个人简介

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)

研究领域

Molecular and Development Genetics

The focus of my laboratory is understanding the molecular basis of lineage-specific gene expression. How does one particular cell know that it will produce an intestinal cell, for example, and not a muscle or a neuron? The experimental system on which we work and which we have been developing for the past dozen years is the development of the intestine in the simple nematode Caenorhabditis elegans. This is a wonderfully simple lineage because the entire intestine derives from a single cell in the 8-celled embryo. The aim is to understand what transcription factors and what transcription factor cascades operate within the developing intestine, in order to turn on the genes that encode the structural proteins and enzymes that allow the intestine to function. Representative phenotype of the mutant strain isolated in a screen for genes involved in gut development and differentiation. The homozygous mutant displays a gut specific defect that results in an obstructed lumen. The top figure show Nomarski optics of the mutant worm and the bottom shows the build-up of fluorescent beads in the anterior portion of the intestine.

近期论文

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Chik, J.K., Schriemer D.C., Childs, S. J. and McGhee, J.D. (2011) Proteome of the Caenorhabditis elegans Oocyte. J. Proteome Research. 10, 2300-2305. Tonsaker, T., Pratt, R. M. and McGhee, J.D. (2012) Re-evaluating the Role of ELT-3 in a GATA Transcription Factor Circuit Proposed to Guide Aging in C. elegans. Mechanisms of Aging and Development. 133, 50-53. McGhee, J.D. (2012) Reply to the letter from Drs. Kim, Budovskaya and Johnson. Mechanisms of Aging and Development. 133, 57-58. Hoegg, M.B., Robbins, S.M. and McGhee, J.D. (2012) Characterization of the C. elegans erlin homologue. BMC Cell Biology. 13(2). (http://www.biomedcentral.com/1471-2121/13/2) McGhee, J.D. (2012) The Caenorhabditis elegans intestine. Wiley Interdisciplinary Reviews (WIRES) Developmental Biology, doi.10.1002/wdev.93 McGhee, J.D. (2013) Reply to the second letter from Drs. Kim, Budovskaya and Johnson. Mechanisms of Aging and Development. 134, 66-67. Gu, S.G., Goszczynski, B., McGhee, J.D. and Fire A.Z. (in press) Unusual DNA packaging characteristics in endo-reduplicated C. elegans oocytes defined by in vivo accessibility to an endogenous nuclease activity.Epigenetics and Chromatin