Barrette-Ng, Isabelle - University of Calgary - Department of Biological Sciences

个人简介

PhDUniversity of Alberta, 2003 MScUniversité de Montréal, 2001 BSc (Hons)Queen's University, 1998

研究领域

As an instructor in the Department of Biological Sciences, I am particularly interested in the design and implementation of novel, inquiry-based and blended learning exercises and laboratories. I am also very interested in the design and implementation of computer-based tutorials to help in the teaching of difficult concepts in genetics and biochemistry. My main research interests revolve around the use of X-ray crystallography and bioinformatics to study the structure and function of proteins and RNA. I am particularly interested in the design of small molecule ligands for a wide variety of proteins.

近期论文

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Barrette-Ng, I.H., Ng, K.K., Cherney, M.M., Pearce, G., Ghani, U., Ryan, C.A., James, M.N. (2003) Unbound form of tomato inhibitor-II reveals interdomain flexibility and conformational variability in the reactive site loops, Journal of Biological Chemistry, 278(33), 31391-400 Barrette-Ng, I.H., Ng, K.K., Cherney, M.M., Pearce, G., Ryan, C.A., James, M.N. (2003) Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor and subtilisin Carlsberg, Journal of Biological Chemistry, 278(26), 24062-71 Barrette-Ng, I.H., Ng, K.K., Mark, B.L., Van Aken, D., Cherney, M.M., Garen, C., Kolodenko, Y., Gorbalenya, A.E., Snijder, E.J., James, M.N. (2002) Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta terminal extension and alternate conformations of the oxyanion hole, Journal of Biological Chemistry, 277(42), 39960-6 Dargis, R., Pearlstone, J.R., Barrette-Ng, I.H., Edwards, H., Smillie, L.B. (2002) Single mutation (A162H) in human cardiac troponin I corrects acid pH sensitivity of Ca2+-regulated actomyosin S1 ATPase, Journal of Biological Chemistry, 277(38), 34662-5 Barrette, I., Poisson, G., Gendron, P., Major, F. (2001) Pseudoknots in prion protein mRNAs confirmed by comparative sequence analysis and pattern searching, Nucleic Acids Research, 29(3), 753-8 Barrette, I.H., McKenna, S., Taylor, D.R., Forsdyke, D.R. (2001) Introns resolve the conflict between base order-dependent stem-loop potential and the encoding of RNA or protein: further evidence from overlapping genes, Gene, 270(1-2): 181-9 Cristillo, A.D., Mortimer, J.R., Barrette, I.H., Lillicrap, T.P., Forsdyke, D.R. (2001) Double-stranded RNA as a not-self alarm signal: to evade, most viruses purine-load their RNAs, but some (HTLV-1, Epstein-Barr) pyrimidine-load, Journal of Theoretical Biology, 208(4), 475-91