个人简介

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)

研究领域

Molecular Biology and Disease Cell Signalling and Structure

The processes of cell proliferation and differentiation are critical in the development and homeostasis of multicellular organisms and are thus tightly regulated. We are interested in the intracellular mechanisms by which extracellular growth factors regulate these processes. The transforming growth factor-bs (TGF-b) superfamily of secreted polypeptides including, the TGF-bs, activins and BMPs regulate such diverse biological responses as apoptosis, proliferation and differentiation in the developing and adult organism. Inhibition of cell proliferation is a widely studied TGF-b response. Moreover, loss of TGF-b inhibition of cell proliferation is often observed in tumor cells and may contribute to the pathogenesis of a variety of epithelial tumors such as colorectal carcinomas. The importance of these growth factors during development and disease has therefore sparked a great deal of interest in understanding the intracellular mechanisms of TGF-b responses. Although progress has been made, these mechanisms remain incompletely understood. Our research interests are to elucidate the intracellular mechanisms by which the TGF-b proteins regulate cell proliferation and differentiation. To achieve our objective, our research involves the use of various cell biology, molecular biology and biochemical techniques. Our work should provide important insight into the intracellular mechanisms of TGF-b responses and its role in tumor.

近期论文

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Huynh, M.A., Ikeuchi, Y., Netherton, S., Torre-Ubeita, L. Kanadia, R., Stegmuller, J., Cepko, C.,Bonni, S., Bonni, A. (2011) An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. March 10; 69(5):930-44 Pot, I., Ikeuchi, Y., Bonni A., Bonni, S. (2010) SnoN: Bridging Neurobiology and Cancer Biology.Curr. Mol. Med. 10 (7):667-73 Netherton, S. J., Bonni, S. (2010) Suppression of TGFβ-induced epithelial-mesenchymal transition like phenotype by a PIAS1 regulated sumoylation pathway in NMuMG epithelial cells.PLoS ONE Nov 12;5 (11): e13971 - Evaluated by F1000. Ikeuchi, Y. Stegmüller, Netherton, S. , J. Huynh, M.A., Masu, M., Frank, D., Bonni, S. , Bonni, A. (2009) A SnoN-Ccd1 Pathway Promotes Axonal Morphogenesis in the Mammalian Brain. J. Neurosci. 29:4312-21 Sarker, K.P., Kataoka, H., Chan, A., Netherton, S., Pot, I., Huynh, M.A., Feng, X., Bonni, A., Riabowol, K., and Bonni, S. (2008) ING2 as a Novel Mediator of TGF-β-Dependent Responses in Epithelial Cells. J. Biol. Chem. 283:13269-79. Pot, I. and Bonni, S. (2008) SnoN in TGFβ Signaling and Cancer Biology. Curr. Mol. Med. 8:319-28. Invited Review