个人简介

B.S., Pennsylvania State University, 1983; Ph.D., Caltech, 1987. Senior Research Fellow, Caltech, 1991-92; Assistant Professor, 1992-98; Associate Professor, 1998-2003; Professor, 2003-07; Bren Professor, 2007-; HHMI Investigator, 1994-07; Executive Officer for Biochemistry and Molecular Biophysics, 2004-07; Vice Provost, 2007-10; Division Chair, 2010-; Bowes Jr. Leadership Chair, 2012-.

研究领域

Mayo's focus has been the coupling of theoretical, computational, and experimental approaches for the study of structural biology. In particular, he has placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy.

Biochemistry, Structural, and Molecular Cell Biology; Biological Engineering

近期论文

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A. Marshall, C. L. Vizcarra, and S. L. Mayo, "One and Two Body Decomposable Poisson-Boltzmann Methods for Protein Design Calculations," Protein Science, 14, 1293-1304, 2005. M. Shifman and S. L. Mayo, "Exploring the Origins of Binding Specificity Through the Computational Redesign of Calmodulin," PNAS USA, 100, 13274-13279, 2003. N. Bolon and S. L. Mayo, "Enzyme-like Proteins by Computational Design," PNAS USA, 98, 14274-14279, 2001. A. Voigt, S. L. Mayo, F. H. Arnold, Z. Wang, "Computational Method to Reduce the Search Space for Directed Protein Evolution," PNAS, 98, 3778-3783, 2001. A. Marshall and S. L. Mayo, "Achieving Stability and Conformational Specificity in Designed Proteins Via Binary Patterning," J. Mol. Bio., 305, 619-631, 2001. Shimaoka, J. M. Shifman, H. Jing, J. Takagi, S. L. Mayo, and T. A. Springer, "Computational Design of an Integrin I Domain Stabilized in the Open High Affinity Conformation," Nature Structural Biology, 7, 674-678, 2000. A. Pierce, J. A. Spriet, J. Desmet and S. L. Mayo, "Conformational Splitting: a More Powerful Criterion for Dead-End Elimination," J. Comp. Chem., 21, 999-1009, 2000. M. Malakauskas and S. L. Mayo, "Design, Structure and Stability of a Hyperthermophillic Protein Variant," Nature Struc. Bio., 5, 470-475, 1998. I. Dahiyat and S. L. Mayo, "De Novo Protein Design: Fully Automated Sequence Selection," Science, 278, 82-87, 1997.