个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Cell Biology, Molecular Biology, Biochemistry

I am engaged in a number of research initiatives with a primary focus on understanding the molecular mechanisms of chaperones in synaptic transmission (information transfer in the central nervous system). Recently, remarkable strides have been made in elucidating molecular chaperones, the cellular machinery whose function is to ensure that proteins achieve and maintain their (functional) conformations. The chaperone machinery maintains the correct balance between efficient and complete folding of proteins with the degradation of misfolded species. Since chaperones normally prevent the accumulation of misfolded proteins, the appearance of protein aggregates in the brain in neurodegenerative disorders (eg prion disease, Alzheimer's disease, Huntington's disease, Parkinson's disease) implies an underlying incapacity in the chaperone machinery. I want to understand how chaperones are involved in normal neural function and what role they play in neurodegenerative disorders. Key words describing research: chaperones, CSP, Hsp40, J proteins, synaptic function, protein aggregates

近期论文

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Donnelier, J. Braun, S.T., Dolzhanskaya, N., Ahrendt, E. Braun, A.P., Velinov, M., Braun, J.E. (2015) Increased Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel in Adult-Onset Neuronal Ceroid Lipofuscinosis. PLoS ONE 10(4): e0125205. Koutras C, Braun J.E.A., (2014) J protein mutations and resulting proteostasis collapse. Front. Cell. Neuroscience 10:3389 (00191) . Donnelier J, Braun J.E.A. (2014) CSPα-chaperoning presynaptic proteins. Front Cell Neurosci. Apr 29;8:116. eCollection 2014. Front Cell Neuroscience 8:3389 (00116). Ahrendt E., Kyle B.D., Braun A.P., Braun J.E.A. (2014) Cysteine String Protein Limits Expression of the Large Conductance, Calcium-activated K(+) (BK) Channel. PLoS One 10.1371 :e86586. Kyle B.D., Ahrendt E., Braun A.P., Braun J.E.A. (2013) The Large Conductance, Calcium-activated K(+) (BK) Channel is regulated by Cysteine String Protein. Sci Rep. 08:3:2447 Carnini A., Scott L.O., Ahrendt E., Proft J., Winkfein R.J., Kim S.W., Colicos M.A., Braun J.E.A. (2012) Cell line specific modulation of extracellular Aβ42 by Hsp40. PLoS One. 7(5):e37755. Elwi A.N., Lee B., Meijndert H.C., Braun J.E.A., Kim S.W. (2012) Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation. Int J Biochem Cell Biol. Aug;44(8):1366-76. Proft J., Faraji J., Robbins J.C., Zucchi F.C., Zhao X., Metz G.A., Braun J.E.A. (2011) Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease. PLoS One. 6(10):e26045. Ahrendt E., Braun J.E.A. (2010) Channel triage: Emerging insights into the processing and quality control of hERG potassium channels by DnaJA proteins 1, 2 and 4. Channels (Austin). Sep-Oct;4(5):335-6. Xu F., Proft J., Gibbs S., Winkfein B., Johnson J.N., Syed N., Braun J.E.A. (2010) Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission. PloS One 5(6):e 11045 Johnson, J.N., Ahrendt, E., Braun, J.E.A. (2010) CSPα: the neuroprotective J protein. Biochemistry and Cell Biology 88(2) 157-165 Carnini, A., Casha, S., Yong, V.W., Hurlbert, R.J., Braun, J.E.A. (2010) Reduction of PrPC in human cerebrospinal fluid after spinal cord injury. Prion 4(2). Weng, N., Baumler, M., Thomas, D.D.H., Swayne, L.A., Braun, J.E.A., Groblewski, G.E.(2009) Funtional Role of Cysteine String Protein's J Domain in Ca2+-Dependent Secretion from Acinar Cells. Am J. Phys. 265 (5) :G1030-1039. Gibbs, S., Barren, B., Beck, K.E., Proft, J., Zhao, X., Noskova, T., A., Braun, A.P., Artemyev, N.O., Braun J.E.A. (2009) Hsp40 Transiently Assembles with the CSPα Chaperon Complex upon induction of the heat shock response. PLOS ONE 4(2):E4595 Rosales-Hernandez, A., Beck, K.E., Zhao, X., Braun, A.P., Braun, J.E.A. (2009) Rdj2 (DnaJA2) Chaperones Neural G Protein Signalling Pathways. Cell Stress & Chaperones.14:71-82 Gibbs, S.J. Braun, J.E.A. (2008) Emerging Roles of J Proteins in Neurodegenerative Disorders. Neurobiology of Disease 32 196-199. Zhao, X., Braun, A.P., Braun, J.E.A. (2008) Biological Roles of Neural J proteins. Cellular and Molecular Life Sciences Aug;65(15):2385-96. Sheng, J.-Z., Arshad, F., Braun, J.E.A., Braun, A. (2008) Estrogen and the Ca-mobilizing Agonist ATP Evoke Acute Nitric Oxide Synthesis via Distinct Pathways in an Individual Human Vascular Endothelial Cell. American Journal of Physiology Vol. 294no. C1531-C1541. Swayne, L.A. Braun, J.E.A. (2007) Aggregate-centered redistribution of proteins by mutant huntingtin. Biochemical Biophysical Research Communications. 354: 39-44. Bai, L., Swayne, L.A., Braun, J.E.A. (2007) The CSPα/G protein complex in PC12 cells. Biochemical Biophysical Research Communications. 352(1): 123-129.