个人简介

B.Sc. Chemistry (Université du Québec à Chicoutimi) Ph.D. Organic Chemistry (University of Alberta, Prof. John C. Vederas) PDF Pharmaceutical Chemistry (University of California, San Francisco, Prof. Paul R. Ortiz de Montellano) Assistant Professor of Chemistry, McGill University 2002-2008 Associate Professor of Chemistry, McGill University since 2009 Associate Member of Biochemistry, McGill University since 2002

研究领域

Chemical Biology Synthesis/Catalysis

Our research takes advantage of chemical tools to study and manipulate biological systems. We are especially interested in antibiotic resistance, P450 enzymes and biocatalysis (towards green chemistry). The methods used range from medicinal chemistry and organic synthesis, to enzymology, molecular biology, biophysical studies, and more

近期论文

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Freiburger, L., Miletti, T., Zhu, S., Baettig, O., Berghuis, A. M., Auclair, K., Mittermaier, A.K. Substrate-dependent switching of the allosteric binding mechanism of aminoglycoside (6') acetyltransferase-Ii. Nature Chem. Biol., doi: 10.1038/nchembio.1626. Polic, V., Auclair, K. Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis. Bioorg. Med. Chem. 2014, doi: 10.1016/j.bmc.2014.06.034. Hoegl, A., Darabi, H., Tran, E., Awuah, E., Kerdo, E., Saliba, K. J., Auclair, K. Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity. Bioorg. Med. Chem. Lett. 2014, 24, 3274-3277. Awuah, E., Ma, E., Hoegl, A., Vong, K., Habib, E., Auclair, K. Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase. Bioorg. Med. Chem. 2014, 22, 3083-3090. Menard, A., Fabra, C., Huang, Y., Auclair, K. Type II ligands as chemical auxiliaries to favor enzymatic transformations by P450 2E1. ChemBioChem, 2012, 13, 2527-2536. Larsen, A. T., Lai, T., Polic, V., Auclair, K. Dual use of a chemical auxiliary: molecularly imprinted polymers for the selective recovery of products from biocatalytic reaction mixtures. Green Chem. 2012, 14, 2206-2211. Menard, A., Huang, Y., Karam, P., Cosa, G., Auclair, K. Site-Specific Fluorescent Labeling and Oriented Immobilization of a Triple Mutant of CYP3A4 via C64. Bioconjug. Chem. 2012, 23, 826-836. Vong, K., Tam, I. S., Yan, X., Auclair, K. Inhibitors of aminoglycoside resistance activated in cells. ACS Chem. Biol. 2012, 7, 470-475. Vong, K., Auclair, K. Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. Med. Chem. Commun. 2012, 3, 397-407. Tewari, B. B., Beaulieu-Houle, G., Larsen, A., Auclair, K., Butler, I. S. An overview of molecular spectroscopic studies on theobromine and related alkaloids. Appl. Spectrosc. Rev. 2012, 47, 163-179. Freiburger, L. A., Auclair, K., Mittermaier, A. K. Van't Hoff global analyses of variable temperature isothermal titration calorimetry data. Thermochimica Acta 2012, 527, 148-157. Szychowski, J., Kondo, J., Zahr, O., Auclair, K., Westhof, E., Hanessian, S., Keillor, J. W. Inhibition of aminoglycosides-deactivating enzymes APH(3')-IIIa Larsen, A. T., May, E. M., Auclair, K. Predictable stereo- and chemo-selective hydroxylations with P450 3A4. J. Am. Chem. Soc. 2011, 133, 7853-7858. Akinnusi, T. O., Vong, K., Auclair, K. Geminal dialkyl derivatives of N-substituted pantothenamides: Synthesis and antibacterial activity. Bioorg. Med. Chem. 2011, 19, 2696-2706. Freiburger, L. A., Baettig, O. M., Berghuis, A. M., Auclair, K., Mittermaier, A. K. Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme, Nat. Struct. Mol. Biol. 2011, 18, 288-294. Freiburger, L. A., Mittermaier, A. K., Auclair, K. Collecting variable-concentration isothermal titration calorimetry datasets in order to determine binding mechanisms. J. Vis. Exp. doi: 10.3791/2529 (http://www.jove.com/details.stp?id=2529). Yan, X., Akinnusi, O., Larsen, A. T., Auclair, K. Synthesis of 4'-aminopantetheine and derivatization for bacterial studies. Org. Biomol. Chem. 2011,9, 1538-1546. Freiburger, L. A., Auclair, K., Mittermaier, A. K. Elucidating Protein-Binding Mechanisms by Variable-c ITC. ChemBioChem, 2009, 10, 2871-2873. Gao, F., Yan, X., Vong, K., Auclair, K. Synthesis of a phosphonate-linked aminoglycoside-CoA bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance. Chem. Eur. J. 2009, 15, 2064-2070 Zhao, J., Auclair, K. The activity of human CYP2D6 in low water organic solvents. Biotech. Bioeng. 2009, 102, 1268-1272. Gao, F., Yan, X., Zahr, O., Larsen, A., Vong, K., Auclair, K. Use of Sulfonamide-, Sulfoxide-, or Sulfone-containing Aminoglycoside-CoA Bisubstrates as Mechanistic Probes for Aminoglycoside N-6 -Acetyltransferase. Bioorg. Med. Chem. Lett. 2008, 18, 5518-5522. . Kotakadi V, Jin Y, Hofseth AB, Ying L, Cui X, Volate S, Chumanevich A, Wood P, Price R, McNeal A, Singh UP, Singh N, Nagarkatti M, Nagarkatti P, Matesic LE, Auclair K, Wargovich MJ, Hofseth LJ. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.Carcinogenesis 2008, 29, 1799-1806. Magalhães, M. L. B., Vetting,M. W., Gao, F., Freiburger, L., Auclair, K., Blanchard, J. S. Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica. Biochemistry 2008, 47, 579-584.