nrc3511.html?WT.ec_id=NRC-201305). Chen, J., Tran, U., Rajarajacholan, UK., Thalappilly, S. and Riabowol, K. ING1b-inducible microRNA203 inhibits cell proliferation. British J. Cancer 108:1143-1148 (2013).