个人简介

B.Sc. (Univ. Nacional de Río Cuarto, Argentina, 1996) Ph.D. (University of Ottawa, 2002) Postdoctoral Fellow (University of Texas at Austin, 2002-2004) Asociación Química Argentina Award, 1997 Governor General’s Gold Medal Award to the best PhD Thesis, 2002 IUPAC Young Chemists Award to the best PhD Thesis in the general areas of Chemical Sciences, 2003

研究领域

Chemical Biology Synthesis/Catalysis

Understanding cellular signaling and cellular function in disease and health and developing faster diagnostics for disease detection, to name but a few of the emerging frontiers in natural sciences, demand that we improve our ability to visualize and quantify fluctuations in chemical composition, chemical interactions and macromolecular structure in the cell. Our research activities involve three main aspects of Chemical Imaging with an emphasis in fluorescence : Chemical Synthesis of Fluorescent Probes The design and chemical synthesis of Reactive Oxygen Species-sensitive fluorescent probes, and their subsequent use in live-cell studies. Our probes will shed light on the role of ROS in cellular signal transduction or in pathologies such as neurodegenerative diseases. Nanomaterials-Nanoprobes The fabrication of nanocomposite materials for biophotonic applications; novel biomaterials with unique optical properties intended for protein-lipid membrane interaction studies and for developing novel high throughput sensing platforms. Single Molecule Spectroscopy The utilization and development of state-of-art nanotools, specifically single molecule fluorescence techniques, to unravel complex mechanistic interactions and understand inhibitor mechanisms on polymerase activities. We seek to provide a “molecular movie” with nanometer spatial resolution and microsecond time resolution, enabling, the characterization of an enzyme dynamic behavior at the single molecule level.

近期论文

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Glembockyte, V.; Lincoln, R.; Cosa, G.; Cy3 Photoprotection Mediated by Ni2+ for Extended Single-Molecule Imaging: Old Tricks for New Techniques. J. Am. Chem. Soc. 137, 2015, 1116–1122. Godin, R.; Liu, H.-W.; Smith, L.; Cosa, G.; Dye Lipophilicity and Retention in Lipid Membranes: Implications for Single Molecule Spectroscopy. Langmuir, 30, 2014, 11138–11146 Karam, P.; Hariri, A.A.; Calver, C.F.; Zhao, X,; Schanze, K.S.; Cosa, G.; Interaction of Anionic Phenylene Ethynylene Polymers with lipids: from membrane embedding to liposome fusion. Langmuir, 30, 2014, 10704-10711. Lincoln, R.; Greene, L.; Krumova, K..; Ding, Z.; Cosa, G.; Electronic Excited State Redox Properties for BODIPY Dyes Predicted from Hammett Constants: Estimating the Driving Force of Photoinduced Electron Transfer, J. Phys. Chem. A, 118, 2014, 10622-10630