个人简介

Queen Elizabeth II Diamond Jubilee Medal (The Governor General of Canada), 2012 Leo Yaffe Award for Excellence in Teaching (McGill), 2011-12 David Thomson Award in Graduate & Teaching (McGill), 2010 Fessenden Professorship in Science Innovation (McGill), 2010 Bernard Belleau Award (CSC/CIC), 2007 Merck-Frosst Award for Therapeutic Research (CSC/CIC), 1999 Fellow of the Chemical Institute of Canada (FCIC), since 1999 The John Charles Polanyi Chemistry Prize, 1989

研究领域

Chemical Biology Synthesis/Catalysis

Our group is interested in the synthesis, biochemical properties and molecular behavior of nucleic acids (DNA, RNA) and their analogues. A goal of this research endeavor is to gain a detailed understanding of inter- and intracellular communication between nucleic acids, and between nucleic acids and proteins. Many of our projects are chosen because of their potential impact on biotechnology.

近期论文

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Synthesis and Properties of 2'-Deoxy-2',4'-difluoroarabinose-Modified Nucleic Acids. Martínez-Montero S, Deleavey GF, Dierker-Viik A, Lindovska P, Ilina T, Portella G, Orozco M, Parniak MA, González C, Damha MJ. J Org Chem. 2015 Mar 20;80(6):3083-91. doi: 10.1021/jo502948t. Epub 2015 Mar 5. PMID: 25723361. Select item 25329642 An orthogonal photolabile linker for the complete "on-support" synthesis/fast deprotection/hybridization of RNA. Lietard J, Hassler MR, Fakhoury J, Damha MJ. Chem Commun (Camb). 2014 Dec 11;50(95):15063-6. doi: 10.1039/c4cc07153k. PMID: 25329642. Select item 25213224 Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography. Lietard J, Kretschy N, Sack M, Wahba AS, Somoza MM, Damha MJ. Chem Commun (Camb). 2014 Nov 4;50(85):12903-6. doi: 10.1039/c4cc05771f. PMID: 25213224. Select item 25162466 Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity. Anzahaee MY, Deleavey GF, Le PU, Fakhoury J, Petrecca K, Damha MJ. Nucleic Acid Ther. 2014 Oct;24(5):336-43. doi: 10.1089/nat.2014.0496. Epub 2014 Aug 27. PMID: 25162466. Select item 25123664 Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Montemayor EJ, Katolik A, Clark NE, Taylor AB, Schuermann JP, Combs DJ, Johnsson R, Holloway SP, Stevens SW, Damha MJ, Hart PJ. Nucleic Acids Res. 2014;42(16):10845-55. doi: 10.1093/nar/gku725. Epub 2014 Aug 14. PMID: 25123664. Select item 24919400 A homolog of lariat-debranching enzyme modulates turnover of branched RNA. Garrey SM, Katolik A, Prekeris M, Li X, York K, Bernards S, Fields S, Zhao R, Damha MJ, Hesselberth JR. RNA. 2014 Aug;20(8):1337-48. doi: 10.1261/rna.044602.114. Epub 2014 Jun 11. PMID: 24919400. Select item 24873952 Rigid 2',4'-difluororibonucleosides: synthesis, conformational analysis, and incorporation into nascent RNA by HCV polymerase. Martínez-Montero S, Deleavey GF, Kulkarni A, Martín-Pintado N, Lindovska P, Thomson M, González C, Götte M, Damha MJ. J Org Chem. 2014 Jun 20;79(12):5627-35. doi: 10.1021/jo500794v. Epub 2014 Jun 6. PMID: 24873952. Select item 24698549 An evaluation of selective deprotection conditions for the synthesis of RNA on a light labile solid support. Johnsson RA, Bogojeski JJ, Damha MJ. Bioorg Med Chem Lett. 2014 May 1;24(9):2146-9. doi: 10.1016/j.bmcl.2014.03.032. Epub 2014 Mar 20. PMID: 24698549. Select item 24401015 Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates. Katolik A, Johnsson R, Montemayor E, Lackey JG, Hart PJ, Damha MJ. J Org Chem. 2014 Feb 7;79(3):963-75. PMID: 24401015. Select item 24141773 DRR regulates AKT activation to drive brain cancer invasion. Dudley A, Sater M, Le PU, Trinh G, Sadr MS, Bergeron J, Deleavey GF, Bedell B, Damha MJ, Petrecca K. Oncogene. 2014 Oct 9;33(41):4952-60. doi: 10.1038/onc.2013.436. Epub 2013 Oct 21. PMID: 24141773