Wildering, Willem Carel - University of Calgary - Department of Biological Sciences

个人简介

PhD - Neuroscience Vrije Universitéit, 1992 MS - Physiology and Pharmacology University of Groningen, 1986

研究领域

Cellular and molecular mechanisms of neuronal aging and neurodegeneration Neurotoxicology of aquatic pollutants

近期论文

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Hermann PM, Watson SN and Wildering WC (2014). Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability and functional declineof the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment. Frontiers in Genetics, Genetics of Aging, 5:419. Watson SN, Lee JR, Risling TE, Hermann PM and Wildering WC (2013) Decreased GSH availability is a factor in the innate age-associated decline in neuronal electrical excitability in a gastropod model of neuronal aging. Neurobiol Aging. Hermann PM, Park D, Beaulieu E, and Wildering WC. (2013) Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2 and COX inhibitors abolish long-term memory failure induced by systemic immune challenges. BMC Neuroscience 14: 83. Watson, S.N. Risling, T.E., Hermann, P.M. and Wildering, W.C. (2012) Failure of delayed nonsynaptic neuronal plasticity underlies age-associated long-term associative memory impairment. BMC Neuroscience 13:103. Watson, S.N., Wright, N., Hermann, P.M. and Wildering, W.C. (2013) Phospholipase A2: The key to learning and memory deficiencies in the normal aging brain. Neurobiol Aging 34(2): 610-620. E-pub ahead of print Mar 28, 2012. Watson, S.N., Nelson, M.A. and Wildering, W.C. (2012) Redox agents modulate neuronal activity and reproduce physiological aspects of neuronal aging. Neurobiol Aging 33(1): 149-161. E-pub ahead of print Feb 12, 2010. Feng, Z.-P., Zhang, Z., van Kesteren, R.E., Straub, V., van Nierop, P., Jin, K., Nejatbakhsh, N., Goldberg, J., Spencer, G., Yeoman, M., Wildering, W., Coorssen, J.R., Croll, R., Buck, L., Syed, N.I., Smit, A.B. (2009) Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis. BMC Genomics 23(10):451. Hermann, P.M. Genereux, B. and Wildering, W.C. (2009) Evidence for age-dependent mating strategies in the simultaneous hermaphrodite snail, Lymnaea stagnalis (L.). J. Exp. Biol. 212: 3164-3173. Liu W-Q, Martinez JA., Durand, J, Wildering WC, Zochodne DW (2008) RGD-mediated adhesive interactions are important for peripheral axon outgrowth in vivo. Neurobiology of Disease 34(1):11-22. Epub 2008 Dec. Wildering, W.C. (2008). Electrical synapses. In. Encyclopedia of Neuroscience. Binder MD, Hirokawa N, Windhorst U. Hirsch MC (eds). Springer-Verlag Hermann PM, Nicol JJ, Bulloch, AGM, Wildering WC. (2008) RGD-dependent mechanisms in the endoneurial phagocyte response and axonal regeneration in the nervous system of the snail Lymnaea stagnalis J Exp Biol 211: 491-501. Hermann PM, Lee A, Hulliger S, Minvielle M, Ma B, Wildering WC (2007) Impairment of long-term associative memory in aging snails (Lymnaea stagnalis). Behav. Neurosci. 121(6):1400-1414. Hermann PM, Nicol JJ, Nagle GT, Bulloch AGM, Wildering WC. (2005) Epidermal growth factor dependent enhancement of axonal regeneration in the pond snail Lymnaea stagnalis: Role of phagocyte survival. J Comp Neurol. J Comp Neurol. 492(4):383-400. Pollock NS, Atkinson-Leadbeater K, Johnston J, Larouche M, Wildering WC, McFarlane S. (2005) Voltage-gated potassium channels regulate the response of retinal growth cones to axon extension and guidance cues. Eur J Neurosci. 22(3):569-578. Hermann PM, Schein CH, Nagle GT, Wildering WC. (2004) Lymnaea EGF and Gigantoxin I, novel invertebrate members of the epidermal growth factor family. Curr Pharm Design 10(31): 3885-3892. Wildering WC, Hermann PM, Bulloch AGM. (2002) Rapid neuromodulatory actions of integrin ligands. J Neurosci 22(7): 2419-2426.Wildering WC, Hermann PM, Bulloch AGM. (2001). Lymnaea epidermal growth factor promotes axonal regeneration. J Neurosci 21(23): 9345-9354. Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno J, Smit JS, Kumar SB, Geraerts WPM, Ericsson LH, Smit AB, Bulloch AGM, Nagle GT. (2000) Neurotrophic actions of a novel molluscan epidermal growth factor. J Neurosci 20(17): 6355-6364. Hermann PM, Wildering WC, Bulloch AGM. (2000) Functional recovery of respiratory behavior during axonal regeneration in snails (Lymnaea stagnalis) is experience dependent. Behav Neurosci 114(2): 410-423. Wildering, W.C., Hermann, P.M. and Bulloch, A.G.M. (1998) Neurite outgrowth, RGD-dependent, and RGD-independent adhesion of identified molluscan motoneurons on selected substrates. J. Neurobiol. 35(1): 37-52. Hermann PM, Lukowiak K, Wildering WC, Bulloch AGM. (1997) Pronase acutely modifies HVA Ca2+ current and integrative properties of Lymnaea neurons. Eur J Neurosci 9(12): 2624-2633.