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个人简介

B.A. (Carleton College, 1988) Ph.D. (Stanford University, 1993) Postdoctoral Fellow (U. California, Berkeley, 1993-1995) James McGill Professor (McGill Canadian Research Chair Equivalent, Tier I)

研究领域

Synthesis/Catalysis

Our research interests lie in the development of new and efficient methods to synthesize organic molecules and new materials via transition metal catalysis. This is often directed towards compounds of biological importance or potential new drug cores. We are also exploring the application of metal catalysis to the synthesis of new classes of polymers. In developing these reactions, we rely upon mechanistic insights into transition metal based transformations, and their extension to new and practical synthetic methods.

近期论文

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Chiral Phosphorus-Based 1,3-Dipoles: A Modular Approach to Enantioselective 1,3-Dipolar Cycloaddition and Polycyclic 2-Pyrroline Synthesis Morin, M. S. T.; Arndtsen, B. A. Org. Lett. 2014, 16, 1056. Palladium-Catalyzed Stille-Type Coupling of N-Acyl Iminium Ions with Distannanes: A Multicomponent Synthesis of α-Amidostannanes Xu, B.; Arndtsen, B. A. ACS Catal. 2014, 4, 843. Oxidative Addition of Haloalkanes to Metal Centers: A Mechanistic Investigation Yempally, V.; Moncho S.; Muhammad S.; Brothers E.N.; Arndtsen, B. A.; Bengali A. A. Organometallics 2014, 33, 3591. A Palladium-Catalyzed Carbonylation Approach to Acid Chloride Synthesis Quesnel, J. S.; Arndtsen, B. A. J. Am. Chem. Soc. 2013, 135, 16841. Transition-Metal-Catalyzed Multicomponent Coupling Reactions with Imines and Carbon Monoxide Ve, J. S.; Arndtsen, B. A. Pure Appl. Chem. 2013, 85, 377. Modular Mesoionics: Understanding and Controlling Regioselectivity in 1,3-Dipolar Cycloadditions of Münchnone Derivatives Morin, M. S. T.; St-Cyr, D. J.; Arndtsen, B. A.; Krenske, E. H.; Houk, K. N. J. Am. Chem. Soc. 2013, 135, 17349. Phosphonite Mediated 1,3-Dipolar Cycloaddition: a Route to Polycyclic 2-Pyrrolines from Imines, Acid Chlorides and Alkenes Morin, M. S. T.; Aly, S.; Arndtsen, B. A. Chem. Commun. 2013, 49, 883. Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides Xu, B.; Worrall, K.; Arndtsen, B. A. Molecules 2012, 17, 13759. Copper-Catalyzed Petasis-Type Reaction: A General Route to α-Substituted Amides From Imines, Acid Chlorides, and Organoboron Reagents Morin, M. S. T.; Lu, Y.; Black, D. A.; Arndtsen, B. A. J. Org. Chem. 2012, 77, 2013. A Palladium-Patalyzed Multicomponent Synthesis of Imidazolinium Salts and Imidazolines from Imines, Acid Chlorides, and Carbon Monoxide Worrall, K.; Xu, B.; Bontemps, S.; Arndtsen, B. A. J. Org. Chem. 2011, 76, 170. Synthesis of Neutral Nickel-Methyl Complexes with Monodentate Imines and their Sequential Insertion of Carbon Monoxide and Imine Stafford, C.; Arndtsen, B. A. Inorg. Chim. Acta 2011, 369, 231. A Palladium-Catalyzed Multicomponent Coupling Approach to π-Conjugated Oligomers: Assembling Imidazole-Based Materials from Imines and Acyl Chlorides Siamaki, A. R.; Sakalauskas, M.; Arndtsen, B. A. Angew. Chem., Int. Ed. 2011, 50, 6552. Comparison of Imine to Olefin Insertion Reactions: Generation of Five- and Six-Membered Lactams via a Nickel-Mediated CO, Olefin, CO, Imine Insertion Cascade Davis, J. L.; Arndtsen, B. A. Organometallics 2011, 30, 1896. Palladium-Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five-Component Coupling Reaction Bontemps, S.; Quesnel, J. S.; Worrall, K.; Arndtsen, B. A. Angew. Chem., Int. Ed. 2011, 50, 8948.

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