Chang, John Philip - University of Calgary - Department of Biological Sciences

个人简介

PhD - Zoology University of Alberta, 1983 MSc - Zoology University of Manitoba, 1979 BSc University of Manitoba, 1975

研究领域

Signal transduction mechanisms integrating the neuroendocrine regulation of vertebrate pituitary hormone release, especially in fishes. Neuroendocrine regulation of reproduction and growth. Evolution of receptors and post-receptor mechanisms of hypothalamic neuropeptides and bioamines, particularly GnRH peptides, PACAP, somatostatins, Ghrelin, serotonin, dopamine and norepinephrine.

近期论文

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Canosa, L.F., Chang, J.P., Peter, R.E. 2007. Neuroendocrine control of growth hormone in fish. General and Comparative Endocrinology. 151: 1-26. Martyniuk, C.J., Chang, J.P., and Trudeau, V.L. 2007. The effects of GABA agonists on GAD, GABA-T, activin, sGnRH, and tyrosine hydroxylase mRNA in the goldfish (Carassius auratus) neuroendocrine brain. J Neuroendocrinology. 19: 390-397. Hontela, A., Leblond, V.S., Chang, J.P. 2008. Purification and isolation of corticosteroidogenic cells from head kidney of rainbow trout (Oncorhynchus mykiss) for testing cell-specific effects of a pesticide. Comparative Biochemistry and Physiology – Part C: Toxicology & Pharmacology. 147: 52-60. Mitchell, G., Sawisky, G.R., Grey, C.L., Wong, C.J, Uretsky, A.D., Chang, J.P. 2008. Differential involvement of nitric oxide signaling in dopamine and PACAP stimulation of growth hormone release in goldfish. Gen. Comp. Endocrinol. 155: 318-327. Klausen, C., Booth, M., Habibi, H.R., Chang, J.P. 2008. Extracellular signal-regulated kinase mediates gonadotropin subunit gene expression and LH release responses to endogenous gonadotropin-releasing hormones in goldfish. Gen. Comp. Endocrinol. 158: 36-46. Yu, Y., Wong, A.O.L., and Chang, J.P. 2008. Serotonin interferes with Ca2+ and PKC signaling to reduce gonadotropin-releasing hormone-stimulated GH secretion in goldfish pituitary cells. General and Comparative Endocrinology 159: 58-66. Grey, C.L., and Chang, J.P. 2009. Ghrelin-induced growth hormone release from goldfish pituitary cells involves voltage-gated calcium channels. Gen. Comp. Endocrinol. 160: 148-157. Chang, J.P., Johnson, J.D., Sawisky, G.R., Grey, C.L., Mitchell, G., Booth, M., Volk, M.M., Parks, S.K., Thompson, E., Goss, G.G., Klausen, C., and Habibi, H.R. 2009. Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts – studies on the goldfish model. Gen. Comp. Endocrinol. 161: 42-52. Zhao, E., Basak, A., Wong A.O.L., Ko, W., Chen, A., López, G.C., Grey, C.L., Canosa, L.F., Somoza, G.M., Chang, J.P., Trudeau, V.L. 2009. The secretogranin II-derived peptide secretoneurin stimulates luteinizing hormone secretion from gonadotrophs. Endocrinology (accepted Dec 10, 2008; doi:10.1210/en.2008-1060). Cao, Y.B., Chen, X.Q., Wang, S., Chen, X.Z., Wang, Y.X., Chang, J.P., Du, J-Z. 2009. Growth hormone and insulin-like growth factor of naked carp (Gymnocypris przewalskii) in Lake Qinghai: expression in different water environments. General and Comparative Endocrinology (accepted Feb 9, 2009; doi: 10.1016/j.ygcen.2009.02.005)