研究领域
RNA-dependent RNA Polymerases
RNA-dependent RNA polymerases are the central enzymes responsible for replicating the genomes of positive-stranded RNA viruses. Positive-stranded RNA viruses are the cause of many human diseases -- such as polio, the common cold, hepatitis A, hepatitis C, dengue fever, viral encephalitis (West Nile virus), viral gastroenteritis (Norwalk virus) and the recently discovered Severe Acute Respiratory Syndrome (SARS). Positive-stranded RNA viruses also cause many serious diseases in other animals (for example, foot-and-mouth disease, rabbit hemorrhagic disease, feline calicivirus disease, porcine respiratory and reproductive syndrome, and equine viral arteritis) and plants (for example, plum pox, barley yellow disease, potato virus Y).
Caliciviruses
Carbohydrate-binding proteins
As a part of the Alberta Ingenuity Centre for Carbohydrate Sciences (AICCS), we interact extensively with five other labs at the University of Alberta and at the University of Calgary to pursue interdisciplinary research investigating the diverse functions of carbohydrates and carbohydrate-binding proteins
Here are some of the main systems that we are currently studying:
Clostridium difficile toxins -- We are characterizing carbohydrate-binding activities in these toxins to better understand their roles in the pathogenesis of antibiotic associated diarrhea and pseudomembranous colitis
New England Journal of Medicine Editorial on highly toxigenic C. difficile strain causing recent outbreaks in Quebec and US
Canadian Medical Association Journal news item on C. difficile outbreak in Montreal and Calgary -- July 6, 2004
Canadian Medical Association Journal review on C. difficile pathogenesis & treatment -- July 6, 2004
Serum Amyloid Protein -- We are collaborating with Dave Bundle and other members of the AICCS to develop carbohydrate ligands of SAP for use in treating Alzheimer's disease
C-type lectins
近期论文
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Radiographic indices for lumbar developmental spinal stenosis.Cheung JP, Ng KK, Cheung PW, Samartzis D, Cheung KM.Scoliosis Spinal Disord. 2017 Feb 20;12:3. doi: 10.1186/s13013-017-0113-3.
Near-Infrared Activatable Phthalocyanine-Poly-L-Glutamic Acid Conjugate: Increased Cellular Uptake and Light-Dark Toxicity Ratio Towards An Effective Photodynamic Cancer Therapy.Kiew LV, Cheah HY, Voon SH, Gallon E, Movellan J, Ng KH, Alpugan S, Lee HB, Dumoulin F, Vicent MJ, Chung LY.Nanomedicine. 2017 Feb 15. pii: S1549-9634(17)30020-5. doi: 10.1016/j.nano.2017.02.002. [Epub ahead of print]
Clinical implications of reversal agents for direct oral anticoagulants.Monagle S, Eikelboom JW, Ng KH, Bhagirath VC.Future Cardiol. 2017 Mar;13(2):153-159. doi: 10.2217/fca-2016-0070.
An observational follow-up study on pelvic floor disorders to 3-5 years after delivery.Ng K, Cheung RY, Lee LL, Chung TK, Chan SS.Int Urogynecol J. 2017 Feb 14. doi: 10.1007/s00192-017-3281-z. [Epub ahead of print]
Review of first 36 cases of New Delhi metallo-β-lactamase-producing Enterobacteriaceae in Hong Kong.Lung DC, Tsang OT, Choi KW, Hung IF, Chan KM, Wu AK, Tso EY, Wu TC, Lam TS, Wong AW, Ng KH, Lui SS, Hsu EK, Wong AT.J Glob Antimicrob Resist. 2017 Feb 9. pii: S2213-7165(17)30015-2. doi: 10.1016/j.jgar.2017.01.002. [Epub ahead of print] No abstract available.
Oncogenomic disruptions in arsenic-induced carcinogenesis.Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJ, Lam WL, Martinez VD.Oncotarget. 2017 Jan 5. doi: 10.18632/oncotarget.15106. [Epub ahead of print] Review.
Drug repurposing and therapeutic anti-microRNA predictions for inhibition of oxidized low-density lipoprotein-induced vascular smooth muscle cell-associated diseases.Chen ST, Huang CH, Kok VC, Huang CF, Ciou JS, Tsai JJ, Kurubanjerdjit N, Ng KL.J Bioinform Comput Biol. 2017 Feb;15(1):1650043. doi: 10.1142/S0219720016500438.
Genomic insight into pathogenicity of dematiaceous fungus Corynespora cassiicola.Looi HK, Toh YF, Yew SM, Na SL, Tan YC, Chong PS, Khoo JS, Yee WY, Ng KP, Kuan CS.PeerJ. 2017 Jan 26;5:e2841. doi: 10.7717/peerj.2841.
Effects of intranasal oxytocin on interpretation and expression of emotions in anorexia nervosa.Leppanen J, Cardi V, Ng KW, Paloyelis Y, Stein D, Tchanturia K, Treasure J.J Neuroendocrinol. 2017 Jan 31. doi: 10.1111/jne.12458. [Epub ahead of print]
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.Yurgelun MB, Kulke MH, Fuchs CS, Allen BA, Uno H, Hornick JL, Ukaegbu CI, Brais LK, McNamara PG, Mayer RJ, Schrag D, Meyerhardt JA, Ng K, Kidd J, Singh N, Hartman AR, Wenstrup RJ, Syngal S.J Clin Oncol. 2017 Jan 30:JCO2016710012. doi: 10.1200/JCO.2016.71.0012. [Epub ahead of print]
Large-scale collection of full-length cDNA and transcriptome analysis in Hevea brasiliensis.Makita Y, Ng KK, Veera Singham G, Kawashima M, Hirakawa H, Sato S, Othman AS, Matsui M.DNA Res. 2017 Jan 27. pii: dsw056. doi: 10.1093/dnares/dsw056. [Epub ahead of print]
Recent Temporal Changes in Atherosclerotic Cardiovascular Diseases in Ontario: Clinical and Health Systems Impact.Tu JV, Khan AM, Ng K, Chu A.Can J Cardiol. 2017 Mar;33(3):378-384. doi: 10.1016/j.cjca.2016.11.009.
Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014.Oong XY, Ng KT, Tan JL, Chan KG, Kamarulzaman A, Chan YF, Sam IC, Tee KK.PLoS One. 2017 Jan 27;12(1):e0170610. doi: 10.1371/journal.pone.0170610.
Shock, Cardiac Arrest, and Resuscitation.Lin YR, Ng KC, Exadaktylos AK, Ryan JM, Wu HP.Biomed Res Int. 2017;2017:5743702. doi: 10.1155/2017/5743702. No abstract available.
'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice.Li CX, Yu B, Shi L, Geng W, Lin QB, Ling CC, Yang M, Ng KT, Huang JD, Man K.Oncol Lett. 2017 Jan;13(1):177-183. doi: 10.3892/ol.2016.5453.
Resection of T4 hepatocellular carcinomas with adjacent structures, is it justified?Chok KS, Ng KK, Cheung TT, Chan AC, Chan SC, Lo CM.Hepatobiliary Pancreat Dis Int. 2017 Feb;16(1):52-57.
Characterization of Date (Deglet Nour) Seed Free and Bound Polyphenols by High-Performance Liquid Chromatography-Mass Spectrometry.Sirisena S, Zabaras D, Ng K, Ajlouni S.J Food Sci. 2017 Feb;82(2):333-340. doi: 10.1111/1750-3841.13625.
Rosette Assay: Highly Customizable Dot-Blot for SH2 Domain Screening.Ng KY, Machida K.Methods Mol Biol. 2017;1555:437-451. doi: 10.1007/978-1-4939-6762-9_26.
De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor canadensis).Lok S, Paton TA, Wang Z, Kaur G, Walker S, Yuen RK, Sung WW, Whitney J, Buchanan JA, Trost B, Singh N, Apresto B, Chen N, Coole M, Dawson TJ, Ho K, Hu Z, Pullenayegum S, Samler K, Shipstone A, Tsoi F, Wang T, Pereira SL, Rostami P, Ryan CA, Tong AH, Ng K, Sundaravadanam Y, Simpson JT, Lim BK, Engstrom MD, Dutton CJ, Kerr KC, Franke M, Rapley W, Wintle RF, Scherer SW.G3 (Bethesda). 2017 Feb 9;7(2):755-773. doi: 10.1534/g3.116.038208.
An Overview of the Changing Landscape of Treatment for Advanced Melanoma.Lee CS, Thomas CM, Ng KE.Pharmacotherapy. 2017 Jan 4. doi: 10.1002/phar.1895. [Epub ahead of print] Review.
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