个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Genomics Proteomics and Bioinformatics

Microarrays are a miniaturized, ordered arrangement of nucleic acid fragments representative of individual genes, enabling the study of thousands of genes in parallel. They are being used extensively to generate comprehensive data on gene expression patterns in a wide variety of tissues, under different experimental conditions and contexts, to uncover new groups of genes, and to reveal new molecular mechanisms underlying these patterns. I am interested in the development of this technology from the perspective of the design of experiments (and arrays) that exploit its innate strengths while addressing weaknesses that have been observed by researchers in the field. As Manager of SAMF, I am interested in optimizing protocols for production, interrogation, and analysis of microarrays. My basic science interest is in Wilms tumor, an embryonal cancer of the kidney that is diagnosed in approximately 8 children per million per year, making it the second most common malignant abdominal tumor in childhood. Through the combined efforts of the National Wilms Tumor Study Group and the International Society of Paediatric Oncology, and clinicians and other health professionals, scientists, patients and their families, the long-term survival of children with Wilms tumor now exceeds 85%. Notwithstanding these advancements, 10-15% of patients suffer relapse. Thus, children with histo-pathologically identical tumors can have very different outcomes, suggesting a difference in these tumors that may not be detectable under the microscope, but is nevertheless there. If known, this would help to identify patients at risk, whose treatment regimens could be adjusted accordingly. My research in Wilms tumor focuses on using microarrays to uncover differences between tumors of dissimilar outcomes at the level of gene expression. For these studies, we use the human 14k microarray produced at the Southern Alberta Microarray Facility.

近期论文

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Arcellana-Panlilio, M., and Robbins, S. M. (2002). Cutting-edge technology. I. Global gene expression profiling using DNA microarrays. Am J Physiol Gastrointest Liver Physiol 282, G397-402. Arcellana-Panlilio, M., Ujack, E., Robbins, S. M., and Coppes, M. J. (2002a). Differential expression profiles of relapse in favorable histology Wilms tumour. Paper presented at: UKCCSG Biology of Childhood Cancer Annual Meeting (London, England). Arcellana-Panlilio, M., Ujack, E., Robbins, S. M., and Coppes, M. J. (2003). Differential expression profiles of relapse in favorable histology Wilms tumor. Paper presented at: International Society of Paediatric Oncology - SIOP XXXV (Cairo, Egypt, Wiley-Liss). Arcellana-Panlilio, M., Ujack, E., Wang, X., Robbins, S. M., and Coppes, M. J. (2002b). Molecular characterization of relapse in Wilms tumor. Paper presented at: 7th World Congress on Advances in Oncology and 5th International Symposium on Molecular Medicine (Hersonissos, Crete, Greece.).