VOGEL, HANS J. - University of Calgary - Department of Biochemistry & Molecular Biology

研究领域

1) Protein-protein interactions of regulatory calcium-binding proteins in mammals and plants are studied by NMR spectroscopy and biophysical methods. 2) Structural and dynamic studies of bacterial iron uptake and fatty acid biosynthesis as potential targets for the development of new classes of antibiotics. 3) Mechanism of action of antimicrobial peptides and host defense proteins. Development of novel peptide- or protein-based bactericidal and bacteriostatic compounds. 4) Metabolomics studies of infectious and inflammatory diseases; studies of antibiotic action and sepsis in animal models and humans.

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Chan, D.I., Tieleman, D.P. and Vogel, H.J. (2010) "Molecular dynamics studies of beta-ketoacyl, beta-hydroxyacyl and trans-2-enoyl Acyl Carrier Protein of Escherichia coli" Biochemistry 49: 2860-2868. Otten, R., Chu, B., Krewulak, K.D., Vogel, H.J. and Mulder, F.A.A. (2010) "Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins" J. Am. Chem. Soc. 132: 2952-2960. Nguyen L.T., Chan, I.D., Boszhard, L., Zaat, S.A.J. and Vogel, H.J. (2010) "Structures and antimicrobial activities of chemokine-derived carboxy-terminal helical peptides" Biochem. Biophys. Acta - Biomembranes 1798: 1062-1072. Haney, E.F. and Vogel, H.J. (2009) "NMR studies of antimicrobial peptides" Annu. Reports NMR Spectroscopy 65:1-51. Yamniuk, A.P., Ishida, H., Lippert, D., and Vogel, H.J. (2009). "Thermodynamic effects of non-coded and coded methionine-substitutions in calmodulin" Biophys. J. 96: 1495-1507. Lopez, C.S., Peacock, R.S., Crosa, J.H. and Vogel, H.J. (2009). "Molecular characterization of TonB2 from the fish pathogen Vibrio anguilarum" Biochem J. 418: 49-59. Wishart, D.S., Knox, C., 25 coauthors, Nazyrova, A, Shaykhutdinov, R, Li, L. and Vogel, H.J. and Forsythe, I. (2009) "HMDB: a knowledgebase for the human metabolome" Nucleic Acids Res. 37: D603-D610. Pushie, M.J., Rauk, A., Jirik, F. and Vogel, H.J. (2009) "Can copper binding to the prion protein generate a misfolded form of the protein?" Biometals 22: 159-175. Yamniuk, A.P., Burling, H. and Vogel, H.J. (2009). "Thermodynamic characterization of the interactions between osteopontin and lactoferrin" Mol. Immunol. 46: 2395-2402. Ishida, H, Rainaldi, M. and Vogel, H.J. (2009) "Structural analysis of soybean calmodulin isoform-4 complexed with MAPK-phosphatase-1 provides insight into a unique sequential target-binding mode" J. Biol. Chem. 284: 28292-28305. Llamas, M.A., vanderSar, A., Chu, B.C., Sparrius, M., Vogel, H.J. and Bitter, W. (2009) "A novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa" Plos Pathog. 5 (9): e1000572. Yamniuk, A.P., Gifford, J.L., Linse, S. and Vogel, H.J. (2008). "The effects of metal binding loop mutations on ligand-binding to the calcium- and integrin-binding protein 1: Evolution of the EF-hand?" Biochemistry 47: 1696-1707. Chan, D.I., Hunter, H.N., Tack, B.F. and Vogel, H.J. (2008). "Human macrophage inflammatory protein 3alpha: solution structure, dimerization and anti-infective properties" Antimicrob. Agents Chemother. 52: 883-894. Ishida, H., Huang, H., Yamniuk, A.P., Takaya, Y. and Vogel, H.J. (2008). "The solution structures of two soybean calmodulin isoforms and their relationship to selective target-activation properties" J. Biol. Chem. 283: 14619-14628. Ishida, H., Borman, M.A., Ostrander, J., Vogel, H.J. and MacDonald, J.A. (2008). "Solution structure of the calponin homology (CH)-domain from smoothelin-like 1 protein: a unique apo-calmodulin binding mode" J. Biol. Chem. 283: 20569-20578. Pushie, M.J. and Vogel, H.J. (2008). "Modeling by assembly and molecular dynamics of the low Cu2+ occupancy form of the mammalian prion protein octarepeat region: gaining insight into Cu2+-mediated beta-cleavage" Biophys. J. 95: 5084-5091. Chan, D.I., Stockner, T., Tieleman, D.P., and Vogel, H.J. (2008). "Molecular dynamics simulations of apo-, holo- and acyl- forms of Escherichia coli acyl carrier protein" J. Biol. Chem. 283: 33620-33629. Weljie, A.M., Newton, J., Jirik, F.R. and Vogel, H.J. (2008). "Incorporating signals of unknown compounds in quantitative mixture analysis" Anal. Chem. 80: 8956-8965.

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