个人简介
Postdoctoral Associate M.I.T., 2014-2015, Advisor: Stephen L. Buchwald
Ph.D. University of Minnesota - Twin Cities, 2013, Advisor: Thomas R. Hoye
M.S. University of Minnesota - Twin Cities, 2010, Advisor: Thomas R. Hoye
B.E. Southeast University 2006
Awards and Honors
2014 Reaxys PhD Prize Winner
2017 Thieme Chemistry Journal Award
研究领域
1. Site-selective modification of glycosides
Rapid accesses to analogues and derivatives of glycosides offer tremendous opportunities to explore and exploit the properties of these compounds. However, many glycosides contain many hydroxyls that are similar in reactivities. It remains a significant challenge to differentiate these hydroxyls by chemical methods. Our group is interested in the development of methods to selectively modify certain hydroxyls of these complex molecules. Some of the examples can be seen in our recent paper published in ACIE, Chem, and summarized in Carbohydr. Res. More results in this field are coming soon.
2. Synthesis of C-glycosides
C-glycosides are often explores as analogues of O-glycosides, but are more stable toward enzymatic hydrolysis than the latter. Our group is interested in the development of general and user-friendly methods to prepare this class of carbohydrate derivatives. Some of the examples can be seen in our recent paper published in JACS. More results in this field are coming soon.
3. Synthesis of complex glycoconjugates
Some glycoconjugates are structurally very complex. Methods that are highly functional group tolerant prove effective to synthesize this products but remain rare. Our group is also interested in the development of such methods that are ultimately used in the construction of complex glycoconjugates. Some of the early results are published in ACIE.
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation Chen Zhang, Hao Zuo, Ga Young Lee, Yike Zou, Qiu-Di Dang, K. N. Houk* and Dawen Niu* Nature Chemistry 2022
Nonenzymatic Stereoselective S-Glycosylation of Polypeptides and Proteins Li-Qiang Wan, Xia Zhang, Yike Zou, Rong Shi, Jin-Ge Cao, Shi-Yang Xu, Li-Fan Deng, Li Zhou, Yanqiu Gong, Xiaoling Shu, Ga Young Lee, Haiyan Ren, Lunzhi Dai, Shiqian Qi, K. N. Houk, and Dawen Niu* J. Am. Chem. Soc. 2021, ASAP
Stereoselective Preparation of C-Aryl Glycosides via Visible-Light-Induced Nickel-Catalyzed Reductive Cross-Coupling of Glycosyl Chlorides and Aryl Bromides Ze-Dong Mou, Jia-Xi Wang, Xia Zhang,* and Dawen Niu* Adv. Synth. Catal. 2021, 363, 3025– 3029 (Very Important Publication)
Site-switchable mono-O-allylation of polyols (Selective modification of polyols, carbohydrates, and natural products) Hua Tang, Yu-Biao Tian, Hongyan Cui, Ren-Zhe Li, Xia Zhang, Dawen Niu* Nature Communications volume 11, Article number: 5681 (2020)
A radical approach to make unnatural amino acids through converting C–S bonds in cysteine derivatives to C–C bonds （Functional group tolerant method of making peptide derivatives） Yingwei Wang, Li-Fan Deng, Xia Zhang*, Ze-Dong Mou, Dawen Niu* Angewandte Chemie International Edition, 2021, 60, 2155–2159
Generation of Glycosyl Radicals from Glycosyl Sulfoxides and Its Use in the Synthesis of C‐linked Glycoconjugates Weidong Shang, Sheng‐Nan Su, Rong Shi, Ze‐Dong Mou, Guo‐Qiang Yu, Xia Zhang*，Dawen Niu* Angewandte Chemie International Edition, 2021, 60, 385–390
Asymmetric O-propargylation of secondary aliphatic alcohols （Asymmetric propargylation of monosaccharides and natural products）Ren-Zhe Li, Da-Qi Liu, Dawen Niu* Nature Catalysis, 2020, 3, 672–680
Catalytic Asymmetric Synthesis of α-Tetrasubstituted α-Trifluoromethyl Homoallylic Amines by Ir-Catalyzed Umpolung Allylation of Imines Yingwei Wang, Li-Fan Deng, Xia Zhang,* and Dawen Niu* Org. Lett. 2019, 21, 17, 6951-6956
Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of α-Oxo-Vinylsulfones to Prepare C-Aryl Glycals and Acyclic Vinyl Ethers Liang Gong, Hongbao Sun, Li-fan Deng, Xia Zhang, Jie Liu, Shengyong Yang, and Dawen Niu* Journal of the American Chemical Society, 2019, 141, 19, 7680-7686
Ligand-controlled, transition-metal catalyzed site-selective modification of glycosides Weidong Shang, Bin He, and Dawen Niu* Carbohydrate Research, 2019, 474, 16-33 (invited review)
2-Azaallyl Anions, 2-Azaallyl Cations, 2-Azaallyl Radicals, and Azomethine Ylides Shaojian Tang†, Xia Zhang†, Jiayue Sun, Dawen Niu*, and Jason J. Chruma* Chem. Rev., 2018, 118(20), 10393–10457
Diastereo‐ and enantioselective propargylations of 5H‐thiazol‐4‐ones and 5H‐oxazol‐4‐ones as enabled by Cu/Zn and Cu/Ti catalysis Zhengyan Fu, Ning Deng, Sheng-Nan Su, Hongyang Li, Ren-Zhe Li, Xia Zhang, Jie Liu, and Dawen Niu* Angewandte Chemie International Edition, 2018, 57(46), 15217-15221
Metal‐ and Base‐Free Room‐Temperature Amination of Organoboronic Acids with N‐Alkyl Hydroxylamines Hong‐Bao Sun, Liang Gong, Yu‐Biao Tian, Jin‐Gui Wu, Xia Zhang, Jie Liu, Zhengyan Fu, and Dawen Niu* Angewandte Chemie International Edition, 2018 57(30), 9456-9460
Site-Selective O-Arylation of Glycosides Weidong Shang, Ze-Dong Mou, Hua Tang, Xia Zhang, Jie Liu, Zhengyan Fu, and Dawen Niu* Angewandte Chemie International Edition, 2018, 130(1), 320-324
Site-Divergent Delivery of Terminal Propargyls to Carbohydrates by Synergistic Catalysis Ren-Zhe Li, Hua Tang, Liqiang Wan, Xia Zhang, Zhengyan Fu, Jie Liu, Shengyong Yang, Da Jia, and Dawen Niu* Chem 2017, 3, 834-845
Iridium-Catalyzed Asymmetric Umpolung Allylation of N-Fluorenyl Imines to Prepare 1,4-Disubstituted Homoallylic Amines Liqiang Wan, Lan Tian, Jie Liu, and Dawen Niu* Synlett 2017, 28(16), 2051-2056 (invited review)
Enantioselective Propargylation of Polyols and Desymmetrization of meso 1,2-Diols by Copper/Borinic Acid Dual Catalysis R-Z Li, H Tang, KR Yang, L-Q Wan, X Zhang, J Liu, Z Fu, and D Niu* Angewandte Chemie International Edition 2017, 56, 7213–7217
Catalytic Asymmetric Umpolung Allylation of Imines J Liu, C-G Cao, H-B Sun, X Zhang, and D Niu* Journal of the American Chemical Society 2016, 138, 13103–13106
Silver-Assisted, Iridium-Catalyzed Allylation of Bis[(pinacolato)boryl]methane Allows the Synthesis of Enantioenriched Homoallylic Organoboronic Esters M Zhan, R-Z Li, Z-D Mou, C-G Cao, J Liu*, Y Chen*, and D Niu* ACS Catal., 2016, 6, 3381–3386
The Hexadehydro-Diels–Alder Cycloisomerization Reaction Proceeds by a Stepwise Mechanism T Wang, D Niu, and TR Hoye* Journal of the American Chemical Society 2016, 138 (25) 7832–7835
京公网安备 11010802027423号