个人简介

PhD - Comparative Endocrinology University of Aston, 1983 BSc University of Aston, 1979 2012 - Faculty of Science Award of Excellence in Community Outreach, University of Calgary. 2005 - 18th Khwarazmi International Distinguished Research Award, Research Organization for Science and Technology. 2002 - Research Achievement Recognition-Celebration of Excellence, University of Calgary. 2001 - Grace Pickford Medal, International Federation of Endocrinological Societies. 2000 - Professorship/Lectureship in Science and Sustainable Development, UNESCO and International Council of Science / the Third World Academy of Sciences.

研究领域

Integrative Cell Biology

Research in my laboratory is centered on the endocrine control of reproduction and growth. Emphasis is placed on two levels of regulatory systems: i) Control of pituitary gonadotropin and growth hormone gene expression by hypothalamic gonadotropin-releasing hormone (GnRH) and gonadal steroids, and ii) paracrine regulation of ovarian function by GnRH and growth factors. My research provided novel information on GnRH functional diversity in a number of cell types of fish and mammalian origin and developed technologies relevant to pharmaceutical and agri-food industries. These include development of: 1) novel GnRH agonists with improved ovulatory and antitumor properties, and 2) method for enhancing growth rate in cultured fish species, using transgenic canola seeds expressing fish growth hormone. To date, there have been a number of opportunities for translation of this basic research into technologies relevant to pharmaceutical and agri-food industries. These technologies include 1) identification of novel tumor-specific GnRH analogs, and 2) large-scale production of recombinant carp growth hormone and development of a food supplement for improving growth rate in cultured fish. In addition, we are involved in a collaborative effort to develop a valid method of measuring environmental compounds with steroid-like activity. It is anticipated that these studies will provide fundamental information on hormonal control of growth and reproduction as well as developing technologies related to environment, aquaculture and medicine.

近期论文

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Kinch CD , Ibhazehiebo K, Jeong JH, Habibi HR, KurraschDM (2015) Low Dose Exposure to Bisphenol A and Replacement Bisphenol S Induces Precocious Hypothalamic Neurogenesis in Embryonic Zebrafish, PNAS, in press. Moussavi M, Wlasichuk M, Chang J.P, and Habibi H.R. (2014) Gonadotropin-Inhibitory hormone (GnIH), Gonadotrophin releasing hormone, Growth hormone, Pitutitary, goldfish. J. Endocrinology, in press. Golshan M, Hatef A, Zare A, Socha M, Milla S, Gosiewski G, Fontaine P, Sokołowska-Mikołajczyk M, Habibi HR, Alavi H (2014) Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo. Aquatic Toxicology, 155C:73-83. doi: 10.1016/j.aquatox.2014.06.004 Hontela A and Habibi HR (2014) Personal care products in the aquatic environment: a case study on the effects of Triclosan in fish. Fish Physiology, 33: Organic Chem. Tox. Fishes, ISBN: 978-0-12-398254-4, (Tierney K, Farrell T, Brauner C, eds), 411-437 pp. Habibi HR (2014) Environmental contaminants with hormone-like activity: Screening and risk characterization. Canadian Civil Engineer, 31.2: 20-23. Annett R, Habibi HR, Hontela A (2014) Impact of glyphosate and glyphosate-based herbicides on the freshwater environment. Journal of Applied Toxicology, J Applied Toxicol. 34(5):458-479. Shin HS, Habibi HR, Choi CY (2014) The environmental regulation of maturation in goldfish, Carassius auratus: Effects of various LED light spectra. Comp Biochem Physiol A Mol Integr Physiol. 168:17-24. Shin HS, Kim NN, Choi YJ, Habibi HR, Kim JW, Choi CY (2013) Light-emitting diode spectral sensitivity relationship with reproductive parameters and ovarian maturation in yellowtail damselfish, Chrysiptera parasema. J Photochem Photobiol B. 127:108-13. Nelson ER and Habibi (2013) Estrogen receptor function and regulation in fish and other vertebrates. General and Comparative Endocrinology, 192:15-24. Kim NN, Lee J, Habibi HR, Choi CY (2013) Molecular cloning and expression of caspase-3 in the protandrous cinnamon clownfish during sex change. Fish Physiol Biochem, 39(3):417-29. Moussavi M, Wlasichuk M, Chang J.P, and Habibi H.R. (2013) Seasonal effect of GnIH on GnRH-induced gonadotroph functions in the goldfish pituitary. J. Neuroendocrinol 25(5):506-516 Evans JS, Jackson LJ, Habibi HR, Ikonomou MG (2012) Feminization of longnose dace (Rhinichthys cataractae) in the Oldman River, Alberta (Canada) provides evidence of widespread endocrine disruption in an agricultural basin. Scientifica, Volume 2012, Article ID 521931, 11 pages http://dx.doi.org/10.6064/2012/521931 Hatef A, Zare A, Hadi Alavi, SM, Habibi HR, Linhart O (2012) Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to Bisphenol A. Environmental Toxicology and Chemistry 31(9):2069-2077. Allan ERO and Habibi HR (2012) Direct effects of triiodothyronine on production of anterior pituitary hormones and gonadal steroids in goldfish. Mol Reprod & Development 79(9):592-602. Kim NN, Habibi HR, Lee J, Choi CY (2012) Effects of recombinant gonadotropin hormones on the expression of vitellogenin, gonadotropin subunits and gonadotropin receptors in cinnamon clownfish, Amphiprion melanopus. Comp Biochem Physiol B 162(4):73-80 Jordan J, Zare A, Jackson LJ, Habibi HR, Weljie AM (2012) Exposure to low concentrations of waterborne contaminants, individually and in a mixture, causes disruption in metabolism in fish. Journal of Proteome Research 11(2):1133-1143. Moussavi M, Wlasichuk M, Chang JP, and Habibi HR (2012) Seasonal effect of GnIH on gonadotrope functions in the pituitary of goldfish, Mol. & Cellular Endocrinology 350(1):53-60. Nelson ER, Allan ER, Pang FY, Habibi HR (2011) Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis. Gen Comp Endocrinol 172:50-56 Jeffries KM, Jackson LJ, Ikonomou MG, Habibi HR (2010) Presence of natural and anthropogenic organic contaminants and potential fish health impacts along two river gradients in Alberta, Canada. Environmental Toxicology & Chemistry 29(10):2379-8. Nelson ER, Allan ERO, Pang F and Habibi HR (2010) Thyroid Hormone and Reproduction: Regulation of Estrogen Receptors in Goldfish Gonads, Molecular Reproduction and Development, 77(9):784-94.