Syme, Douglas - University of Calgary - Department of Biological Sciences

个人简介

PhD - Ecology and Evolutionary Biology University of California at Irvine, 1993 MSc - Physiology University of Guelph, 1989 BSc - Zoology University of Guelph, 1987

研究领域

muscle physiology (whole muscle to subcellular) animal locomotion energetics of contraction and movement comparative cardiovascular physiology My interests lie in comparative muscle physiology, animal locomotion, and comparative cardiovascular physiology. Muscles come in many designs and are used in diverse fashions. Most vertebrates and many invertebrates possess different cell types within a single muscle, ranging from those that shorten very fast to very slow, and having varying degrees of fatigueability, preferred energy substrate, twitch speed, power output, etc. It is believed this blend allows a single muscle to perform in different ways depending on the task at hand. We study the mechanical performance of muscle, how designs at the cellular level translate into performance, and how the structures through which muscles transmit energy (e.g. tendons) impact the ability of muscles to do work and ultimately produce movement. Current projects include: how stretch of muscle impacts subsequent contractions, force production and work output; how various types of contractions impact the energy used by muscles and subsequently the efficiency of muscle contraction; how muscles are recruited during swimming in fish to produce thrust and control movement; the effects of temperature on muscle contraction and control of movement; modeling and empirical studies of the effects of tendon compliance on muscle performance. We have ongoing collaborative projects in areas of tuna and shark muscle physiology, swimming biomechanics and cardiovascular function in fishes with national and international collaborators.

近期论文

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D.G. McGillivray, T. Garland, Jr., E.M. Dlugosz, M.A. Chappell, and D.A. Syme. 2009. Changes in efficiency and myosin expression in the small-muscle phenotype of mice selectively bred for high voluntary running activity. J. Exp. Biol. 212, 977-985. Shadwick, R.E. and Syme, D.A. 2008. Thunniform swimming: muscle dynamics and mechanical power production of aerobic fibres in yellowfin tuna (Thunnus albacares). J. Exp. Biol. 211, 1603-1611. Syme, D.A., Gollock, M., Freeman, M.J., Gamperl, A.. 2008. Power isn’t everything: muscle function and energetic costs during steady swimming in Atlantic cod (Gadus morhua). Physiol. Biochem. Zool. 81(3): 320–335. Trinh, M. and Syme, D.A. 2007. Effects of stretch on work and efficiency of frog (Rana pipiens) muscle. J. Exp. Biol. 210, 2843-2850. Donley, J.M., Shadwick, R.E., Sepulveda, C.A. and Syme, D.A. 2007. Thermal dependence of contractile properties of the aerobic locomotor muscle in the leopard shark and shortfin mako shark. J. Exp. Biol. 210: 1194-1203. Syme, D.A. 2006. Functional Properties of Skeletal Muscle. In Fish Physiology: Fish Biomechanics, vol 23. pp 179-240. Eds. R.E. Shadwick and G.V. Lauder, series Eds. D.J. Randall and A.P. Farrell. Academic Press, Elsevier. Syme, D.A., A.K. Gamperl, M.H. Braun and D.R. Jones. 2006. Wave reflection effects in the central circulation of American alligators (Alligator mississippiensis): what the heart sees. Am. J. Physiol. Heart Circ. Physiol. 291: H1670-1678. Bernal, D., J.M. Donley, R.E. Shadwick and D.A. Syme. 2005. Mammal-like muscles power swimming in a cold-water shark. Nature. 437: 1349-1352. Syme, D.A., K. Evashuk, B. Grintuch, E.L. Rezende, and T. Garland, Jr. 2005. Contractile abilities of normal and “mini” triceps surae muscles from mice (Mus domesticus) selectively bred for high voluntary wheel running. J. Appl. Physiol. 99: 1308-1316. Syme, D.A. and Tonks, D.M. 2004. Fatigue and recovery of dynamic and steady-state performance in frog skeletal muscle. Am J. Physiol. 286, R916-926. Syme, D.A. and R.E. Shadwick. 2002. Effects of longitudinal body position and swimming speed on mechanical power of deep red muscle from skipjack tuna (Katsuwonus pelamis). J. Exp. Biol. 205(2). 189-200. Syme, D.A., A.K. Gamperl & D.R. Jones. 2002. Delayed depolarization of the cog-wheel valve and pulmonary-to-systemic shunting in alligators. J. Exp. Biol. 205: 1843-1851. Syme, D.A. & M.J. Grattan. 2002. Effects of stretch on work from fast and slow muscles of mice: damped and undamped energy release. Can. J. Physiol. Pharmacol. 80: 887-900. Wakeling, J. & D.A. Syme. 2002. Wave properties of action potentials from fast and slow motor units of rats. Muscle Nerve. 26:659-668. Katz, S.L., D.A. Syme & R.E. Shadwick. 2001. High-speed swimming: Enhanced power in yellowfin tuna. Nature. 12 April, vol 410: 770-771. Rome, L.C., C. Cook, D.A. Syme, M.A. Connaughton, M. Ashley-Ross, A. Klimov, B. Tikunov & Y.E. Goldman. 1999. Trading force for speed: why superfast cross-bridge kinetics leads to super low forces. Proc. Nat. Acad. Sci. USA. May 11, 96(10):5826-31. Rome, L.C., D.A. Syme, S. Hollingworth, S.L. Lindstedt & S.H. Baylor. 1996, July 23. The whistle and the rattle: the design of sound producing muscles. Proc. Nat. Acad. Sci. USA. 93(15): 8095-8100. Syme, D.A., & R.K. Josephson. 1995. Influence of muscle length on work from trabecular muscle of frog atrium and ventricle. J. Exp. Biol. 198: 2221-2227. Johnson, T.P., D.A. Syme, B.C. Jayne, G.V. Lauder, & A.F. Bennett. 1994. Modeling red muscle power output during steady and unsteady swimming in largemouth bass. Am. J. Physiol. 267: R481-488. Syme, D.A. 1994. The efficiency of frog ventricular muscle. J. Exp. Biol. 197: 143-164.